Category: clinical study retractions

Does dose matter? Tumor killer paper thought so, now must retract

Molecular Medicine ReportsAfter questions from a reader, researchers took a second look at their data about the effects of a vitamin A metabolite on tumor cells, and realized their key finding was inaccurate.

They’re now retracting the paper, from Molecular Medicine Reports, because it originally reported that higher concentrations of retinoic acid (RA) were more effective in curbing the proliferation of brain tumor cells. But it seems that the RA dose made less of a difference than they originally believed, according to the retraction notice:

Continue reading Does dose matter? Tumor killer paper thought so, now must retract

UK tribunal orders release of data from controversial chronic fatigue syndrome study

court caseA tribunal in the UK has rejected an appeal by Queen Mary University of London, who sought to reverse a previous order that they release data from a controversial 2011 paper in The Lancet about chronic fatigue syndrome (CFS).

The decision is one in a long series of judgments about the so-called PACE trial, which reported that two treatments — known as cognitive behavioral therapy and graded exercise therapy — helped alleviate the symptoms of the condition. But ever since The Lancet article and follow-up papers have been published, patients and critics have questioned the conclusions and clamored to see the raw data.

The main criticisms: The findings may prompt some to believe chronic fatigue is a mental, not a physical, disorder, and the PACE program could actually be harmful to patients by encouraging too much exercise. These criticisms were recently bolstered by a re-analysis of the evidence by the Agency for Healthcare Research and Quality, which downgraded its original conclusions about the effectiveness of cognitive behavioral therapy and graded exercise therapy.

In March 2014,  Continue reading UK tribunal orders release of data from controversial chronic fatigue syndrome study

Journal blacklists authors for plagiarizing case report about hypersexuality in dementia

Advances in Human BiologyA biology journal has blacklisted authors from publishing their work after finding their case report about a dementia patient with hypersexuality was plagiarized from a previously published report.

The retraction notice, issued by Advances in Human Biology (AIHB) in June, recognizes the case as “scientific misconduct.” The journal launched an investigation after the plagiarism was flagged by the author of the original report, the editor-in-chief of the journal told us. Eventually, the journal retracted the report — and removed it entirely from their website.

Additionally, the journal posted this notice on their site, blacklisting the authors from publishing in AIHB again: Continue reading Journal blacklists authors for plagiarizing case report about hypersexuality in dementia

Judges toss lawsuits by CrossFit gym claiming fraud in $273 million in grants

court caseFederal judges in Ohio have dismissed two lawsuits claiming that university researchers used false results to secure more than $250 million in federal grants.

Both lawsuits, which objected to a study examining the effects of CrossFit-based training, were filed by Mitchell Potterf, the owner of a gym affiliated with CrossFit in Columbus, Ohio. Potterf took issue with a 2013 study by researchers at Ohio State University (OSU) that was conducted at his gym.

Potterf filed one suit against the OSU researchers and a second against the National Strength and Conditioning Association (NCSA). The NSCA publishes the Journal of Strength and Conditioning Research, where a paper about the study appeared. The article, “Crossfit-based high-intensity power training improves maximal aerobic fitness and body composition,” has been cited 15 times, according to Thomson Reuters Web of Science.

The study followed 43 men and women as they completed 10 weeks of CrossFit-based training. In addition to those 43 participants, 11 dropped out before completing the regimen. According to the original paper: Continue reading Judges toss lawsuits by CrossFit gym claiming fraud in $273 million in grants

Author loses five papers, most for “compromised” peer review

PLOS OnePLOS ONE has retracted three papers after the first author admitted to submitting the manuscripts without co-authors’ consent, and an investigation suggested that two out of the three papers had received faked reviews.

Last August, the same author — Lishan Wang of the Shanghai Jiao Tong University — lost two more papers (one in Tumor Biology and the other in Gene), also after the peer review process was found to be compromised. All five papers — which share other authors in common — were originally published in 2013, and four list Wang as the first author. The retractions follow an investigation by Shanghai Jiao Tong University.

