Category: molecular biology

Florida investigation can’t ID culprit who falsified data in retracted PNAS paper

When the Proceedings of the National Academy of Sciences retracted a gene therapy paper in December, it declared that some of the data had been falsified and mentioned a research misconduct investigation. But the notice said nothing about who was responsible.

Via a public records request, Retraction Watch has obtained investigation documents from the University of Florida, which show the focus had been narrowed down to two of the paper’s three co-first authors. But the investigation committee didn’t assign blame to either one. According to their final report, dated Oct. 24, 2016:

there was not enough direct evidence to either implicate or exonerate either of these individuals.

Over the course of the formal investigation, which lasted from early August to late October 2016,  the committee was able to determine that data in the PNAS paper had been falsified. However, it said: Continue reading Florida investigation can’t ID culprit who falsified data in retracted PNAS paper

Journal retracts note of concern after court settles authorship dispute

A journal has retracted a warning posted to a paper involved in an authorship dispute, after the issue was resolved in a court case.

In an editorial published Jan. 10, editors at the journal Molecules wrote that they were removing the expression of concern for “Helleborus purpurascens—Amino Acid and Peptide Analysis Linked to the Chemical and Antiproliferative Properties of the Extracted Compounds.”

The editors flagged the 2015 paper in June, 2016 after a researcher in Germany also claimed authorship. In the 2016 notice, the editors wrote:

Continue reading Journal retracts note of concern after court settles authorship dispute

Researcher at Japan stem cell institute falsified nearly all images in 2017 paper

Shinya Yamanaka

An investigation by Kyoto University in Japan has found a researcher guilty of falsifying all but one of the figures in a 2017 stem cell paper.

Yesterday, Kyoto University announced that the paper’s first author, Kohei Yamamizu, had fabricated and falsified data in the Stem Cell Reports paper. According to the investigation report, none of the other authors were involved in the data manipulation.

Yamamizu works at the Center for iPS cell Research and Application (CiRA) at Kyoto University, directed by Shinya Yamanaka, a Nobel Prize winner for his pioneering work in stem cell biology.

A spokesperson for the journal told us that the authors disclosed the problems last week and Stem Cell Reports will be retracting the paper, published last February.

In the university’s official statement, Yamanaka said: Continue reading Researcher at Japan stem cell institute falsified nearly all images in 2017 paper

More duplications for researcher accused of misconduct in lawsuit

Despite losing a lawsuit against his former mentor, a researcher hasn’t stopped his efforts to discredit his mentor’s work. These efforts have led to new editorial notices — including, most recently, a correction and expression of concern for one paper by a former colleague, who wasn’t even the subject of the lawsuit.

In the 2014 suit, former Brown University postdoc Andrew Mallon said research misconduct by John Marshall — his lab director and former business partner– tainted a 2013 paper published in PLoS Biology. Though the case failed to trigger the retraction Mallon sought, it put his concerns into the public record; the text of the lawsuit includes an accusation of misconduct against Cong Cao — Marshall’s former mentee and the first author of that 2013 paper.

Mallon has since contacted journals to raise concerns about papers by Cao, and two journals have taken action. The most recent move: On Aug. 10, the Biochemical Journal did something we don’t see very often — it issued both a correction and an expression of concern (EoC) for one of Cao’s papers: “EGFR-mediated expression of aquaporin-3 is involved in human skin fibroblast migration,” originally published Nov. 14, 2006. Continue reading More duplications for researcher accused of misconduct in lawsuit

Unnamed institution makes baffling retraction requests, journals comply

Two journals are retracting papers published by researchers affiliated with Children’s Hospital Los Angeles (CHLA).

To be frank, we’re baffled by most of this story. The retraction notices say “the institution” requested the retractions, but don’t name it; the first and last authors are also affiliated with the University of Southern California, as well as CHLA. Neither journal will say which institution sent the request, and USC and CHLA have each declined to comment on the retractions.

Here’s what we do know: Continue reading Unnamed institution makes baffling retraction requests, journals comply

Author blamed for misconduct in Cell paper declines to sign retraction notice  

Researchers have retracted a 2015 paper in Cell after an investigation revealed the first author committed misconduct.

According to the retraction notice, which first author Ozgur Tataroglu declined to sign, the researchers realized there was an issue with the 2015 paper when they were unable to replicate the findings. Corresponding author Patrick Emery and his team at the University of Massachusetts Medical School in Worcester reviewed the data and found “clear evidence” that Tataroglu  — who had been a postdoc in Emery’s lab — “had repeatedly misrepresented and altered primary data,” the notice states.

UMass subsequently conducted an investigation in which it “concluded that the first author committed scientific misconduct.”  

Here’s the retraction notice for “Calcium and SOL Protease Mediate Temperature Resetting of Circadian Clocks:” Continue reading Author blamed for misconduct in Cell paper declines to sign retraction notice  

Stem cell scientist appealing dismissal loses another paper

Susana Gonzalez

A once-prominent stem cell biologist, who recently lost both her job and a sizable grant, has lost her fifth paper.

Recently, Molecular and Cellular Biology retracted a 2003 paper by Susana Gonzalez. Last February, the National Center for Cardiovascular Research (CNIC) in Spain dismissed her from her position over allegations of misconduct. The reason: suspicions of data manipulation.

As with a previous retraction, the journal said Gonzalez “could not be reached for approval of this retraction.”  

Here’s the full notice:

Continue reading Stem cell scientist appealing dismissal loses another paper

Project to “fact check” genetic studies leads to three more retractions. And it’s just getting started.

Jennifer Byrne

A project to identify studies doomed by problematic reagents has triggered three more retractions, bringing the total to five.

Jennifer Byrne, a scientist at the University of Sydney, who developed the the idea of double-checking the nucleic acid sequences of research materials — thereby ensuring studies were testing the gene in question — told Retraction Watch that all three retractions came after she started emailing journals in January  to alert them to the problems: Continue reading Project to “fact check” genetic studies leads to three more retractions. And it’s just getting started.

Two more retractions for former US prof who altered dozens of images

Two journals have retracted papers by a biologist who was recently found guilty of misconduct by his former employer, the University of Colorado Denver, bringing the total to five.

The investigation report by UC Denver, which we obtained earlier this year via a public records request, had recommended one of the two newest retractions, which appears in the journal Hepatology. The other retraction, in the Journal of Immunology, was not flagged by the report — which found, among other conclusions, that Almut Grenz had altered multiple values in research that had already been submitted for peer review.

Here’s the notice for the Journal of Immunology paper:

Continue reading Two more retractions for former US prof who altered dozens of images

Authors withdraw study, citing “accidentally duplicated” images

Researchers in Australia have withdrawn a 2006 paper in The Journal of Biological Chemistry (JBC), citing image duplication.

In the withdrawal notice, published July 14, 2017, the authors claim that the “errors do not impact the underlying scientific findings of the article.”

Although the notice does not mention an investigation, a comment on PubPeer on March 2017—signed by Mark Hargreaves, the vice-chancellor at the University of Melbourne—indicates that the university conducted an investigation to assess the issues in the paper and determined that research misconduct “did not occur.”

Here’s the withdrawal notice for “Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1:” Continue reading Authors withdraw study, citing “accidentally duplicated” images