Category: clinical study retractions

NEJM corrects 3 papers after prominent cancer scientist left off credit for breakthrough

Screen Shot 2016-03-15 at 12.04.43 PMThe New England Journal of Medicine has corrected three highly cited papers to credit researchers who played a role in the work.

The papers describe a treatment in which engineered T cells fight leukemia, originally hailed as a “major advance” in the New York Times. Since the first paper appeared in 2011, co-author Carl June at the University of Pennsylvania has received more than $7 million in grants from the National Institutes of Health, according to MIT Technology Review. But according to a newly published correction, the three NEJM papers failed to note in the acknowledgement section that an important component of the experiments was supplied by researchers at St. Jude Children’s Research Hospital.

The correction, made 11 months after a request from co-author and Penn researcher David Porter, explains the contribution of the St Jude’s researchers:

Continue reading NEJM corrects 3 papers after prominent cancer scientist left off credit for breakthrough

Another paper by GM researcher pulled over manipulation concerns

Screen Shot 2016-03-14 at 11.52.18 AMA researcher who published findings questioning the safety of genetically modified organisms has lost a second paper following concerns of image manipulation.

Last week, the journal animal retracted a 2010 paper by Federico Infascelli, an animal nutrition researcher at the University of Naples, which claimed to find modified genes in the milk and blood of goats who were fed genetically modified soybeans. The retraction stems from an investigation that concluded the authors likely manipulated images, according to the note. Earlier this year, another journal retracted one of Infascelli’s papers that contained a duplicated figure.

In February, Italian paper La Repubblica (which we read with Google Translate) reported that the university found problems in three of his articles and issued a warning.

Here’s the retraction note for “Fate of transgenic DNA and evaluation of metabolic effects in goats fed genetically modified soybean and in their offsprings:”

Continue reading Another paper by GM researcher pulled over manipulation concerns

Journal bans 8 authors for plagiarism

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A medical journal has banned eight authors after discovering that they had published plagiarized work.

We don’t see official author bans as often as we see plagiarism (occasionally, and all the time, respectively). That’s why we’re flagging this case, which is a little old — the International Journal of Medical Science and Public Health announced the ban in March 2015, after it retracted three of the authors’ papers for plagiarism.

All three papers — about recovering from orthopedic problems — have a first author in common: Rajesh Valjibhai Chawda, who was affiliated with the CU Shah Medical College and Hospital in India at the time of the research. (We couldn’t find a webpage for him.)

After an author on one of the original articles alerted the journal of one instance of plagiarism, the journal launched an in-house inquiry, the retraction note explains:

Continue reading Journal bans 8 authors for plagiarism

PLOS ONE retracting paper that cites “the Creator”

Screen Shot 2016-01-19 at 10.50.25 AMPLOS ONE has retracted a paper published one month ago after readers began criticizing it for mentioning “the Creator.”

The article “Biomechanical Characteristics of Hand Coordination in Grasping Activities of Daily Living” now includes a reader comment from PLOS Staff, noting: Continue reading PLOS ONE retracting paper that cites “the Creator”

Surgery studies lacked ethics committee approval

3Surgery Today has pulled a pair of papers that share many authors because the studies they describe were not approved by an institutional ethics committee.

One describes a case in which the researchers removed a mass from a 64-year-old woman’s small intestine; the other describes how the authors removed a growth from a patient’s pancreas. They conclude that the surgery techniques used — like a laparoscopic pancreaticoduodenectomy, a take on the “Whipple Procedure” — can be “feasible, safe, and effective” in certain patients.

The papers share several authors, including a first author, Akihiro Cho, whose affiliation on the papers is Chiba Cancer Center Hospital in Japan. They also share a retraction note, which explains how the journal learned of the issue:

Continue reading Surgery studies lacked ethics committee approval

Top journals give mixed response to learning published trials didn’t proceed as planned

Ben Goldacre
Ben Goldacre

Ben Goldacre has been a busy man. In the last six weeks, the author and medical doctor’s Compare Project has evaluated 67 clinical trials published in the top five medical journals, looking for any “switched outcomes,” meaning the authors didn’t report something they said they would, or included additional outcomes in the published paper, with no explanation for the change. The vast majority – 58 – included such discrepancies. Goldacre talked to us about how journals – New England Journal of Medicine (NEJM), JAMA, The Lancet, BMJ, and Annals of Internal Medicine — have responded to this feedback.

