Journal pulls parasite paper over potential for patient harm

Parasitology ResearchA journal has retracted a paper about a molecular diagnosis for leishmaniasis out of concern it could lead to incorrect clinical diagnoses. 

According to Parasitology Research, all data behind the figures in the main manuscript and supporting information are correct, but the authors’ misinterpretation of the data could lead doctors to diagnose patients incorrectly. 

Let’s take a look at the retraction notice, which tells us a bit more about the nature of the problem: Continue reading Journal pulls parasite paper over potential for patient harm

Corrections chip away at asbestos paper for conflicts of interest, “misleading” citation

EBPHThe journal Epidemiology Biostatistics and Public Health has issued back-to-back corrections for a 2015 paper after the authors failed to disclose conflicts of interest with the asbestos industry and included an “erroneous citation.”

The mistaken citation was more than just a clerical error, critics argue — it undermines one of the key arguments of the paper, “Critical reappraisal of Balangero chrysotile and mesothelioma risk,” which disputes claims that an asbestos mine in northwest Italy was responsible for numerous cases of an aggressive form of cancer called mesothelioma. The authors, led by Edward Ilgren formerly of Oxford University, claim that “myriad sources” of other forms of asbestos—rather than the asbestos produced at the mine, called chrysotile—exist in the region “to account for the alleged cases.”

However, according to a recently added correction, the citation does not support one of the authors’ claims about how other forms of asbestos arrived at the mine area.

Continue reading Corrections chip away at asbestos paper for conflicts of interest, “misleading” citation

Journal retracts bioelectronics paper for lack of credit to collaborators

S09565663The list of co-authors on a paper about a “bioelectronic composite” was apparently too sparse.

According to its retraction note — posted at the request of the editor-in-chief and the corresponding author — the paper failed to include some of the collaborators.

The Biosensors & Bioelectronics paper looks at a protein complex that could function as part of a “bio-hybrid” device, like a sensor or a solar cell. It has been cited only by its retraction according to Thomson Reuters Web of Science.

What went wrong in allotting credit for the work pretty straightforward, according to the note for “Monolayers of pigment–protein complexes on a bare gold electrode: Orientation controlled deposition and comparison of electron transfer rate for two configurations.” Here it is in full:

Continue reading Journal retracts bioelectronics paper for lack of credit to collaborators

Researchers’ productivity hasn’t increased in a century, study suggests

Screen Shot 2016-01-19 at 10.50.25 AMAre individual scientists now more productive early in their careers than 100 years ago? No, according to a large analysis of publication records released by PLOS ONE today.

Despite concerns of rising “salami slicing” in research papers in line with the “publish or perish” philosophy of academic publishing, the study found that individual early career researchers’ productivity has not increased in the last century. The authors analyzed more than 760,000 papers of all disciplines published by 41,427 authors between 1900 and 2013, cataloged by Thomson Reuters Web of Science.

The authors summarize their conclusions in “Researchers’ individual publication rate has not increased in a century:”

Continue reading Researchers’ productivity hasn’t increased in a century, study suggests

Methodology of paper linking vaccine to behavioral issues “seriously flawed,” says retraction

S0264410X

After temporarily removing a paper that suggested a link between the vaccine for the human papillomavirus (HPV) and behavioral issues, the journal has now retracted it.

Vaccine says the reason is “serious concerns regarding the scientific soundness of the article,” including flawed methodology and unjustified claims.

Christopher A. Shaw, a co-author on the paper and a researcher at the University of British Columbia, told us he has seen the notice, but doesn’t know the specific issues the journal had with the paper:

We still don’t know why [Editor in Chief] Dr Poland removed the article.

Here’s the retraction notice for “Behavioral abnormalities in young female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil:”

Continue reading Methodology of paper linking vaccine to behavioral issues “seriously flawed,” says retraction

Sanction for Toronto researchers upheld despite court challenge

Shereen Ezzat
Sylvia Asa
Sylvia Asa

A Toronto hospital network is keeping two researchers’ labs closed even after an Ontario court quashed part of a misconduct finding by the institution.

Some background: After the University Health Network found evidence of falsified data, Sylvia Asa stepped down as Program Medical Director of the Laboratory Medicine Program, the largest hospital diagnostic laboratory in Canada. Due to the investigation, UHN suspended the labs of Asa and her husband Shereen Ezzat. In response, Asa and Ezzat asked an Ontario court to quash the misconduct findings; last month, the court overturned two out of three findings, and asked UHN to reconsider its sanction against the pair.

