Child took wrong compound for over a year after “communication error”

Credit: Steven Depolo, Flickr

A journal is retracting a paper after it discovered researchers gave a child the wrong supplement for more than a year.

Rhiannon Bugno, managing editor for Biological Psychiatry, told Retraction Watch the mix-up did not put the patient at risk. However, the mistake was enough for the journal’s editor, John Krystal, of Yale University, to request the retraction of a 2016 paper describing the young girl’s experience taking the compound,“Rett-like Severe Encephalopathy Caused by a De Novo GRIN2B Mutation Is Attenuated by D-serine Dietary Supplement.”

Originally published June 17, 2016, the paper was retracted Jan. 15. Led by corresponding author Xavier Altafaj, of the University of Barcelona (UB) and Bellvitge Biomedical Research Institute (IDIBELL), researchers described using an amino acid, D-serine, to treat a child with a rare genetic disorder that affects neurons.

According to the notice, the researchers did use D-serine in lab work used as proof-of-concept; however, when it came time to try it in the patient, as a result of a “communication error:”

Continue reading Child took wrong compound for over a year after “communication error”

Estimate: Nearly 33,000 papers include misidentified cell lines. Experts talk ways to combat growing problem

Willem Halffman
Serge Horbach

Although most researchers realize too many are using misidentified cell lines in their work, they may be shocked to see the scope of the problem: Approximately 32,755 articles report on research that relied on misidentified cells, according to a new report in PLoS ONE. And even though more people may be aware of the problem, it hasn’t slowed it down: Most of the papers the authors flagged were written after 2000, and the number of new publications relying on misidentified cells continues to grow. We’ve tackled the issue — a 2015 poll of RW readers showed most believed the papers that report data from misidentified cell line should be either retracted or corrected, and our co-founders have recommended journals at least post “expressions of concern.” We spoke with the authors of the latest paper (also covered by The Scientist), Serge Horbach and Willem Halffman at Radboud University Nijmegen in the Netherlands.

Retraction Watch: You estimate more than 32,000 articles that used misidentified cells. That’s a very large number, to say the least — were you surprised at the scope of the problem?

Continue reading Estimate: Nearly 33,000 papers include misidentified cell lines. Experts talk ways to combat growing problem

Authors retract plant biology paper after they realized sample was contaminated

Plant biologists from China have retracted a 2013 paper in The Plant Cell after discovering that some of the plant material used was “inadvertently contaminated.”

According to the retraction notice, the authors believe the contamination affects the main conclusion of their paper. Continue reading Authors retract plant biology paper after they realized sample was contaminated

Project to “fact check” genetic studies leads to three more retractions. And it’s just getting started.

Jennifer Byrne

A project to identify studies doomed by problematic reagents has triggered three more retractions, bringing the total to five.

Jennifer Byrne, a scientist at the University of Sydney, who developed the the idea of double-checking the nucleic acid sequences of research materials — thereby ensuring studies were testing the gene in question — told Retraction Watch that all three retractions came after she started emailing journals in January  to alert them to the problems: Continue reading Project to “fact check” genetic studies leads to three more retractions. And it’s just getting started.

“We were devastated:” Authors retract paper after realizing they had used the wrong mice

Raymond Pasek and Maureen Gannon

Longtime readers of Retraction Watch may recall a 2011 post about a research team that retracted a paper after realizing that they had ordered the wrong mice. Maureen Gannon and Raymond Pasek of Vanderbilt University contacted us earlier this week to alert us to a similar case: Their retraction, earlier this month, of a 2016 paper from American Journal of Physiology – Endocrinology and Metabolism after discovering that “a colleague from another lab had mistakenly supplied us with the wrong transgenic mouse line.”

