Category: clinical study retractions

Author dispute retracts paper suggesting NSAIDs curb growth in rats

jpedorthoThe corresponding author asked the Journal of Pediatric Orthopaedics to retract an article that found popular pain medicines can curb growth in rats, in light of an unresolved authorship dispute.

The article, “Nonsteroidal Anti-Inflammatory Drugs Cause Inhibition of the Growth Plate in Cultured Rat Metatarsal Bones,” details preliminary results that indicate nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce growth in rat bones in a dose-dependent manner, suggesting caution in treating chronic inflammatory diseases in children. The editor told us the paper was “highly rated” by reviewers and the results were “never in question,” but the senior author asked to pull the paper after failing to resolve a dispute with a researcher who asked to be added as an author.

According to the notice:  Continue reading Author dispute retracts paper suggesting NSAIDs curb growth in rats

Raw files help fix 2003 figure by heart researcher accused of fraud

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A researcher accused of misconduct by an anonymous Japanese blogger has corrected a 2003 paper in Circulation Research, after providing a university investigation with the original source files.

Allegations of fraud have dogged Shokei Kim-Mitsuyama for years, and even caused him to step down from his position as editor in chief at another journal. However, Kim-Mitsuyama and his colleagues call the latest correction a “mistake,” which didn’t affect any of the paper’s conclusions.

We’ve unearthed a total of five publications co-authored by Kim-Mitsuyama that have earned corrections, the latest of which cites an investigation by the university:

Continue reading Raw files help fix 2003 figure by heart researcher accused of fraud

Authors retract, replace highly cited JAMA Psych paper for “pervasive errors”

JAMA PsychiatryAuthors have retracted a highly cited JAMA Psychiatry study about depression after failing to account for some patient recoveries, among other mistakes.

It’s a somewhat unusual notice — it explains that the paper has been retracted and replaced with a new, corrected version.

The study, which included 452 adults with major depressive disorder, concluded that cognitive therapy plus medication works better to treat depression than pills alone. But after it was published, a reader pointed out that some of the numbers in a table were incorrect. The authors reviewed the data and redid their analysis, and discovered “a number of pervasive errors.”

The notice (termed “notice of retraction and replacement”) explains the consequences of those errors:

Continue reading Authors retract, replace highly cited JAMA Psych paper for “pervasive errors”

Journals retract two heart papers with “nearly identical” abstracts

Screen Shot 2016-02-22 at 4.46.17 PMJournals have retracted two papers after realizing that they contain “nearly identical” abstracts and introductions, published only months apart. 

The two retracted papers, along with a third that also contains similar text, all conclude that a certain polymorphism could signal a risk for coronary artery disease among Chinese people, though each paper presents different data. The papers do not have any authors in common; the first authors are all based at different hospitals in China. The editor in chief of one journal told us that some of the reviewers did not use institutional email addresses, which leaves open the possibility that they were fake emails, and the peer-review process was compromised.

Here’s the first retraction notice, for “Fibroblast growth factor receptor 4 polymorphisms and susceptibility to coronary artery disease,” published in DNA and Cell Biology. The notice states the paper contains:

Continue reading Journals retract two heart papers with “nearly identical” abstracts

NEJM quickly corrects disclosure statement, errors in diabetes paper

NEJM LogoAfter publishing a paper about neuropathy in diabetic patients last week, The New England Journal of Medicine (NEJM) immediately corrected it after editors learned of errors and some missing disclosures within the article.

The notice explains that the sole author of the paper, “Diabetic Sensory and Motor Neuropathy,” reported incorrect doses for several medications, and received royalties for the tool to measure quality of life used in the paper. The author told us all the declarations were “discussed in detail” between him and the journal, and both parties agreed to the final decision. 

Let’s take a look at the lengthy correction notice — what some of our readers might call a “mega-correction:” Continue reading NEJM quickly corrects disclosure statement, errors in diabetes paper

Three HER2-cancer review papers tagged with expressions of concern

The Oncologist Her 2 expression of concern

The Oncologist has tagged three review papers that share a first author with an expression of concern. The three papers, which have together been cited more than 1,000 times, focus on HER2, a gene that can contribute to breast cancer.

