Lancet retracts 24-year-old paper by “father of nutritional immunology” after reopening inquiry

lancetFollowing questions from outside experts, a retraction of a related paper, a university investigation and a court case, The Lancet has decided to retract a 1992 paper by Ranjit Kumar Chandra, the self-proclaimed “father of nutritional immunology.

In a lengthy retraction note included in the January 30 issue, the journal explains that:

the balance of probabilities in our judgment is that the reliability of the 1992 Lancet paper by Chandra can no longer be assured.

Chandra is objecting to the retraction.

This retraction was a long time coming, so sit back and relax as we fill in the backstory. Continue reading Lancet retracts 24-year-old paper by “father of nutritional immunology” after reopening inquiry

“Innocent mistake” leads to bioethics article retraction

jbiA July article that incorrectly called out nine leading bioethics journals for their lack of availability to researchers in low- and middle-income countries is being pulled after editors of the indicted journals refuted the allegations.

The last author on the article, published in the Journal of Bioethical Inquiry, told us an “innocent mistake” and difficulty navigating a website led the authors to incorrectly note that nine journals had not made their contents available through the World Health Organization’s Health InterNetwork Research Initiative database (HINARI), which gives bioethicists who live in low- and middle-income countries access to research articles either free of charge or at reduced cost. The authors argued that the mistake didn’t affect the paper’s conclusions, but the journal disagreed, and opted to pull the paper entirely.

After searching through the database, first author Subrata Chattopadhyay mistakenly determined that the journals had not made their contents available through HINARI, when in fact they were listed but on a different part of the website.

Even with the error, the authors maintain that their conclusions remain sound and that the field is shaped by a “hegemony of Western bioethics.” Continue reading “Innocent mistake” leads to bioethics article retraction

EMBO takes back Voinnet’s award, investigates other awardee who just lost a Nature Genetics paper

Screen Shot 2016-01-28 at 11.41.20 AMEMBO has taken back an award given to beleaguered plant biologist Olivier Voinnet in 2009, and is investigating a recent grantee who had a paper retracted from Nature Genetics yesterday.

The European Molecular Biology Organization (EMBO) “promotes excellence in the life sciences” in Europe, in part by awarding prizes to promising young scientists. Voinnet and Sonia Melo earned their awards by exhibiting potential as young scientists studying genetics — of plants and cancer, respectively — but now EMBO is skeptical of the papers that formed the basis of their applications.

Melo’s Installation Grant from EMBO was announced just last month, and consists of 50,000 Euros annually for three to five years. She is currently based at the University of Porto, in Portugal.

Voinnet’s problems are well-documented on this blog — 21 corrections, seven retractions, and two investigations. Earlier this week, we reported that the Swiss National Science Foundation had cut off Voinnet’s funding, and banned him for three years. Continue reading EMBO takes back Voinnet’s award, investigates other awardee who just lost a Nature Genetics paper

Authorship dispute fells membrane paper

no spine minimum. full size. Editor: Barbara Sydow JEM: Clay RTP: Cynthia Porath jpcbfk

A membrane paper has been retracted only two months after publication in the Journal of Physical Chemistry B because of an authorship dispute.

The paper, “Magnetic Interaction of Transition Ion Salts with Spin Labeled Lipid Membranes: Interplay of Anion-Specific Adsorption, Electrostatics, and Membrane Fluidity,” has not been cited, according to Thomson Scientific’s Web of Knowledge. (It appears to be taken down entirely, but it looks like you can read its abstract here.)

Here’s the entire — very short — note:

Continue reading Authorship dispute fells membrane paper

Sharing data is a good thing. But we need to consider the costs.

Liz Wager

Last week, the International Committee of Medical Journal Editors proposed requiring authors to share deidentified patient data underlying the published results of clinical trials within six months of publication. The proposal has earned much support but also some concerns – for example that other scientists might poach the findings, acting as the New England Journal of Medicine dubbed “research parasites.” Elizabeth Wager, a member of the board of directors of our parent organization, disagrees with that concern, but raises another issue – namely, the unintended consequences of data sharing on other, more effective initiatives to make reporting more transparent.

The recent proposal from the ICMJE may appear, at first glance, a positive step towards better clinical trial reporting. However, I’m concerned that this new requirement might undermine other more effective initiatives to increase the efficiency of research, such as the publication of protocols and full study reports. Here’s why.

All actions have costs, risks, and benefits: Making partial data sharing a condition of publication is no exception. The costs are hard to quantify but undoubtedly not trivial.  Putting clinical data into a usable format and making it meaningful to other researchers requires considerable time and effort by knowledgeable people. To this must be added the costs of establishing and maintaining suitable repositories and of checking compliance.

