Category: investigator error

Researchers mistakenly administer three-fold higher dose of anesthesia

Researchers have retracted a 2016 paper after discovering that they accidentally administered three times the reported dose of anesthesia to rats.

In the Experimental Physiology paper, the authors set out to mathematically map how rats’ blood pressure changes under different conditions, which required the rats to be anesthetized. But their findings were called into question when they found the rats had received a much higher concentration of anesthesia than intended. According to the notice, this higher dose compromised the “objectives of the experiment.”

The corresponding author Karol Ondrias, from the Institute of Molecular Physiology and Genetics at the Slovak Academy of Sciences in Bratislava, told us how the dosing error occurred: Continue reading Researchers mistakenly administer three-fold higher dose of anesthesia

“Think of the unthinkable:” JAMA retraction prompts author to urge others to share data

A few months ago, a researcher told Evelien Oostdijk there might be a problem with a 2014 JAMA study she had co-authored.

The study had compared two methods of preventing infection in the intensive care unit (ICU). But a separate analysis had produced different results.

Oostdijk, from the University Medical Center Utrecht in The Netherlands, immediately got to work to try to figure out what was going on. And she soon discovered the problem: The coding for the two interventions had been reversed at one of the 16 ICUs. This switch had “a major impact on the study outcome,” last author Marc Bonten, also from the University Medical Center Utrecht, wrote in a blog post about the experience yesterday, because it occurred at “one of the largest participating ICUs.”

When Oostdijk and a researcher not involved in the study analyzed the data again, they discovered a notable difference between the revised and original findings: The new analysis revealed that one of the interventions had a small but significant survival benefit over the other.

Oostdijk and Bonten, who supervised the re-analysis, notified their colleagues of the revised study outcomes and contacted the journal requesting a retraction and replacement, which was published yesterday in JAMA.

According to the notice of retraction and replacement:

Continue reading “Think of the unthinkable:” JAMA retraction prompts author to urge others to share data

Chemistry papers challenged a paradigm — until the authors spotted a pivotal error

Several years ago, a group of four chemists believed they had stumbled upon evidence that contradicted a fairly well-established model in fluid dynamics.

Between 2013 and 2015, the researchers published a series of four papers detailing their results — two in ACS Macro Letters and two in Macromolecules. Timothy P. Lodge, the journals’ editor and a distinguished professor at the University of Minnesota in Minneapolis, explained that the results were “somewhat controversial,” because they appeared to contradict the generally accepted model for how some polymer fluids move.

Indeed, the papers sparked debate between the authors and other experts who questioned the new data, arguing it didn’t upend the previous model.

Then, in 2015, the authors realized their critics might be correct.  Continue reading Chemistry papers challenged a paradigm — until the authors spotted a pivotal error

Authors who retract for honest error say they aren’t penalized as a result

Daniele Fanelli

Are there two types of retractions? One that results from a form of misconduct, such as plagiarism or manipulating figures, and another that results from “honest errors,” or genuine mistakes the authors have owned up to? More and more research is suggesting that the community views each type very differently, and don’t shun researchers who make mistakes and try to correct the record. In yet another piece of evidence, Daniele Fanelli and his colleagues recently published the results of their interviews with 14 scientists who retracted papers for honest errors between 2010-2015. Although much of what scientists said affirmed what Fanelli – based at METRICS (the Meta-Research Innovation Center) at Stanford University – has long argued about retractions due to honest error, some of their answers surprised him.

Retraction Watch: We’ve seen the community reward scientists who retract papers for honest error, including a 2013 paper that showed no citation penalty for researchers who self-retract. Yet the interviewees said they were surprised to realize there weren’t any negative consequences to their self-retractions (some even got kudos for doing it). Why do you think people don’t realize how the community will view honest error?

Continue reading Authors who retract for honest error say they aren’t penalized as a result

Patient misdiagnosed with rare neurological side effect in retracted case study

When two surgeons in Greece learned that a patient had developed a rare side effect following weight loss surgery, they were eager to publish the case.

