Category: not reproducible

So, pot may not be as harmless as a recent study suggested

adb-150

Researchers are correcting a widely covered study that suggested chronic use of pot might not put users at risk of problems later in life.

It turns out that initial, unexpected finding — covered by Newsweek, The Washington Post, Quartz, and (of course) The Stoner’s Cookbook (now known as HERB) — wasn’t quite right, and a reanalysis found users had a small uptick in risk for psychosis. The authors have issued a lengthy correction in Psychology of Addictive Behaviors that includes some supplemental analysis, too.

Not surprisingly, the study’s findings engendered some controversy, which prompted the authors to reanalyze their data, collected from 408 males with varying levels of marijuana use, who were followed from their teens into their 30s.

Now, an American Psychological Association press release that accompanied the initial findings in August contains an editors note explaining why those aren’t quite correct:

Continue reading So, pot may not be as harmless as a recent study suggested

Here are the 10 — yes, 10 — reasons PLOS ONE retracted this paper

Screen Shot 2016-01-19 at 10.50.25 AMPLOS One is retracting a paper for overlapping with a Wikipedia page. And for containing material lifted from other sources. And for “language errors.” And for insufficient evidence that authors found the pathogens floating around in hospital air that they claimed to find.

The instances of plagiarism are a “huge problem,” each “enough for retraction on its own,” Jonathan Eisen, a microbiologist at the University of California, Davis, told us. Eisen, who posted several comments to the paper after its publication in October, added that the paper was “simply not technically sound.”

The paper — which even contains a spelling error in its title, “Metagenomic Human Repiratory Air in a Hospital Environment” — describes a gene sequencing method to screen the air in hospitals for pathogens. The retraction note lists 10 concerns with the paper: Continue reading Here are the 10 — yes, 10 — reasons PLOS ONE retracted this paper

List of retractions, corrections grows for Duke researchers

cov200hDuke researcher Michael Foster and his former co-author Erin Potts-Kant are adding to their notice count with a major correction from late last year to a paper on how certain cells in mice respond to a pneumonia infection, citing “potential discrepancies in the data.”

The correction is actually a partial retraction: The note explains that parts of three figures should be discounted.

We’ve also recently unearthed multiple corrections and two retractions from the pair that we missed from earlier in 2015.

After questions about the data in the corrected paper arose, the authors were able to replicate most of the experiments in the paper, according to the note. But since the paper was published, the senior author passed away, closing her lab, so they couldn’t repeat all of the work.

Here’s the correction notice for “Mast cell TNF receptors regulate responses to Mycoplasma pneumoniae in surfactant protein A (SP-A)−/− mice,” published in The Journal of Allergy and Clinical Immunology:

Continue reading List of retractions, corrections grows for Duke researchers

Paper on plant immunity can’t fight off manipulation

10.cover

A paper on how plants respond to bacteria has an invader of its own — data manipulation.

The “irregularities and inappropriate data manipulation” were found in a figure produced by the first author, Ching-Wei Chen, whose LinkedIn page lists him as a student at the National Taiwan University. The authors were unable to replicate the results in the figure, according to the note.

The authors are doing more experiments to verify the main conclusion of the 2014 paper, “The Arabidopsis Malectin-Like Leucine-Rich Repeat Receptor-Like Kinase IOS1 Associates with the Pattern Recognition Receptors FLS2 and EFR and Is Critical for Priming of Pattern-Triggered Immunity,” published in The Plant Cell.

The retraction note explains the what happened in more detail:

Continue reading Paper on plant immunity can’t fight off manipulation

Misidentified DNA leads authors to retract zebrafish cholesterol paper

cov150h

Authors are retracting a 2012 paper on cholesterol metabolism in zebrafish after realizing it included a case of mistaken identity in a DNA sequence crucial to some aspects of the experiment.  

A postdoc misidentified the plasmid in question after failing to fully sequence it before including it in the experiment. A technician in the lab found the mistake, last author Steven Farber, a researcher at the Carnegie Institution for Science in Maryland, explained:

When the omitted region was correctly sequenced we discovered it had an error.

He told us in a phone interview what that felt like:

We were like, holy crap.

Next came months of back and forth with the journal, discussing whether to correct or retract the paper. Farber tells us the mistake, which affects two figures,

was unfortunate. Most of the paper is in fact correct.