We strongly believe that sharing this example will encourage other researchers to do the right thing when a mistake is discovered and promote academic integrity,” they wrote. So we asked them to answer a few questions about their experience with “Connective tissue growth factor is critical for proper β-cell function and pregnancy-induced β-cell hyperplasia in adult mice,” a paper that has been cited twice, according to Clarivate Analytics’ Web of Science

Retraction Watch: How, and when, did you become aware of the error? Continue reading “We were devastated:” Authors retract paper after realizing they had used the wrong mice

Nuclear fuel container material isn’t as novel as it appeared in now-retracted paper

A layer of copper sprayed onto steel. (Figure 6 from “Structure and Mechanical Properties of Thick Copper Coating Made by Cold Spray“)

A paper describing the construction of a material that could be used in nuclear fuel containers has been retracted after the authors left out key details.

According to the editor, the omission made the authors’ method seem more novel than it was.

The material is described in “Structure and Mechanical Properties of Thick Copper Coating Made by Cold Spray.” It was published in the January 2016 issue of the Journal of Thermal Spray Technology.

According to the retraction notice, the authors did not specify in the paper how the first layer of copper was sprayed onto the steel:

Continue reading Nuclear fuel container material isn’t as novel as it appeared in now-retracted paper

What turned a cancer researcher into a literature watchdog?

Jennifer Byrne

Sometime in the middle of 2015, Jennifer Byrne, professor of molecular oncology at the University of Sydney, began her journey from cancer researcher to a scientific literature sleuth, seeking out potentially problematic papers.

The first step was when she noticed several papers that contained a mistake in a DNA construct which, she believed, meant the papers were not testing the gene in question, associated with multiple cancer types.  She started a writing campaign to the journal editors and researchers, with mixed success. But less than two years later, two of the five papers she flagged have already been retracted.

When asked why she spent time away from bench research to examine this issue, Byrne told us:  Continue reading What turned a cancer researcher into a literature watchdog?

Widely used brain tumor cell line may not be what researchers thought it was

Bengt Westermark
Bengt Westermark

Nearly 50 years ago, researchers in Uppsala, Sweden used cells from a patient to establish a brain tumor cell line that has become widely used. But a new study suggests that the most common source of that cell line used by scientists today may not be derived from that original patient’s tumor, raising questions about the results obtained in hundreds of studies.

In a new paper out today in Science Translational Medicine, Bengt Westermark, of Uppsala University, and colleagues describe what they found when they performed a forensic DNA analysis comparing the widely used version of the cell line to the original. The findings are consistent with those of other analyses in which cell lines turn out not to be what researchers thought, a problem we’ve focused some attention on.

Here’s an email interview with Westermark about the findings and their implications: Continue reading Widely used brain tumor cell line may not be what researchers thought it was

Genotyping mistake costs lab two papers and year of work

PNASResearchers are retracting two papers about molecular signalling in plants — including one from the Proceedings of the National Academy of Sciences (PNAS) — after discovering some inadvertent genotyping errors. But that was only after they used the problematic plants for an entire year without realizing they’d made a mistake.

In a pair of refreshingly transparent and detailed notices, the authors explain that the transgenic plants used in the papers included genotyping errors, which invalidated their findings. According to the notices, first author Man-Ho Oh generated the problematic transgenic plants, while corresponding author Steven C. Huber, based at University of Illinois, Urbana-Champaign (UIUC), took responsibility for omitting some critical oversight.

Huber told us that there were only two papers that used the transgenic plants in question, so no other retractions will be forthcoming.

Here’s the notice in PNAS for “Autophosphorylation of Tyr-610 in the receptor kinase BAK1 plays a role in brassinosteroid signaling and basal defense gene expression:”  Continue reading Genotyping mistake costs lab two papers and year of work

Poop paper flushed due to possible sample contamination

cover (3)The authors of a paper on a new probiotic strain of bacteria found in pig feces have retracted it from Animal Science Journal after discovering some of the bacteria might have been contaminated.

Readers likely know by now how easy it is for this to happen, as we frequently report on retractions due to similar reasons. Like other instances of mistaken cell identity, the authors of this 2013 paper realized the mistake following further tests of the bacteria used in the experiment.

The retraction for “Isolation, characterization, and effect of administration in vivo, a novel probiotic strain from pig feces

Continue reading Poop paper flushed due to possible sample contamination