Category: data issues

Family squabble over safety of eye therapy forces journal to pull paper

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A father and son are fighting over whether a laser therapy they describe as co-authors of a 2015 paper could be harmful to patients, prompting the journal to retract the article.

The small study suggested that the therapy could safely treat patients with glaucoma. But Tomislav Ivandic — the father — alleges that errors in how the study was reported could lead to harmful doses of laser light for patients receiving the therapy. His son and co-author, Boris Ivandic, maintains that the article is accurate.

To err on the side of patient safety, Photomedicine and Laser Surgery retracted “Effects of Photobiomodulation Therapy on Patients with Primary Open Angle Glaucoma: A Pilot Study.”

The retraction note explains the dispute:

Continue reading Family squabble over safety of eye therapy forces journal to pull paper

Sperm paper impaired by “corporate company” analysis

2.coverWithout a certain protein, mouse sperm have motility disorders. That’s the conclusion of a paper that has itself been stopped — by errors in the data analysis, carried out by a third-party company.

The retraction note pins the analysis, which led to faulty data, on a “corporate company.” Aside from the companies that sell the kits used for substrates, assays, and detection, there’s only one company mentioned in the paper:

Generation of the mouse model was performed by the Cyagen Company (Guangzhou, China)

However, a representative of Cyagen says it does not offer the type of analysis described by the retraction note.

Here’s the full retraction note for the 2015 paper in Biology of Reproduction (which is paywalled — tsk, tsk):
Continue reading Sperm paper impaired by “corporate company” analysis

Entire paper about cell division plagiarized

Chinese med jA paper about the role of specific proteins in the separation of newly replicated chromosomes is being retracted from the Chinese Medical Journal, after editors found out that the entire article was plagiarized.

The study, “MreBCD Associated Cytoskeleton is Required for Proper Segregation of the Chromosomal Terminus during the Division Cycle of Escherichia Coli,” names Feng Lu as the corresponding author and claims that the work was done in his lab at the Medical School of Henan University in Henan, China. The misappropriation came to light when a member of Lawrence Rothfield’s lab at the University of Connecticut saw the paper after it was published online last April, and realized that it was an exact replica of an unpublished paper that Rothfield’s own lab had produced.

Here’s the retraction note from the journal: Continue reading Entire paper about cell division plagiarized

Upon discovering several errors, authors retract gastric cancer paper

mmr_12_4After finding several errors in their paper about the molecular activity underlying gastric cancer, the authors unanimously decided to retract it.

According to the retraction note, three figures in the paper had β‑actin bands that were omitted, interchanged, or both.

The retraction note provides the details:

Continue reading Upon discovering several errors, authors retract gastric cancer paper

STAP stem cell researcher Obokata loses another paper

Nature protocols

The first author of two high-profile Nature retractions about a technique to easily create stem cells has lost another paper in Nature Protocols.

Haruko Obokata, once “a lab director’s dream,” according to The New Yorker, also had her PhD revoked from Waseda University last fall.

After learning of concerns that two figures are “very similar” and “some of the error bars look unevenly positioned,” the rest of the authors were unable to locate the raw data, according to the note. The journal could not reach Obokata for comment before publishing the retraction.

“Reproducible subcutaneous transplantation of cell sheets into recipient mice” has been cited 21 times, according to Thomson Reuters Web of Science. It was published in June 2011, soon after Obokata earned her PhD. 

Here’s the note:

Continue reading STAP stem cell researcher Obokata loses another paper

Doctor suspended in UK after faking co-authors, data

Screen Shot 2016-02-24 at 11.04.56 AMA doctor in Manchester, UK has received a year’s suspension by the Medical Practitioners Tribunal Service.

Gemina Doolub admitted that she fabricated research data and submitted papers without the knowledge of her co-authors, including faking an email address for a co-author, a news story in the BMJ reports. The research in question was part of two retractions that Doolub received in 2013, one of which we covered at the time.