Retraction Watch: When you discover a published trial has switched outcomes, what do you do? Continue reading Top journals give mixed response to learning published trials didn’t proceed as planned

Methodology of paper linking vaccine to behavioral issues “seriously flawed,” says retraction

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After temporarily removing a paper that suggested a link between the vaccine for the human papillomavirus (HPV) and behavioral issues, the journal has now retracted it.

Vaccine says the reason is “serious concerns regarding the scientific soundness of the article,” including flawed methodology and unjustified claims.

Christopher A. Shaw, a co-author on the paper and a researcher at the University of British Columbia, told us he has seen the notice, but doesn’t know the specific issues the journal had with the paper:

We still don’t know why [Editor in Chief] Dr Poland removed the article.

Here’s the retraction notice for “Behavioral abnormalities in young female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil:”

Continue reading Methodology of paper linking vaccine to behavioral issues “seriously flawed,” says retraction

Doctor suspended in UK after faking co-authors, data

Screen Shot 2016-02-24 at 11.04.56 AMA doctor in Manchester, UK has received a year’s suspension by the Medical Practitioners Tribunal Service.

Gemina Doolub admitted that she fabricated research data and submitted papers without the knowledge of her co-authors, including faking an email address for a co-author, a news story in the BMJ reports. The research in question was part of two retractions that Doolub received in 2013, one of which we covered at the time.

Doolub’s research examined ways to treat and avoid microvascular obstruction — that is, blocked arteries. Doolub did the work while at Oxford.

“Intracoronary Adenosine versus Intravenous Adenosine during Primary PCI for ST-Elevation Myocardial Infarction: Which One Offers Better Outcomes in terms of Microvascular Obstruction?” was published in International Scholarly Research Notices Cardiology and has not yet been cited, according to Thomson Reuters Web of Science.

As the BMJ reports, in that paper,

Continue reading Doctor suspended in UK after faking co-authors, data

Psychologist Jens Förster earns second and third retractions as part of settlement

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Jens Förster

High-profile social psychologist Jens Förster has earned two retractions following an investigation by his former workplace. He agreed to the retractions as part of a settlement with the German Society for Psychology (DGPs).

The papers are two of eight that were found to contain “strong statistical evidence for low veracity.” According to the report from an expert panel convened at the request of the board of the University of Amsterdam, following

an extensive statistical analysis, the experts conclude that many of the experiments described in the articles show an exceptionally linear link. This linearity is not only surprising, but often also too good to be true because it is at odds with the random variation within the experiments.

One of those eight papers was retracted in 2014. In November, the American Psychology Association received an appeal to keep two of the papers, and Förster agreed to the retractions of two more:

Continue reading Psychologist Jens Förster earns second and third retractions as part of settlement

“We are living in hell:” Authors retract 2nd paper due to missing raw data

ijcA 2006 paper investigating the effects of docosahexaenoic acid (DHA) and celecoxib on prostate cancer cells has been retracted because it appears to contain panels that were duplicated, and the authors could not provide the raw data to show otherwise.

This is the second paper the authors have lost because they couldn’t furnish the original data to defend their work against allegations of image manipulation. The reason: the Institute for Cancer Prevention in New York, where the authors did the work, shut its doors abruptly in 2004, co-author Bhagavathi A. Narayanan told us. (The institute closed thanks to $5.7 million in grant that was misspent, the New York Post reported at the time.)

Recently, some of Narayanan’s papers have been questioned on PubPeer; her work has been the subject of an investigation at New York University, where Narayanan is now based.

Narayanan told us that the criticism of their work has deeply affected her and her co-authors:

Continue reading “We are living in hell:” Authors retract 2nd paper due to missing raw data