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Misidentified DNA leads authors to retract zebrafish cholesterol paper

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Authors are retracting a 2012 paper on cholesterol metabolism in zebrafish after realizing it included a case of mistaken identity in a DNA sequence crucial to some aspects of the experiment.  

A postdoc misidentified the plasmid in question after failing to fully sequence it before including it in the experiment. A technician in the lab found the mistake, last author Steven Farber, a researcher at the Carnegie Institution for Science in Maryland, explained:

When the omitted region was correctly sequenced we discovered it had an error.

He told us in a phone interview what that felt like:

We were like, holy crap.

Next came months of back and forth with the journal, discussing whether to correct or retract the paper. Farber tells us the mistake, which affects two figures,

was unfortunate. Most of the paper is in fact correct.

The paper, “Visualization of Lipid Metabolism in the Zebrafish Intestine Reveals a Relationship between NPC1L1-Mediated Cholesterol Uptake and Dietary Fatty Acid,” published in Chemistry & Biology, has been cited 21 times, according to Thomson Scientific’s Web of Knowledge.

Here’s the detailed retraction note:  Continue reading Misidentified DNA leads authors to retract zebrafish cholesterol paper

Suspicions of data manipulation lead to correction of testicular cancer paper

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The corresponding author of a paper on testicular cancer is telling readers to discount a figure after she learned it may have been manipulated.

Although that one figure in the 2005 paper in the British Journal of Cancer may be problematic, the authors found data to support the other figures, and its conclusions.

This isn’t the first time first author Kerry Manton has faced questions over her data — in 2012, one of her papers was retracted following an investigation by her institution, the Queensland University of Technology. And in 2014, QUT repaid a $275,000 grant after finding Manton

failed to fulfill (her) responsibilities in relation to the responsible dissemination of research findings and that this, coupled with a failure to correct the errors, constituted research misconduct.

Here’s the corrigendum for “Hypermethylation of the 5′ CpG island of the gene encoding the serine protease Testisin promotes its loss in testicular tumorigenesis:”

Continue reading Suspicions of data manipulation lead to correction of testicular cancer paper

Prostate cancer paper retracted after investigation can’t review original image

1.coverAn article about how a COX-2 inhibitor (celecoxib) inhibits growth of prostate cancer in rats is being retracted after the authors were unable to provide an investigation committee at New York University with the backup they were asking for.

When the paper was published in 2003, first author Bhagavathi Narayanan worked at the Institute for Cancer Prevention in New York (also known as the American Health Foundation). But when the institute went broke the next year — thanks partly to lavish salaries and offices, as the New York Post reported —  the authors claim they could no longer obtain back up for an image in the paper, once it was questioned years later by NYU, where Narayanan is now based.

Here’s the retraction note, published in Clinical Cancer Research:

Continue reading Prostate cancer paper retracted after investigation can’t review original image

Inventors have a dust up over air sampling device

graphic_amt_cover_homepageTo climate scientist Pieter Tans, a “novel” air sampling device in a recent paper looked a little too familiar. Specifically, like a device that he had invented — the AirCore, which he calls a “tape recorder” for air.

The journal editors came up with a unique solution to the disagreement that followed, which the editor in chief called “rather unclear:” The journal ran an editorial in which both Tans and the authors of the paper contend that their device is unique.

The paper in question, “A novel Whole Air Sample Profiler (WASP) for the quantification of volatile organic compounds in the boundary layer,” was published in Atmospheric Measurement Techniques. It has not been cited, according to Thomson Scientific’s Web of Knowledge.

It now bears a note, in bold and red: “Please read the Editorial Note before accessing the paper.” 

Here’s how the editorial laid out the case:

Continue reading Inventors have a dust up over air sampling device

The Big (Retraction) Short: Securitized loans paper may get change of venue

J financeA paper on the securitized loan industry’s pricing practices was pulled from the Journal of Finance, but may be appearing in another journal.

The Journal of Finance issued a notice of withdrawal, for “Who Facilitated Misreporting in Securitized Loans?” by John M. Griffin and Gonzalo Maturana, but does not say why it was taken out.  Griffin’s web site notes that the paper is to be published in the Review of Financial Studies.

