Originally published June 17, 2016, the paper was retracted Jan. 15. Led by corresponding author Xavier Altafaj, of the University of Barcelona (UB) and Bellvitge Biomedical Research Institute (IDIBELL), researchers described using an amino acid, D-serine, to treat a child with a rare genetic disorder that affects neurons.
According to the notice, the researchers did use D-serine in lab work used as proof-of-concept; however, when it came time to try it in the patient, as a result of a “communication error:”
When Alexander Harms arrived at the University of Copenhagen in August 2016, as a postdoc planning to study a type of antibiotic resistance in bacteria, he carried with him a warning from another lab who had recruited him:
People said, “If you go there, you have to deal with these weird articles that nobody believes.”
The papers in question had been published in the Proceedings of the National Academy of Sciences in 2011 and Cell in 2013. Led by Kenn Gerdes, Harms’s new lab director, the work laid out a complex chain of events that mapped out how an E. coli bacterium can go into a dormant state, called persistence, that allows it to survive while the rest of its colony is wiped out.
Despite some experts’ skepticism, each paper had been cited hundreds of times. And Harms told us:
I personally did believe in the published work. There had been papers from others that kind of attacked [the Gerdes lab’s theory], but that was not high-quality work.
A medical journal has retracted a 2016 paper over a series of errors, prompting it to lose faith in the paper overall. The authors have objected to the decision, arguing the errors weren’t their fault and could be revised with a correction — rather than retracting what they consider “an important contribution” to an ongoing debate in medicine.
The paper explored the so-called weekend effect—that patients admitted to the emergency department on the weekend are more likely to die than those admitted on a weekday. Whether the weekend effect is real is not clear. Some studies have supported the phenomenon in certain areas of medicine, but others (including the now-retracted paper) have failed to find an effect.
First author Mohammed A. Mohammed, based at the University of Bradford in the UK, told Retraction Watch that the errors were introduced by one of the hospitals that provided them the data:
A highly cited paper has received a major correction as a result of the ongoing battle over attitudes towards gay people, when a prominent — and polarizing — critic showed it could not be replicated.
In December 2017, researchers led by Mark Hatzenbuehler of Columbia University corrected thepaper, originally published in Social Science & Medicine in February 2014, which showed that gay people who live in areas where people were highly prejudiced against them had a significantly shorter life expectancy. The corrigendum came more than a year after a researcher who has testified against same-sex marriage was unable to replicate the original study.
“Structural stigma and all-cause mortality in sexual minority populations,” has been cited 102 times, according to Clarivate Analytics’ Web of Science, and attracted media coverage when it was published, from outlets such as Reuters andU.S. News & World Report.
What Caught Our Attention:Sadly, it’s not uncommon for researchers to mistake the identity of what they’re working with — but not everyone comes clean and works to transparently correct the record. So it’s nice to see some authors among a group based in the US and India take the initiative to retract their paper after realizing they had based some of their conclusions on the wrong species of aphid.Continue reading Caught Our Notice: Oops, wrong species
What Caught Our Attention: Potassium-rich diets are thought to be “heart-healthy,” and after examining the average dietary habits of Ghanaian adults, researchers determined the average potassium (K) intake to be well below global standards. However, the authors’ calculations of potassium intake per capita were too low by factor of 10, resulting in the incorrect conclusion that the average potassium intake was only 856 mg per day, an amount substantially lower than the World Health Organization (WHO) recommendation of 3510 mg/day. The new calculations show an average K intake of 8,560 mg/day, well over the WHO guideline.
We asked the corresponding author, David Oscar Yawson, about the source of the error, and he responded:
A Nobel Laureate has retracted a 2016 paper in Nature Chemistry that explored the origins of life on earth, after discovering the main conclusions were not correct.
Some researchers who study the origins of life on Earth have hypothesized that RNA evolved before DNA or proteins. If true, RNA would have needed a way to replicate without enzymes. The Nature Chemistry paper found that a certain type of peptide — which may have existed in our early history — made it possible for RNA to copy itself.
But in subsequent experiments, Tivoli Olsen — a member of Szostak’s lab — could not reproduce the 2016 findings. When she reviewed the experiments from the Nature Chemistry paper, she found that the team had misinterpreted the initial data: The peptide in question did not appear to provide an environment that fostered RNA replication.