After extensive testing, the patient was diagnosed with Wernicke’s encephalopathy—a neurological disorder caused by thiamine deficiency—following a sleeve gastrectomy procedure. As the authors note in the paper, they had seen only eight other cases following the procedure in the literature.

It turns out, theirs was not the ninth. After the patient unfortunately died, he was examined by a coroner, who ruled he did not, in fact, have Wernicke’s encephalopathy. So Dimitrios Manatakis and Nikolaos Georgopoulos, both based at Athens Naval and Veterans Hospital in Greece, have retracted their 2014 case study.

When the first learned of the patient, the authors wanted to alert the surgical community to the case, given the rarity of this side effect, Manatakis told us: Continue reading Patient misdiagnosed with rare neurological side effect in retracted case study

Physics paper’s results off by factor of 100

Researchers from China have retracted a physics paper after realizing an error led them to report results that were nearly 100 times too large.

What’s more, the authors omitted key findings that would enable others to reproduce their experiments.

According to the notice, the authors used a value to calculate a feature of electrons—called mobility—that “was approximately 100 times too small,” which led to results that were “100 times too large.” The notice also details several gaps in the presentation of experimental results, which preclude others from duplicating the experiments.

Here’s the retraction notice for “Bulk- and layer-heterojunction phototransistors based on poly[2-methoxy-5-(2′-ethylhexyloxy-p-phenylenevinylene)] and PbS quantum dot hybrids:” Continue reading Physics paper’s results off by factor of 100

Neuroscientist flags errors in his days-old paper “for the sake of science integrity”

Only days after his paper was published online, a neuroscientist has posted a comment on PubMed alerting readers to several duplication errors.

Despite the issues, which the researcher says were introduced into the final manuscript after peer review, he reassured readers that they do not influence the final conclusions in the paper.

On February 9, ten days after the article came online, corresponding author Garret Stuber at the University of North Carolina at Chapel Hill wrote a detailed comment on PubMed Commons, explaining that the “research community” had brought four figure-related errors to his attention. After investigating the concerns, Stuber discovered that the problems emerged after the peer-review process, “while revising the manuscript to comply with Nature Neuroscience’s final formatting guidelines.” In his note, he outlined the specific duplication issues that arose, which he says he plans to detail to the journal in a formal corrigendum letter.

Stuber alerted the scientific community about his PubMed comment via Twitter: Continue reading Neuroscientist flags errors in his days-old paper “for the sake of science integrity”

Columbia University probe prompts retraction of cardiovascular paper

A journal has retracted a 2011 study at the request of Columbia University.

According to Jeanine D’Armiento, the study’s last author, the newly retracted paper in Clinical Science contained a figure from a Journal of Hypertension paper published by the same authors earlier that year. 

First and corresponding author Joseph George told Retraction Watch the error was unintentional. A Columbia spokesperson sent us this statement: Continue reading Columbia University probe prompts retraction of cardiovascular paper

High-profile book on North Korea earns 52 corrections

The author of a high-profile book about the history of North Korea is issuing 52 corrections to the next edition, scheduled to appear this spring. The changes follow heavy criticism of the book, alleging it contained material not supported by the list of references.

Last month, author Charles Armstrong, a professor at Columbia University, announced on his website that he was issuing the changes after reviewing the book in detail, especially the footnotes. He writes:

Continue reading High-profile book on North Korea earns 52 corrections

Nuclear fuel container material isn’t as novel as it appeared in now-retracted paper

A layer of copper sprayed onto steel. (Figure 6 from “Structure and Mechanical Properties of Thick Copper Coating Made by Cold Spray“)

A paper describing the construction of a material that could be used in nuclear fuel containers has been retracted after the authors left out key details.

According to the editor, the omission made the authors’ method seem more novel than it was.

The material is described in “Structure and Mechanical Properties of Thick Copper Coating Made by Cold Spray.” It was published in the January 2016 issue of the Journal of Thermal Spray Technology.

According to the retraction notice, the authors did not specify in the paper how the first layer of copper was sprayed onto the steel:

Continue reading Nuclear fuel container material isn’t as novel as it appeared in now-retracted paper