Though the papers contain errors, the conclusions — about how the HER2 gene serves as a predictive factor for breast cancer, and a target for therapies — remain unchanged, according to the EOC. The editor of the journal notes that the conclusions of the papers have been confirmed by other publications. Two of the papers are more than 10 years old, and today many patients continue to be treated with medications that target HER2, such as Herceptin.

Here’s the expression of concern:

Continue reading Three HER2-cancer review papers tagged with expressions of concern

Pharmacology journal pulls paper because third party “compromised” peer review

BJCP CoverThe British Journal of Clinical Pharmacology (BJCP) has retracted a 2015 paper about treating heart failure after deciding its peer review process had been compromised.

This paper is one of the many we’ve noticed lately that have been felled by the actions of a “third party” — in this case, a manuscript editing company called EditPub.

The newly retracted paper, “rhBNP therapy can improve clinical outcomes and reduce in-hospital mortality compared with dobutamine in heart failure patients: a meta-analysis,” has not yet been cited, according to Thomson Reuters Web of Science.

Here’s the retraction note, which tells us a bit more: Continue reading Pharmacology journal pulls paper because third party “compromised” peer review

“Science advances incrementally:” Researchers who debunked gay canvassing study move field forward

David Broockman
Joshua Kalla

How easy is it to change people’s minds? In 2014, a Science study suggested that a short conversation could have a lasting impact on people’s opinions about gay marriage – but left readers disappointed when it was retracted only months later, after the first author admitted to falsifying some of the details of the study, including data collection. We found out about the problems with the paper thanks to Joshua Kalla at the University of California, Berkeley and David Broockman at Stanford University, who tried to repeat the remarkable findings. Last week, Kalla and Broockman published a Science paper suggesting what the 2014 paper showed was, in fact, correct – they found that 10-minute conversations about the struggles facing transgender people reduced prejudices against them for months afterwards. We spoke with Kalla and Broockman about the remarkable results from their paper, and the shadow of the earlier retraction.

Retraction Watch: Let’s start with your latest paper. You found that when hundreds of people had a short (average of 10 minutes) face-to-face conversation with a canvasser (some of whom were transgender), they showed more acceptance of transgender people three months later than people with the same level of “transphobia” who’d talked to the canvasser about recycling. Were you surprised by this result, given that a similar finding from Michael LaCour and Donald Green, with same-sex marriage, had been retracted last year? Continue reading “Science advances incrementally:” Researchers who debunked gay canvassing study move field forward

Peer reviewer stole text for her own dentistry paper, says journal investigation

Journal of Conservative DentistryFollowing a “thorough investigation,” the Journal of Conservative Dentistry (JCD) has retracted a paper after concluding that the first author stole the text from another paper when peer reviewing it for a different journal. 

The JCD decided that the 2013 paper about white spot lesions and inhibiting the growth of the bacteria Streptococcus mutans in the mouth is a “verbatim copy” of a paper that was rejected by the International Journal of Paediatric Dentistry in 2012 but published by The Journal of Clinical Pediatric Dentistry in 2014.

The first author denied the charges, saying she had finished the paper before reviewing the other, which she suggested rejecting.

Let’s take a look at the retraction note, which tells us more about the journal’s investigation: Continue reading Peer reviewer stole text for her own dentistry paper, says journal investigation

Paper on GI cancers linked to AIDS pulled for errors that upped tumor incidence

gastroGastroenterology has retracted a 2012 article on GI cancers associated with AIDS after the authors, from the National Cancer Institute, acknowledged that a “programming” error led them to overestimate the incidence of the tumors.

The paper, “Increased Risk of Stomach and Esophageal Malignancies in People With AIDS,” received a significant amount of attention when it first appeared, including a press release from the American Gastroenterological Association and several news articles. Here are its primary findings, according to the abstract:  Continue reading Paper on GI cancers linked to AIDS pulled for errors that upped tumor incidence