Doolub’s research examined ways to treat and avoid microvascular obstruction — that is, blocked arteries. Doolub did the work while at Oxford.

“Intracoronary Adenosine versus Intravenous Adenosine during Primary PCI for ST-Elevation Myocardial Infarction: Which One Offers Better Outcomes in terms of Microvascular Obstruction?” was published in International Scholarly Research Notices Cardiology and has not yet been cited, according to Thomson Reuters Web of Science.

As the BMJ reports, in that paper,

Continue reading Doctor suspended in UK after faking co-authors, data

“We are living in hell:” Authors retract 2nd paper due to missing raw data

ijcA 2006 paper investigating the effects of docosahexaenoic acid (DHA) and celecoxib on prostate cancer cells has been retracted because it appears to contain panels that were duplicated, and the authors could not provide the raw data to show otherwise.

This is the second paper the authors have lost because they couldn’t furnish the original data to defend their work against allegations of image manipulation. The reason: the Institute for Cancer Prevention in New York, where the authors did the work, shut its doors abruptly in 2004, co-author Bhagavathi A. Narayanan told us. (The institute closed thanks to $5.7 million in grant that was misspent, the New York Post reported at the time.)

Recently, some of Narayanan’s papers have been questioned on PubPeer; her work has been the subject of an investigation at New York University, where Narayanan is now based.

Narayanan told us that the criticism of their work has deeply affected her and her co-authors:

Continue reading “We are living in hell:” Authors retract 2nd paper due to missing raw data

Journal retracts 7 papers by MD Anderson cancer researcher long under investigation

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Bharat Aggarwal

An MD Anderson Cancer Center researcher who has been under investigation by the institution for at least several years has had seven papers retracted from a single journal.

Bharat Aggarwal told us in 2012 that MD Anderson was investigating his work, but in 2013 threatened to sue us for reporting on the case. Aggarwal is no longer listed in the MD Anderson directory, and an email to him there bounced.

This week, Biochemical Pharmacology retracted seven studies of which he is the only common author, noting the “data integrity has become questionable.” The papers have been cited a total of more than 500 times, according to Thomson Scientific’s Web of Knowledge; one has been designated as “highly cited.” Here are the seven retractions: Continue reading Journal retracts 7 papers by MD Anderson cancer researcher long under investigation

Should there be “data authors?” Q&A with NEJM editor Jeffrey Drazen

Jeffrey Drazen ©2011 Jon Chomitz Photography 3 Prescott street, Somerville, MA 02143 www.chomitz.com jon@chomitz.com 617.625.6789
Jeffrey Drazen ©2011 Jon Chomitz Photography

Would designating a set of authors as responsible for data production – separate from those who conduct the analysis – help boost the reliability of papers? That’s a question raised by the editor of the New England Journal of Medicine, Jeffrey Drazen. Along with many other editors of top medical journals, Drazen recently signed a proposal by the International Committee of Medical Journal Editors to require authors of clinical trials to share anonymous patient data within six months of publication. He talked to us about another way to make trials more robust: Create “data authors.”

Retraction Watch: What has been the reaction so far to ICMJE’s data sharing proposal? Continue reading Should there be “data authors?” Q&A with NEJM editor Jeffrey Drazen

Authors used wrong dataset in study on shock therapy, exercise in depression

J psych resA psychiatric journal has pulled a 2014 paper that found electroconvulsive therapy and exercise helped people with depression, after the authors determined they had mistakenly analyzed the wrong data.

According to the retraction notice from the Journal of Psychiatric Research, the researchers had “erroneously analyzed” data from a previous study they had published the year before.

Here’s more from the note for “Electroconvulsive therapy and aerobic exercise training increased BDNF and ameliorated depressive symptoms in patients suffering from treatment-resistant major depressive disorder:” Continue reading Authors used wrong dataset in study on shock therapy, exercise in depression