A pharmaceutical company has admitted that one of its former researchers falsified early data on a compound that’s designed to fight cancer, now in human trials.
The data, published as an abstract in August 2015 in the journal Cancer Research, reported a therapeutic benefit of acalabrutinib in a mouse model of pancreatic cancer. The compound, developed by the company Acerta Pharma, has also been the subject of additional trials published in the New England Journal of Medicine and Bloodin 2015. The 2015 NEJM study, which had several authors in common with the Cancer Research abstract, showed the agent had “promising safety and efficacy profiles in patients” with relapsed chronic lymphocytic leukemia.
But an investigation into the data underlying the 2015 abstract shows some were falsified, prompting the journal to retract the abstract.
Ed Tucker, senior vice president of Medical Safety, Quality and Compliance at Acerta Pharma, told us that in August 2016 the company identified an issue with the data in the Cancer Research abstract and started an investigation:
Earlier this year, the University of California, San Francisco and the San Francisco Veterans Administration Medical Center teamed up to write a letter.
Addressed to the editorial office at the American Association of Cancer Research (AACR), the letter, parts of which have been published in a retraction notice, contained information concerning two papers on genetic risk factors for a type of kidney cancer and a type of uterine cancer, respectively, published in different AACR journals over a decade ago by researchers affiliated with the institutions.
The papers had been at the center of research misconduct investigations at both UCSF and the VA and the investigations came to the conclusion that both papers contained:
fabrication or falsification of data that constitutes Research Misconduct.
A 2016 paper exploring the biology of prostate cancer has been retracted due to figure manipulation.
According to the retraction notice, a reader contacted the journal Clinical Cancer Research in late 2016 with concerns that similar bands appeared multiple times in two images. The editors asked the paper’s corresponding author, Shahriar Koochekpour, about the issue and requested the raw data for the figures. But Koochekpour, based in the Departments of Cancer Genetics and Urology at Roswell Park Cancer Institute in Buffalo, New York, at the time of the study, could not locate the raw data.
Since the lab did not have raw data from such a relatively recent paper, the editors reached out to the research integrity officer at Roswell Park Cancer Institute to investigate. Indeed, the research integrity officer contacted confirmed that two figures were problematic, and requested the paper be retracted.
Image duplications and unsupported data continue to plague a network of cancer researchers that includes the former vice chancellor for research at the University of California, Los Angeles, James Economou.
On July 2, the editors at Cancer Research retracteda 2011 paper that Economou published as last author, saying it suffered from image duplication and unsupported figures. This is the second retraction we’re aware of to come out of an investigation by UCLA’s Office of Research Policy and Compliance that has touched this group of scientists.
The former vice chancellor for research at the University of California, Los Angeles, has retracted a 2012 paper after an internal investigation found evidence of image manipulation.
The journal Molecular Cancer Therapeutics received a letter about the problems with the paper from the UCLA Research Integrity Officer, and a retraction request from last author James Economou, also the chief of surgical oncology.
According to the notice, the paper duplicated images from a 2011 paper also by first author Ali Jazirehi, based at UCLA. This is Jazirehi’s second retraction.
When journals learn papers are problematic, how long does it take them to act?
We recently had a chance to find out as part of our continuing coverage of the case of Anil Jaiswal at the University of Maryland, who’s retracted 15 papers (including two new ones we recently identified), and has transitioned out of cancer research. Here’s what happened.
As part of a public records request related to the investigation, we received letters that the University of Maryland sent to 11 journals regarding 26 “compromised” papers co-authored by Jaiswal, four of which had been retracted by the time of the letter. The letters were dated between August and September 2016 (and one in February) — although, in some cases, the journals told us they received the letter later. Since that date, three journals have retracted nine papers and corrected another, waiting between four and six months to take action. One journal published an editorial note of concern within approximately two months after the university letter.
And six journals have not taken any public action.
Pfizer has retracted a paper by a former employee who was fired after the company discovered she had been doctoring data.
The retraction, in Molecular Cancer Research, is the third of five papers Pfizer asked to retract, after an investigation discovered they contained duplicated images. The papers have been discussed on PubPeer, which is also mentioned in the latest retraction notice.
A pathology journal is retracting two papers after an investigation at the last author’s institution in Germany found evidence of scientific misconduct.
The notice for both papers cites an investigation involving Regine Schneider-Stock, who studies cancer biology at the Friedrich Alexander-University Erlangen-Nuremberg (FAU). Meanwhile, another 2005 paper that lists Schneider-Stock as the first author was retracted in October, noting evidence of image manipulation.
The most recent retractions, from the American Journal of Pathology, note that FAU declined to provide the journal with details of its investigation beyond a prepared statement: