Category: cell biology

Exclusive: University of Glasgow seeking retraction of multiple papers after findings of image manipulation

Miles Houslay

The University of Glasgow is requesting the retraction of multiple papers by a pharmacology researcher who held various positions there for more than a quarter century.

The story begins in December 2016, when biostatistician Steven McKinney posted on PubPeer about a paper by the researcher, Miles Houslay, in the Journal of Biological Chemistry. That paper was eventually retracted in August 2020, but not before McKinney posted a comment on Retraction Watch that caught the eye of the pseudonymous Clare Francis.

Francis pointed us to comments about a total of eight of Houslay’s papers at that time. And in August 2020, when the JBC retraction appeared, Francis forwarded those to the King’s College, London, where Houslay is listed as having a faculty position, and the University of Glasgow, which he left in 2011.

Continue reading Exclusive: University of Glasgow seeking retraction of multiple papers after findings of image manipulation

Caught Our Notice: A team from Harvard, Cornell, Cambridge, HHMI, and UCSF can’t reproduce a paper’s findings

What Caught Our Attention: Any time there’s an issue with a paper co-authored by researchers from such high-profile institutions as Harvard, Cornell, and the University of Cambridge, we take notice. In this case, the group — which included Laurie Glimcher, then-dean at Cornell, now president of the Dana-Farber Cancer Institute — chose to retract a 2013 paper from a Cell journal after learning they couldn’t reproduce some of the experiments. Continue reading Caught Our Notice: A team from Harvard, Cornell, Cambridge, HHMI, and UCSF can’t reproduce a paper’s findings

Caught Our Notice: Duplicates, errors prompt two retractions for same author

Titles: 1) Angiopoietin-Like 4 Confers Resistance to Hypoxia/Serum Deprivation-Induced Apoptosis through PI3K/Akt and ERK1/2 Signaling Pathways in Mesenchymal Stem Cells

2) Novel Mechanism of Inhibition of Dendritic Cells Maturation by Mesenchymal Stem Cells via Interleukin-10 and the JAK1/STAT3 Signaling Pathway

What Caught Our Attention: In the span of 48 hours, PLOS ONE retracted two papers this month that were co-authored by Bo Yu, based at Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment and The Second Affiliated Hospital of Harbin Medical University in China. Both notices cite multiple duplications and errors, and conclude:

Continue reading Caught Our Notice: Duplicates, errors prompt two retractions for same author

Caught Our Notice: “The first author cut the thermoprinter paper printout into pieces and reassembled them”

Title: A mitochondrial ferredoxin is essential for biogenesis of cellular iron-sulfur proteins

What Caught Our Attention: Here’s a cut-and-paste issue that gave us pause. The authors of an 18-year-old paper in PNAS corrected it after realizing some bands in a figure were duplicated (an issue raised on PubPeer one year ago). It turns out, the first author had cut the paper into pieces and reassembled them to present the blots in the “desired order,” and some had become duplicated by mistake. The overall results were unaffected, so the journal swapped the image with a corrected version. Continue reading Caught Our Notice: “The first author cut the thermoprinter paper printout into pieces and reassembled them”

Caught Our Notice: Swiss group loses 4th paper for data manipulation

Title: Dysferlin Interacts with Histone Deacetylase 6 and Increases alpha-Tubulin Acetylation

What Caught Our Attention:  After losing three articles for data manipulation, Michael Sinnreich has retracted another paper in PLoS ONE.  All four retractions share some of the same authors, including Bilal Azakir and Sabrina Di Fulvio, who is listed as the first author on the latest retraction. None of the notices have identified a person responsible for the data manipulation. Three years ago, PubPeer user had flagged some of the figures mentioned in the notice — noting that he was “led to this paper by a story on Retraction Watch” — most likely, a 2014 post that flagged an ongoing discussion about one of Sinnreich’s papers on PubPeer. Continue reading Caught Our Notice: Swiss group loses 4th paper for data manipulation

Caught Our Notice: Journals still (slowly) purging archives of bad cell line studies

