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How can we improve preclinical research? Advice from a diabetes researcher

Daniel Drucker
Daniel Drucker

By all accounts, science is facing a crisis: Too many preclinical studies aren’t reproducible, leading to wasted time and effort by researchers around the world. Today in Cell Metabolism, Daniel Drucker at the Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital in Toronto details numerous ways to make this early research more robust. His most important advice: more transparent reporting of all results (not just the positive findings), along with quantifying, reporting, tracking, and rewarding reproducibility, for both scientists and journals and universities/research institutes.

Retraction Watch: Which of your recommendations will researchers most object to, and why? Continue reading How can we improve preclinical research? Advice from a diabetes researcher

Meet the filmmakers who cracked open the case against star surgeon Macchiarini

svtlogo-black_v2Paolo Macchiarini — once a world-renowned surgeon for creating tracheas from cadavers and patients’ own stem cells – has been dogged for years by accusations of misconduct. Officials at his institution, Karolinska Institute, initially cleared him of many charges, but that all changed earlier this year, when Swedish Television (SVT) aired a series of documentaries about Macchiarini and his work. The series alleged, in part, that he operated on patients in Russia whose conditions were not life-threatening enough to warrant such a risky procedure. Such serious accusations caused a media storm, and prompted officials to take a second look at Macchiarini’s work. KI dismissed Macchiarini, and many others have resigned, including KI’s vice chancellor. Recently, two new reports critiqued KI’s role in the case, and Sweden’s Central Ethical Review Board found Macchiarini guilty of misconduct in a 2014 paper. We spoke with SVT producers Bosse Lindquist and Johannes Hallbom via email about the fallout from their series.

Retraction Watch: Your documentary series has caused quite a storm: A series of resignations and renewed investigations have followed. Are you surprised by the reaction? Continue reading Meet the filmmakers who cracked open the case against star surgeon Macchiarini

Danish court dismisses charges against neuroscientist in appeal of fraud verdict

court-caseA Copenhagen court has cleared neuroscientist Milena Penkowa of the most serious charges against her after she appealed a 2015 verdict that she had faked data.

According to the CPH Post, the Eastern High Court in Copenhagen dismissed the case. Although the court acknowledged she had committed fraud, it declared it was not “serious forgery.”

On Facebook, Penkowa posted a message (according to the Facebook translation): Continue reading Danish court dismisses charges against neuroscientist in appeal of fraud verdict

Do scientific manuscripts need cover letters?

James Kenar
James Kenar

How important is it to include a cover letter with a manuscript submission?

It seems that opinions differ. A 2013 article in Science Careers asked if it was a “relic;” but in a recent editorial, a journal editor reassures his readers that yes, he reads every cover letter — and yes, it’s important. (If you agree with him, let us know in our poll, below.)

In “Dear Authors: We Do Read Your Cover Letters,” James Kenar, editor of the Journal of the American Oil Chemists’ Society, insists on their importance: Continue reading Do scientific manuscripts need cover letters?

U Colorado revokes PhD of former “golden boy”

university-of-colorado-denver-300x58In a rare move, the University of Colorado has revoked the PhD of a former student in a pharmaceutical research lab, following an investigation that raised concerns about the integrity of his work.

According to The Denver Post, Rajendra Kadam’s degree has been revoked by the University of Colorado Board of Regents.

Last year, an investigation by the University of Colorado Denver into Kadam’s research recommended retracting 10 papers. As we reported at the time, the report flagged eight additional papers co-authored by Kadam whose data could not be validated, raising “concerns as to the scientific validity and integrity” of the material.

Last month, a University of Colorado Denver spokesperson told us Kadam was no longer affiliated with the university; today, Ken McConnellogue, the vice president for communication, confirmed that his degree has now been revoked entirely.

McConnellogue acknowledged that it was a strong move: Continue reading U Colorado revokes PhD of former “golden boy”

Spanish lab admits to image manipulation, retracts one paper, corrects another

JBCA group has retracted one paper and corrected another in the Journal of Biological Chemistry (JBC) for image manipulations.

Last author José G. Castaño told us the manipulation occurred at the Universidad Autónoma de Madrid, where he and one other co-author are based. He declined to name who was responsible.

Here’s the retraction notice for “Cytomegalovirus promoter up-regulation is the major cause of increased protein levels of unstable reporter proteins after treatment of living cells with proteasome inhibitors:”

Continue reading Spanish lab admits to image manipulation, retracts one paper, corrects another

Swiss, French institutions investigating several papers

eth-zurichcnrsInstitutions in France and Switzerland are investigating figures in several molecular biology papers, according to a joint press release published today.

Unfortunately, there’s not much more we can tell you about the investigation — the press release doesn’t specify the names of researchers, journals, or even the area within molecular biology that’s under scrutiny.

The National Center for Scientific Research (CNRS) in France will lead the inquiry, with contribution from ETH Zürich in Switzerland. Molecular biology researchers from both institutions were involved in the flagged publications, an ETH Zürich spokesperson told us.

The ETH Zürich spokesperson added: Continue reading Swiss, French institutions investigating several papers

Authors didn’t generate key brain images, probe finds

Frontiers in Human NeuroscienceA neuroscience journal has issued a retraction after discovering some of the paper’s integral images didn’t originate from the authors’ labs.

The retraction notice  — for a study about a condition once known as “water on the brain” — cites an investigation by the journal’s publisher, Frontiers, which determined that the figures were not “duly attributed.” The authors say they agree with the retraction.  

Here’s the retraction notice for “Revisiting hydrocephalus as a model to study brain resilience,” published by Frontiers in Human Neuroscience: Continue reading Authors didn’t generate key brain images, probe finds

Biologist loses second paper — again, for unvalidated figures

Cellular SignallingA researcher at Case Western Reserve University in Ohio has retracted a second paper after a review found the figures didn’t match the original data.  

Last year, we reported on a previous retraction of a paper co-authored by biologist Alan Levine in Inflammatory Bowel Diseases, which was pulled for the exact same reason; even the retraction notices use similar language. The first author on both papers is Debasmita Mandal, also listed at Case Western Reserve University.

Here’s the retraction notice for “REDOX regulation of IL-13 signaling in intestinal epithelial cells: usage of alternate pathways mediates distinct gene expression patterns,” published by Cellular Signalling: Continue reading Biologist loses second paper — again, for unvalidated figures

Author objects to retraction of heart study, implies industry played role

JACC

The Journal of the American College of Cardiology (JACC) has retracted a recently published paper that questioned the effectiveness of a treatment for irregular heartbeat, against the last author’s wishes. 

Andrea Natale, the study’s last and corresponding author and Executive Medical Director of Texas Cardiac Arrhythmia at Austin, took to social media today to express his frustration in the retraction of the July paper, which showed electrical rotors were less effective at fixing irregular heartbeat than other treatments. On Twitter, Natale implied industry played a role in its demise.

However, according to the retraction notice, the paper was felled by problems with randomization; Natale has admitted that some patients were removed from the analysis after one center included them incorrectly.

Here’s the retraction notice for “Impact of Rotor Ablation in Nonparoxysmal Atrial Fibrillation Patients Results From the Randomized OASIS Trial:” Continue reading Author objects to retraction of heart study, implies industry played role