Here’s the note, dated Sept. 23: Continue reading The Big (Retraction) Short: Securitized loans paper may get change of venue

A bullshit excuse? My lab notebook “was blown into a manure pit”

CleanA researcher who studies how to turn dairy cattle manure into natural gas falsified and fabricated data in a journal article and failed to declare a commercial conflict of interest, a Washington State University investigation has found.

The study “Evaluation of Co-Digestion at a Commercial Dairy Anaerobic Digester” was published in 2011 in the journal CLEAN: Soil, Air, Water. First author Craig Frear was a Ph.D. student at WSU Pullman when the study was carried out and an assistant professor at the time of the investigation. The editor-in-chief of CLEAN, Prisca Henheik, told us that the retraction is a done deal even though it has not been posted online: Continue reading A bullshit excuse? My lab notebook “was blown into a manure pit”

Nature retracts paper six years after it was flagged for fraud

cover_natureNature retracted a paper on protein structures today, six years after an investigation at the University of Alabama identified several structures that were “more likely than not falsified and/or fabricated” by one of the authors.

The paper came under scrutiny soon after it was published in 2006. A letter published in Nature that same year pointed out “physically implausible features in the structures it described.” That triggered the investigation at the University of Alabama, the result of which was published in 2009, identifying “nine publications related to the same protein structures that should be retracted from various scientific journals.” Everything was pinned on last author H.M. Krishna Murthy, who the investigation determined was “solely responsible for the fraudulent data.”

A 2009 Nature news article on the investigation declared that the “fraud is the largest ever in protein crystallography.”

We’re not sure what took Nature so long to retract the letter, titled “The structure of complement C3b provides insights into complement activation and regulation.” Here’s the note, which explains that not all the authors agreed to the retraction:

Continue reading Nature retracts paper six years after it was flagged for fraud

Retraction published for nutrition researcher Marion Nestle

journal_pubhealthFollowing her request last month, a public health journal has retracted a paper co-authored by prominent nutrition researcher Marion Nestle, after revelations of multiple factual errors and her co-author’s ties to one of the subjects of the article.

The article, an opinion piece, critiqued the supposed relationship between the biggest beverage distributor in Guatemala and the leading Guatemala-based public health organization, to distribute a fortified supplement (Manì+) for undernourished children. The relationship, the piece argued, raised concerns about the conflicts of interest that can occur when a food company pairs with a public health organization. But soon after publication, Nestle learned that she and her co-author Joaquin Barnoya had misrepresented that relationship, and failed to disclose that the public health organization was paying a portion of Barnoya’s salary.

Here’s the full retraction notice, published earlier this month by the Journal of Public Health Policy: Continue reading Retraction published for nutrition researcher Marion Nestle

Stem cell researcher that sued Harvard failed to disclose conflicts on 6 publications

Piero Anversa, a stem cell researcher who we recently learned is leaving Harvard and Brigham & Women’s Hospital after suing them, has added a disclosure statement to six publications.

The four papers and two letters were published in Circulation, and all bear identical corrections:

Piero Anversa, MD, discloses that he is a member of Analogous, LLC.

The author regrets this omission.

Trouble is, we can’t find a company by that name. What we do know:

Continue reading Stem cell researcher that sued Harvard failed to disclose conflicts on 6 publications

Author retracts statements about gay conversion therapy

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Key assertions in a paper on homosexuality have been removed from the Journal of the Islamic Medical Association of North America, in what the notice describes as a “partial retraction.”

The 2006 article “Homosexuality: An Islamic Perspective,” states that conversion therapy can be effective, and that gay people have poorer health. Those statements are among those that lack evidence, according to a note on the paper published in July. The retraction pulls those assertions, among others, and instead argues that a homosexual person should be helped to “accept his or her LGB identity,” and find a welcoming community.

The 2006 article is definitely a perspective — it states the opinion of the sole author, M. Basheer Ahmed, who has a private psychiatry practice in Texas, as to whether homosexuality is a choice. He thinks yes, though the science on the matter is fairly clear that it’s not.

But we still think it’s interesting that a journal chose to take back some of the statements contained in the article. Here’s the abstract from the “partial retraction” note:

Continue reading Author retracts statements about gay conversion therapy