The paper, “Visualization of Lipid Metabolism in the Zebrafish Intestine Reveals a Relationship between NPC1L1-Mediated Cholesterol Uptake and Dietary Fatty Acid,” published in Chemistry & Biology, has been cited 21 times, according to Thomson Scientific’s Web of Knowledge.

Here’s the detailed retraction note:  Continue reading Misidentified DNA leads authors to retract zebrafish cholesterol paper

Suspicions of data manipulation lead to correction of testicular cancer paper

Screen Shot 2015-12-10 at 5.20.23 PM

The corresponding author of a paper on testicular cancer is telling readers to discount a figure after she learned it may have been manipulated.

Although that one figure in the 2005 paper in the British Journal of Cancer may be problematic, the authors found data to support the other figures, and its conclusions.

This isn’t the first time first author Kerry Manton has faced questions over her data — in 2012, one of her papers was retracted following an investigation by her institution, the Queensland University of Technology. And in 2014, QUT repaid a $275,000 grant after finding Manton

failed to fulfill (her) responsibilities in relation to the responsible dissemination of research findings and that this, coupled with a failure to correct the errors, constituted research misconduct.

Here’s the corrigendum for “Hypermethylation of the 5′ CpG island of the gene encoding the serine protease Testisin promotes its loss in testicular tumorigenesis:”

Continue reading Suspicions of data manipulation lead to correction of testicular cancer paper

A bullshit excuse? My lab notebook “was blown into a manure pit”

CleanA researcher who studies how to turn dairy cattle manure into natural gas falsified and fabricated data in a journal article and failed to declare a commercial conflict of interest, a Washington State University investigation has found.

The study “Evaluation of Co-Digestion at a Commercial Dairy Anaerobic Digester” was published in 2011 in the journal CLEAN: Soil, Air, Water. First author Craig Frear was a Ph.D. student at WSU Pullman when the study was carried out and an assistant professor at the time of the investigation. The editor-in-chief of CLEAN, Prisca Henheik, told us that the retraction is a done deal even though it has not been posted online: Continue reading A bullshit excuse? My lab notebook “was blown into a manure pit”

Paper pulled when authors backtrack on identifying mad cow disease in Texas

Journal food protectionA journal is pulling a paper that reported a grain sample in Texas tested positive for mad cow disease after the authors asked to change the results to say the sample contained “animal protein prohibited for use in ruminant feed.”

Shortly after the paper was published in October, the authors contacted the Journal of Food Protection to retract the finding that the grain sample tested positive for bovine spongiform encephalopathy (BSE). After review, the journal decided to retract the entire paper, with the authors’ agreement, citing changes that “significantly affect” the findings.

JFP scientific editor Lauren Jackson filled us in on some details: Continue reading Paper pulled when authors backtrack on identifying mad cow disease in Texas

Authors retract antioxidant paper after more work reverses their conclusion

Screen Shot 2015-12-03 at 12.29.58 PM

The authors of a paper about the benefits of an antioxidant found in blueberries known as pterostilbene have retracted it after their subsequent research suggested the antioxidant might actually be harmful.

The paper presented evidence that the antioxidant might help rats after heart attack, in part by inhibiting cell death (apoptosis). But according to the retraction note, more work

found that pterostilbene might induce apoptosis in the heart and can be harmful, and we are now focusing on the phenomenon.

The rest of the retraction note for “Pterostilbene attenuates inflammation in rat heart subjected to ischemia-reperfusion: role of TLR4/NF-κB signaling pathway,” published in the International Journal of Clinical and Experimental Medicine, suggests that the authors would consider republishing their findings if they became more confident in the data:

Continue reading Authors retract antioxidant paper after more work reverses their conclusion

Science retracts physics paper after magnetic field wasn’t what it seemed

F1.mediumScience has retracted an August paper on an interesting electric current researchers observed in a kind of material called a topological insulator. Well, a current the researchers — based at Stanford and MIT — thought they had observed.

A magnetic field with particular attributes reported in the paper seemed to provide evidence of the current. But the researchers soon discovered that the field might have been, in part, an artifact of the very device they used to detect it. The authors, along with a few other researchers, have published that subsequent finding on the physics preprint server, arXiv.

Here’s the retraction note:
Continue reading Science retracts physics paper after magnetic field wasn’t what it seemed