Here’s the retraction notice for two of the PLOS ONE papers, issued on July 26: Continue reading Author loses five papers, most for “compromised” peer review

Second retraction for bone researcher with lifetime funding ban

via WCH
via WCH

A researcher banned from funding by a Canadian agency for misconduct has earned her second retraction, after a reanalysis uncovered problems with the paper’s conclusions.

The retraction follows an investigation by Sophie Jamal‘s former workplace, the Women’s College Hospital in Toronto, which has led to a recent retraction of a JAMA paper due to data manipulation, and a lifetime funding ban from the Canadian Institutes of Health Research (CIHR).

The latest retraction stemmed from a re-analysis of the paper by the Canadian Multicentre Osteoporosis Study Group, of which the paper was a part; all authors but Jamal have requested the retraction. In the notice, the authors say that they believe no patients were harmed as a result of the “possibly invalid conclusions” in the paper, which showed patients with kidney problems were at higher risk of bone loss. A researcher told us a third paper by Jamal is also due to be retracted soon.

Here’s the retraction notice, issued by the American Journal of Kidney Diseases (AJKD): Continue reading Second retraction for bone researcher with lifetime funding ban

Journal flags two papers by prominent diabetes researcher, more questioned on PubPeer

DiabetesDiabetes has issued two expressions of concern (EOCs) for papers co-authored by leading diabetes researcher Kathrin Maedler, adding to her previous count of one retraction and three corrections.

Both papers were questioned on PubPeer, alongside several others co-authored by Maedler, who is based at the University of Bremen in Germany. As we previously reported, PubPeer comments have led to one retraction for Maedler in the Journal of Biological Chemistry (JBC), and corrections in various other journals.

One of those corrections has now earned an EOC from Diabetes, which also extends to the original paper. Here are the notices, which asks the University of Bremen to investigate further:  Continue reading Journal flags two papers by prominent diabetes researcher, more questioned on PubPeer

You’ve been dupe’d: Results so nice, journals published them twice

With so many retraction notices pouring in, from time to time we compile a handful of straight-forward retractions.

Once again, this list focuses on duplications — but unlike other duplications, these authors were not at fault. Rather, these retractions occurred because the publishers mistakenly published the same paper twice — the result of a transfer between publishers, for instance, or accidentally publishing the unedited version of the paper. We’re forced to wonder, as we have before, whether saddling researchers’ CVs with a retraction is really the most fair way to handle these cases.

So without further ado, here’s five cases where the journal mistakenly duplicated a paper, and had to retract one version: Continue reading You’ve been dupe’d: Results so nice, journals published them twice

Seven retractions for prominent cancer researcher brings total to 18

Bharat Aggarwal
Bharat Aggarwal

A cancer researcher has earned seven more retractions following an investigation into his work by his former employer, MD Anderson Cancer Center in Texas, bringing his total to 18 retractions.

Bharat Aggarwal‘s name will be familiar to some readers, as he has threatened to sue Retraction Watch for reporting on his case.

All of the new retraction notices, issued by The Journal of Biological Chemistry (JBC), stem from image-related issues. The now-retired Aggarwal has seven papers that have each been cited at least 1,000 times, and in 2015, he was on Thomson Reuters Web of Science’s list of The World’s Most Influential Scientific Minds. With these new notices, he also has made it to our leaderboard of individual researchers who’ve racked up the most retractions.

An MD Anderson spokesperson sent us this statement: Continue reading Seven retractions for prominent cancer researcher brings total to 18

UK doctor banned from practice after fabricating data in grant applications

Queen Mary University of LondonA prominent cancer researcher in England has been banned from practicing medicine and has lost his funding from a UK charity after being found to have fabricated data in grant applications.

The moves against the researcher, Thorsten Hagemann, come after investigations by the General Medical Council, akin to a U.S. state medical board, and Hagemann’s former institution, Queen Mary University of London (QMUL), turned up evidence of misconduct. In June, we reported on the retraction of a meeting abstract in The Journal of Pathology and the corrigendum of a Nature paper by Hagemann following the inquiry at QMUL.

A spokesperson from the Medical Practitioners Tribunal Service told the Evening Standard: Continue reading UK doctor banned from practice after fabricating data in grant applications