Category: basic life sciences retractions

More questions arise over gene-editing tool

13238A new letter signed by 20 researchers is casting additional doubts on the validity of a potentially invaluable lab tool — and alleges the lab that produced the initial results turned them away when they tried to replicate its findings in mammalian cells.

In a letter published this week in Protein & Cell, the researchers add their voices to the critics of the gene-editing technique, first described earlier this year in Nature Biotechnology.

The researchers outline their attempts to apply the technique — known as NgAgo — to a variety of cell types, which fell short:

Continue reading More questions arise over gene-editing tool

Nature Cell Bio paper may be headed for retraction

ncbA Nature Cell Biology paper published only a few months ago by prominent researchers in Taiwan has sparked a heated discussion on PubPeer, which now includes a comment allegedly from an author saying they have requested its retraction.

Although a representative of the journal wouldn’t confirm to us that the authors had requested a retraction, the comment on PubPeer says the paper contains several figures that were “inappropriately manipulated” by the first author.

Here’s the full comment on PubPeer, tagged as coming from one of the authors of the paper:

Continue reading Nature Cell Bio paper may be headed for retraction

Two Harvard-led groups pull well-cited cancer papers for duplication

the-journal-of-clinical-investigationTwo sets of authors based largely at Harvard Medical School have each retracted a paper for duplication in the same journal.

Both papers — which are more than a decade old — were pulled in The Journal of Clinical Investigation on November 1 by their respective corresponding authors.

One paper’s last author told us it was difficult to identify how the duplications occurred since the study took place so long ago, but added that multiple experiments had corroborated the results.

Here’s the first retraction notice for “Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism:” Continue reading Two Harvard-led groups pull well-cited cancer papers for duplication

Genetics study flagged for reliability issues by Frontiers journal

frontiers-in-geneticsA genetics journal has issued an expression of concern (EOC) for a study after an investigation by its chief editors.

According to the notice in Frontiers in Genetics, the authors of the paper — based at Hokkaido University in Sapporo, Japan — are conducting further experiments to resolve the issues raised by the journal’s investigation.

In February, the same paper received a corrigendum due to errors in the assembly of one of the figures.

Here’s the EOC, issued earlier this week: Continue reading Genetics study flagged for reliability issues by Frontiers journal

Family decries publication of child’s picture in open access journal

indian-journal-of-dermatology-venereology-and-leprologyAn author of a paper about a boy with a rare genetic disorder has retracted it after the patient’s family revoked permission to use his photo.

The 2012 paper in the Indian Journal of Dermatology, Venereology and Leprology (IJDVL) told the tale of a 14-year old boy with Delleman syndrome, a condition that often results in the development of cysts within the cavities of the skull, leading to malformations in the eyes, brain, and skin.

Mabel Nocito, the study’s first and corresponding author from Hospital Churruca in Buenos Aires, Argentina told us the parents initially gave permission to publish their son’s picture, but then became concerned when they realized the paper was freely accessible: Continue reading Family decries publication of child’s picture in open access journal

Journal pulls plug on paper that predicts person’s death, against authors’ objections

frontier-in-human-neuroscienceSome people can look at an old photograph of a person — say, of your grandmother in elementary school — and tell whether the person is today alive or dead, according to a paper published last spring.

If that sounds too weird to be true…well, it might be. The journal editors have retracted the paper for not having enough evidence to back up its claims, despite the authors’ objections.

Here’s the retraction notice for “Prediction of Mortality Based on Facial Characteristics,” published in Frontiers in Human Neuroscience:

Continue reading Journal pulls plug on paper that predicts person’s death, against authors’ objections

Authors retract third cancer paper for missing original data

international-journal-of-oncologyResearchers have retracted their third paper due to missing original data, following an investigation at their former institution in New York.

We’ve previously reported on two retractions of papers co-authored by Bhagavathi Narayanan and Narayanan K. Narayanan, previously based at the New York University (NYU) School of Medicine. The studies were pulled when the pair couldn’t provide original images to investigators at NYU School of Medicine. One author has blamed the lack of original data on the abrupt closure of her previous institution in 2004, after it allegedly misspent millions in federal grants. 

However, the latest retraction affects a paper published eight years later in the International Journal of Oncology. Its coauthors include Bhagavathi Narayanan, Narayanan K. Narayanan and Rajkishen Narayanan; we haven’t been able to uncover if there is a relation between them.

A spokesperson for the NYU School of Medicine sent us this statement: Continue reading Authors retract third cancer paper for missing original data

Eye researcher loses fourth paper for misconduct following Georgia, VA investigation

Azza B. El-Remessy
Azza B. El-Remessy

A biologist at the University of Georgia has lost a paper after an investigation revealed she had tampered with three images.

In 2014, Azza El-Remessy notched three retractions for a series of image errors. Now, a fourth retraction notice, and an expression of concern, explain there has been an investigation into her work. The investigation — conducted by two Georgia institutions, along with the Charlie Norwood Veterans Affairs Medical Center, where El-Remessy has additional appointments — has found evidence of misconduct.

The retraction notice for “Oxidative stress inactivates VEGF survival signaling in retinal endothelial cells via PI 3-kinase tyrosine nitration” explains:

Continue reading Eye researcher loses fourth paper for misconduct following Georgia, VA investigation

Neuro journal pulls paper due to doubts over authors’ identities

international-journal-of-neuroscienceA neuroscience journal has retracted a 2015 study after noticing the author list changed from submission to publication.

According to the retraction notice in the International Journal of Neuroscience, “conflicting messages” were conveyed between the study’s alleged two lead authors, causing the journal to doubt the provenance of the paper.

All the study’s authors are listed as affiliated with The People’s Hospital of Laiwu City in Shandong, China.

Here’s the retraction notice, issued earlier this year: Continue reading Neuro journal pulls paper due to doubts over authors’ identities

Springer, BMC retracting nearly 60 papers for fake reviews and other issues

springerIn a massive cleanup, Springer and BioMed Central announced today they are retracting 58 papers for several reasons, including manipulation of the peer-review process and inappropriately allocating authorship.

The papers appeared in seven journals, and more are under investigation.

In a release issued today, the publishers note: Continue reading Springer, BMC retracting nearly 60 papers for fake reviews and other issues