Category: investigator error

Does dose matter? Tumor killer paper thought so, now must retract

Molecular Medicine ReportsAfter questions from a reader, researchers took a second look at their data about the effects of a vitamin A metabolite on tumor cells, and realized their key finding was inaccurate.

They’re now retracting the paper, from Molecular Medicine Reports, because it originally reported that higher concentrations of retinoic acid (RA) were more effective in curbing the proliferation of brain tumor cells. But it seems that the RA dose made less of a difference than they originally believed, according to the retraction notice:

Continue reading Does dose matter? Tumor killer paper thought so, now must retract

Nutrition study pulled after statistical flaws emerge

Nutrition JournalA paper that suggested that eating flaxseed could reduce inflammation in men at risk of heart disease has been retracted, after researchers pointed out the paper’s flaws.

The retraction is part of a large initiative on the part of nutrition researcher David Allison and colleagues to clean up the literature, which we’ve previously covered. Regarding this paper, he told us:

When we looked at the study…it was very clear that the statistical methods used were not correct. These are not matters of debate or opinion, these are just…verifiably incorrect.

The Nutrition Journal published the paper in January 2015, and retracted it in June 2016, one day after publishing a letter by Allison and a colleague critiquing the paper. 

Here’s the retraction notice for “Impact of weight loss diet associated with flaxseed on inflammatory markers in men with cardiovascular risk factors: a clinical study:” Continue reading Nutrition study pulled after statistical flaws emerge

Against authors’ wishes, journal pulls study with errors, statistical mistake

Annals of the Rheumatic DiseasesA rheumatology journal has retracted a paper about treating knee pain after an institutional investigation found a mistake in the statistical process.

Over several months, the authors proposed a series of corrections to the 2014 study. However, the journal Annals of the Rheumatic Diseases (ARD) decided that there were “unresolved concerns” about the reliability of the data, and decided to retract the paper entirely, despite the authors’ objections.

Here’s the retraction notice: Continue reading Against authors’ wishes, journal pulls study with errors, statistical mistake

You’ve been dupe’d (again): Do these data look familiar? They are

plant_growth_regulationWe can’t keep up with the growing number of retraction notices, so we’ve compiled a list of recent duplications to update our records.

1. Authors don’t always intentionally duplicate their own work, of course. The first paper on our list was retracted after the authors included a figure from a previous paper by accident, according to the publisher: Continue reading You’ve been dupe’d (again): Do these data look familiar? They are

Vector wasn’t a gift after all, correction notes

CirculationA paper accidentally credited the wrong researcher with providing part of an experiment.

It turns out that one of the authors supplied an expression vector to a Circulation paper about the molecular underpinnings of atherosclerosis — not the outside researcher originally thanked in the acknowledgements section.

The correction notice to the paper makes the situation sound more mysterious than it appears to be:

Continue reading Vector wasn’t a gift after all, correction notes

Diabetes researcher logged 1 retraction, 3 correx, after PubPeer comments

Kathrin Maelder
Kathrin Maedler

A journal has retracted a paper by a leading diabetes researcher — who has also issued three corrections — after questions about her research were raised on PubPeer.

Kathrin Maedler — who works at the University of Bremen in Germany — corrected another paper in 2014. All of the notices are dated from 2015, and all describe issues with figures.

The ongoing comments have led Maedler to carefully look through her original data, according to a statement she emailed us: Continue reading Diabetes researcher logged 1 retraction, 3 correx, after PubPeer comments

“We were completely shocked:” Plant biologists issue mega-correction

Plant Cell cover

Plant biologists have issued a major correction (what we dub “mega“) after realizing a significant mistake in their experiment.

The 2014 paper shows that a protein known as RAP plays a key role in chloroplast biogenesis. But as Ludwig Maximilians University-based authors Alexandra-Viola Bohne and Laura Kleinknecht continued to do their research, they found an error in the design of primers they used to synthesize the RNA for their experiments — and told us they are concerned other researchers could run into the same problem.

Although the authors considered retracting the paper, since its main conclusion was unaffected, they issued a correction notice, published in April in Plant Cell:

Continue reading “We were completely shocked:” Plant biologists issue mega-correction

Genotyping mistake costs lab two papers and year of work

PNASResearchers are retracting two papers about molecular signalling in plants — including one from the Proceedings of the National Academy of Sciences (PNAS) — after discovering some inadvertent genotyping errors. But that was only after they used the problematic plants for an entire year without realizing they’d made a mistake.

In a pair of refreshingly transparent and detailed notices, the authors explain that the transgenic plants used in the papers included genotyping errors, which invalidated their findings. According to the notices, first author Man-Ho Oh generated the problematic transgenic plants, while corresponding author Steven C. Huber, based at University of Illinois, Urbana-Champaign (UIUC), took responsibility for omitting some critical oversight.

Huber told us that there were only two papers that used the transgenic plants in question, so no other retractions will be forthcoming.

Here’s the notice in PNAS for “Autophosphorylation of Tyr-610 in the receptor kinase BAK1 plays a role in brassinosteroid signaling and basal defense gene expression:”  Continue reading Genotyping mistake costs lab two papers and year of work

JAMA authors retract (and replace) paper about moves and kids’ mental health

JAMAJAMA authors have retracted — and replaced — a 2014 paper about the mental health effects of household moves on kids, after they found errors while completing an additional analysis.

The original paper concluded that in “families who moved out of high-poverty neighborhoods, boys experienced an increase and girls a decrease in rates of depression and conduct disorder,” according to a press release issued by the journal along with the paper (which also got some press attention from Reuters). But part of that conclusion is wrong.

The authors write in a notice for “Associations of Housing Mobility Interventions for Children in High-Poverty Neighborhoods With Subsequent Mental Disorders During Adolescence” that:

Continue reading JAMA authors retract (and replace) paper about moves and kids’ mental health

Prompted by PubPeer, biologist corrects three papers

GeneA biologist has corrected three papers that are nearly a decade old, after concerns were raised on PubPeer.

A commenter first posted a comment about an image in one of the papers in 2013; after more comments on other papers appeared in November 2015, author Zoya Avramova at the University of Nebraska-Lincoln received emails alerting her to the threads. She has responded, including to the 2013 comment, noting “the said images should have been assembled more carefully.”

After repeating some of the experiments to verify the results, she has now issued corrections on three papers, about the genetics of model organism Arabidopsis. The papers share a first author, Abdelaty Saleh, who was a postdoc in Avramova’s lab at the time of the work.

The correction notice for “Dynamic and stable histone H3 methylation patterns at the Arabidopsis FLC and AP1 loci,” appearing in the July 2016 volume of Gene, explains:  Continue reading Prompted by PubPeer, biologist corrects three papers