I’m not saying that open data does not have any benefits. Continue reading Sharing data is a good thing. But we need to consider the costs.

Investigation of undisclosed conflicts in catheter paper uncovers flawed data, too

cov150hAn investigation into a paper that compared infection rates from different types of central lines started with an allegation about a failure to disclose a conflict of interest, and ended up concluding that the science in the paper was flawed.

The 2013 paper — now retracted by the American Journal of Infection Control — suggested a particular kind of connector between the catheter and the patient could reduce some of the notoriously deadly bloodstream infections associated with the procedure, according to a press release that publicized the work. But last year, the journal issued an expression of concern for the paper, noting there were questions about the data. The retraction note reveals an investigation at Georgia Regents University — now known as Augusta University — started looking into undisclosed conflicts of interest in the paper, and ultimately concluded the science was flawed.

Here’s the retraction note, published in the January 1st 2016 issue of the journal, for “Comparison of central line-associated bloodstream infection rates when changing to a zero fluid displacement intravenous needleless connector in acute care settings

Continue reading Investigation of undisclosed conflicts in catheter paper uncovers flawed data, too

Seralini paper claiming GMO toxicity disappears after journal domain expires

SJASA paper claiming genetically modified corn may be toxic over long periods has disappeared one day after it was presented at a press conference, after the journal’s domain name expired.

The paper, co-authored by Gilles Seralini — who has published controversial research showing harms of GM food — appeared in the Scholarly Journal of Agricultural Sciences (SJAS). On Tuesday, the Committee for Independent Research and Information on Genetic Engineering (Criigen) scheduled a press conference about the findings, noting the finding presented

new scientific data on Bt toxins and a thorough study of the records show that this GMO Bt maize is most probably toxic over the long term.

But on Wednesday January 27, the journal’s domain name expired. This isn’t a retraction per se, but a disappearance. Now, any link to the study “Pathology reports on the first cows fed with Bt176 maize (1997–2002)” goes to this page, which says in the bottom right corner: Continue reading Seralini paper claiming GMO toxicity disappears after journal domain expires

What to do when you make a mistake? Advice from authors who’ve been there

cpp-150After a group of researchers noticed an error that affected the analysis of a survey of psychologists working with medical teams to help pediatric patients, they didn’t just issue a retraction — they published a commentary explaining what exactly went wrong.

The error was discovered by a research assistant who was assembling a scientific poster, and noticed the data didn’t align with what was reported in the journal. The error, the authors note, was:

an honest one, a mistake of not reverse coding a portion of the data that none of the authors caught over several months of editing and conference calls. Unfortunately, this error led to misrepresentation and misinterpretation of a subset of the data, impacting the results and discussion.

Needless to say, these authors — who use their “lessons learned” to help other researchers avoid similar missteps — earn a spot in our “doing the right thing” category. The retraction and commentary both appear in Clinical Practice in Pediatric Psychology.

Their first piece of advice in “Retraction experience, lessons learned, and recommendations for clinician researchers” — assume errors will happen, and not vice versa: Continue reading What to do when you make a mistake? Advice from authors who’ve been there

Following an earlier investigation, GW biologist earns two expressions of concern

3.cover (1)The Journal of Biological Chemistry has flagged two papers by a George Washington University cancer biologist with expressions of concern, following an investigation completed by the university in 2014.

The notes contain little specific information; all we know is that there are questions about the data and conclusions in the papers.

The last author on both papers is Rakesh Kumar, who adds these EoCs to a count that includes, according to our records, three retractions and five corrections. Plus an $8 million lawsuit against his employer for emotional distress when they put him on leave from his position as department chair.

The studies — “Stimulation of inducible nitric oxide by hepatitis B virus transactivator protein HBx requires MTA1 coregulator” and “Regulation of NF-B circuitry by a component of the nucleosome remodeling and deacetylase complex controls inflammatory response homeostasis” — have been cited 22 times and 33 times respectively, according to Thomson Scientific’s Web of Knowledge.

The expression of concern is the same for both papers — and matches others that we’ve seen from JBC:

Continue reading Following an earlier investigation, GW biologist earns two expressions of concern

Paper on the adhesiveness of a material doesn’t stick

1-s2.0-S0169433215X00213-cov150hApplied Surface Science has retracted an article that looks at the structure of thin tungsten-titanium coating, because it was submitted without all of the co-authors’ consent.

According to the introduction of the paper, “Structure adhesion and corrosion resistance study of tungsten bisulfide doped with titanium deposited by DC magnetron co-sputtering,” such thin films are “widely used as a surface treatment for optimizing base material properties.”

Here’s the retraction note in full, published in the September issue of the journal:

Continue reading Paper on the adhesiveness of a material doesn’t stick