According to the Toronto Star, on February 4th the UHN notified the researchers that the sanction against them would be upheld, and it would not reopen the researchers’ labs.

The Star spoke to the researcher’s lawyer, Brian Moher who  Continue reading Sanction for Toronto researchers upheld despite court challenge

Journal temporarily removes paper linking HPV vaccine to behavioral issues

1-s2.0-S0264410X16X00084-cov150hThe editor in chief of Vaccine has removed a paper suggesting a human papillomavirus (HPV) vaccine can trigger behavioral changes in mice.

The note doesn’t provide any reason for the withdrawal, although authors were told the editor asked for further review.

Two co-authors on the paper — about Gardasil, a vaccine against HPV — have previously suggested that aluminum in vaccines is linked to autism, in research a World Health Organization advisory body concluded was “seriously flawed.”

Approximately 80 million doses of Gardasil were administered in the U.S. between 2006 and 2015. Both the the WHO and the Centers for Disease Control and Prevention have ruled the vaccine to be safe — the CDC, for instance, calls it “safe, effective, and recommended.”

The journal published an uncorrected proof of “Behavioral abnormalities in young female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil” online on January 9th, 2016. In its place now is a note that says:

Continue reading Journal temporarily removes paper linking HPV vaccine to behavioral issues

Do scientists need audits?

Viraj Mane
Viraj Mane
Amy Lossie
Amy Lossie

If audits work for the Internal Revenue Service, could they also work for science? We’re pleased to present a guest post from Viraj Mane, a life sciences commercialization manager in Toronto, and Amy Lossie at the National Institutes of Health, who have a unique proposal for how to improve the quality of papers: Random audits of manuscripts.

Skim articles, books, documentaries, or movies about Steve Jobs and you’ll see that ruthlessness is the sine qua non of some of our greatest business leaders. It would be naïve to assume that scientists somehow resist these universal impulses toward leadership, competition, and recognition. In the white-hot field of stem cell therapy, where promising discoveries attract millions of dollars, egregious lapses in judgment and honesty have been uncovered in Japan, Germany, and South Korea. The nature of the offenses ranged from fraudulent (plagiarism and duplication of figures) to horrifying (female subordinates coerced into donating their eggs).

When a researcher embraces deception, the consequences extend well beyond the involved parties. Former physician Andrew Wakefield published a linkage between MMR vaccines and autism with overtly substandard statistical and experimental methods, while hiding how his financial compensation was tied to the very hysteria he helped unleash.

Let’s ask some hard questions. Continue reading Do scientists need audits?

Lancet retracts 24-year-old paper by “father of nutritional immunology” after reopening inquiry

lancetFollowing questions from outside experts, a retraction of a related paper, a university investigation and a court case, The Lancet has decided to retract a 1992 paper by Ranjit Kumar Chandra, the self-proclaimed “father of nutritional immunology.

In a lengthy retraction note included in the January 30 issue, the journal explains that:

the balance of probabilities in our judgment is that the reliability of the 1992 Lancet paper by Chandra can no longer be assured.

Chandra is objecting to the retraction.

This retraction was a long time coming, so sit back and relax as we fill in the backstory. Continue reading Lancet retracts 24-year-old paper by “father of nutritional immunology” after reopening inquiry

Ontario court quashes part of misconduct finding for prominent pair

Sylvia Asa
Sylvia Asa
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Shereen Ezzat

An Ontario court has quashed part of a misconduct finding against a prominent husband and wife team by the University Health Network in Toronto.

Last year, we reported that Sylvia Asa had stepped down from her position as Program Medical Director of the Laboratory Medicine Program at the UHN — the largest hospital diagnostic laboratory in Canada — after an investigation uncovered evidence of falsified data in two papers co-authored with her husband, Shereen Ezzat. Both of their research labs were also suspended as a result. The researchers subsequently appealed the decision.

On Friday Sunday, the Toronto Star reported that the court had set aside the finding of falsification, but upheld a finding of misconduct in the form of material non-compliance. It asked UHN to review the sanctions against both researchers, and cover their legal fees of $20,000.

Here’s the conclusion from the decision:

Continue reading Ontario court quashes part of misconduct finding for prominent pair