Via Wikimedia

Title: Tanshinone IIA Induces Apoptosis in Human Oral Cancer KB Cells through a Mitochondria-Dependent Pathway

What Caught Our Attention: Thousands of papers have relied on contaminated or wrong cell lines, a problem journals have not been particularly proactive in addressing. So far, only a few studies have been retracted for using misidentified cell lines. Continue reading Caught Our Notice: Journals still (slowly) purging archives of bad cell line studies

Caught Our Notice: After ORI flags a paper by former grad student, university flags another

Via Wikimedia

Title: The L3MBTL3 Methyl-Lysine Reader Domain Functions As a Dimer

What Caught Our Attention: Six months ago, the U.S. Office of Research Integrity (ORI) determined that former graduate student Brandi Baughman had doctored 11 figures in a PLOS ONE article, which was retracted shortly after.  The PLOS ONE paper listed two affiliations for Baughman — the National Institute of Environmental Health Sciences and the University of North Carolina, Chapel Hill (UNC); now UNC has triggered a second retraction of a paper co-authored by Baughman, also due to research misconduct. Although the ORI notice makes no mention of this additional paper, the agency recently took a “targeted approach” by not issuing comprehensive findings of misconduct for one researcher, in order to conserve resources. Of course, sometimes universities make findings that don’t meet the ORI’s bar, too. Continue reading Caught Our Notice: After ORI flags a paper by former grad student, university flags another

Caught Our Notice: A retraction that is “useful for investigators”

Via Wikimedia

Title:  Yeast CAF-1 assembles histone (H3-H4) 2 tetramers prior to DNA deposition

What Caught Our Attention: Informative retraction notices can be infrequent, but rarer still are notices that fulfill an oft-ignored function: To be a source of learning for others in the field. Here, the authors offer a nearly 800-word “detailed description of the issues” with “some observations that may be useful for investigators conducting similar studies.” These authors embraced the retraction process, carefully explaining their findings or the lack thereof, for each figure from their now-retracted paper.     Continue reading Caught Our Notice: A retraction that is “useful for investigators”

Caught Our Notice: Investigation finds “accidental mistakes” in PNAS stem cell paper

Via Wikimedia

When Retraction Watch began in 2010, our co-founders Ivan Oransky and Adam Marcus quickly realized they couldn’t keep up with the hundreds of retractions that appeared each year.  And the problem has only gotten worse — although we’ve added staff, the number of retractions issued each year has increased dramatically. According to our growing database, just shy of 1,000 retractions were issued last year (and that doesn’t include expressions of concern and errata). So to get new notices in front of readers more quickly, we’ve started a new feature called “Caught our Notice,” where we highlight a recent notice that stood out from the others. If you have any information about what happened, feel free to contact us at [email protected].

Title: Combined hydrogels that switch human pluripotent stem cells from self-renewal to differentiation 

What caught our attention: Continue reading Caught Our Notice: Investigation finds “accidental mistakes” in PNAS stem cell paper

Journal flags cancer paper from Karolinska researchers

A journal has issued an expression of concern (EOC) for a 2011 cancer paper, while Karolinska Institutet investigates “concerns” about some of the data.

After the Journal of Cell Science (JCS) received a tip from a reader, it investigated, but was unable to resolve the concerns. So the journal asked KI–where all the authors work–to investigate further, and issued an EOC to alert readers that there may be an issue with the paper.

According to the notice, the questions center on data from Fig. 1A, but the notice does not specify the nature of the concerns. The 2011 paper received a correction in 2016, which cites inadvertent figure duplication.

Earlier this year, the paper’s last author Boris Zhivotovsky and second author Helin Vakifahmetoglu-Norberg retracted a 2008 paper from Oncogene over potential image duplication. That retraction caught our attention because it was prompted by a 2016 correction to the paper, which had raised additional questions about potential duplication; ultimately, the authors retracted both the paper and its correction.

Here’s the expression of concern for the 2011 JCS paper: Continue reading Journal flags cancer paper from Karolinska researchers