basic life sciences retractions – Page 46

“We are living in hell:” Authors retract 2nd paper due to missing raw data

A 2006 paper investigating the effects of docosahexaenoic acid (DHA) and celecoxib on prostate cancer cells has been retracted because it appears to contain panels that were duplicated, and the authors could not provide the raw data to show otherwise.

This is the second paper the authors have lost because they couldn’t furnish the original data to defend their work against allegations of image manipulation. The reason: the Institute for Cancer Prevention in New York, where the authors did the work, shut its doors abruptly in 2004, co-author Bhagavathi A. Narayanan told us. (The institute closed thanks to $5.7 million in grant that was misspent, the New York Post reported at the time.)

Recently, some of Narayanan’s papers have been questioned on PubPeer; her work has been the subject of an investigation at New York University, where Narayanan is now based.

Narayanan told us that the criticism of their work has deeply affected her and her co-authors:

Continue reading “We are living in hell:” Authors retract 2nd paper due to missing raw data

Firefly paper flagged following Queensland investigation

A BMC journal has added an expression of concern to a paper on firefly genes after a University of Queensland investigation determined a table should be credited to a different source.

According to a representative of the university, the investigation found no evidence of misconduct. The university submitted an erratum that the journal chose not to publish; in the EOC note, the journal says the wording of the erratum is “under dispute.”

The erratum submitted to the journal specifies that the table should be attributed to former UQ biologist Robert Birch, who was not an author on the paper. The investigation concluded that the authors had not committed misconduct and “acted in good faith” in using the table, Anton Middelberg, University of Queensland Pro-Vice-Chancellor told us.

The paper, “Synthetic versions of firefly luciferase and Renilla luciferase reporter genes that resist transgene silencing in sugarcane, published in BMC Plant Biology, has been cited twice, according to Thomson Scientific’s Web of Knowledge.

Here’s the expression of concern:

Continue reading Firefly paper flagged following Queensland investigation

Journal retracts 7 papers by MD Anderson cancer researcher long under investigation

An MD Anderson Cancer Center researcher who has been under investigation by the institution for at least several years has had seven papers retracted from a single journal.

Bharat Aggarwal told us in 2012 that MD Anderson was investigating his work, but in 2013 threatened to sue us for reporting on the case. Aggarwal is no longer listed in the MD Anderson directory, and an email to him there bounced.

This week, Biochemical Pharmacology retracted seven studies of which he is the only common author, noting the “data integrity has become questionable.” The papers have been cited a total of more than 500 times, according to Thomson Scientific’s Web of Knowledge; one has been designated as “highly cited.” Here are the seven retractions: Continue reading Journal retracts 7 papers by MD Anderson cancer researcher long under investigation

2001 sepsis paper “deviates from the ethical standard of authorship,” says journal

We don’t have a lot of information on a recent retraction of a 2001 paper published in a Japanese journal — just a brief and strongly worded note explaining that it follows “a strict, extensive, and judicious review.”

The paper, retracted 14 years after it was published, describes patients in Okinawa, Japan who developed severe symptoms following infection by bacteria belonging to the Aeromonas genus. One example:

The one patient was a 15-year-old high school girl student, who had been healthy in her school life, was admitted to the hospital with a sudden onset of left thigh muscle pain and swelling. She subsequently went into septic shock and died one day after admission. Pathological examination on autopsy revealed massive gas formation, skin bullas and ulcers, and extensive severe soft tissue damage throughout the body.

“Aeromonas species infection with severe clinical manifestation in Okinawa, Japan-association with gas gangrene” has been cited three times, according to Thomson Scientific’s Web of Knowledge. It was published in a Japanese journal, Rinsho Biseibutshu Jinsoku Shindan Kenkyukai Shi — which translates to the Journal of the Association for Rapid Method and Automation in Microbiology.

The retraction note suggests that there are major flaws: Continue reading 2001 sepsis paper “deviates from the ethical standard of authorship,” says journal

Sanction for Toronto researchers upheld despite court challenge

A Toronto hospital network is keeping two researchers’ labs closed even after an Ontario court quashed part of a misconduct finding by the institution.

Some background: After the University Health Network found evidence of falsified data, Sylvia Asa stepped down as Program Medical Director of the Laboratory Medicine Program, the largest hospital diagnostic laboratory in Canada. Due to the investigation, UHN suspended the labs of Asa and her husband Shereen Ezzat. In response, Asa and Ezzat asked an Ontario court to quash the misconduct findings; last month, the court overturned two out of three findings, and asked UHN to reconsider its sanction against the pair.

According to the Toronto Star, on February 4th the UHN notified the researchers that the sanction against them would be upheld, and it would not reopen the researchers’ labs.

The Star spoke to the researcher’s lawyer, Brian Moher who Continue reading Sanction for Toronto researchers upheld despite court challenge

Why publishing negative findings is hard

When a researcher encountered two papers that suggested moonlight has biological effects — on both plants and humans — he took a second look at the data, and came to different conclusions. That was the easy part — getting the word out about his negative findings, however, was much more difficult.

When Jean-Luc Margot, a professor in the departments of Earth, Planetary & Space Sciences and Physics & Astronomy at the University of California, Los Angeles, tried to submit his reanalysis to the journals that published the original papers, both rejected it; after multiple attempts, his work ended up in different publications.

Disagreements are common but crucial in science; like they say, friction makes fire. Journals are inherently disinterested in negative findings — but should it take more than a year, in one instance, to publish an alternative interpretation to somewhat speculative findings that, at first glance, seem difficult to believe? Especially when they contain such obvious methodological issues such as presenting only a handful of data points linking biological activity to the full moon, or ignore significant confounders?

Margot did not expect to have such a difficult experience with the journals — including Biology Letters, which published the study suggesting that a plant relied on the full moon to survive: Continue reading Why publishing negative findings is hard

Court dismisses lawsuit by XMRV-chronic fatigue syndrome researcher

A California court has dismissed virologist Judy Mikovits’s lawsuit against fourteen people and two Nevada corporations, in part because she failed to submit necessary documents on time.

Mikovits is the author on a now-retracted Science paper suggesting a link between a virus known as XMRV and chronic fatigue syndrome, which has no known cause. She alleged that she was fired from the Whittemore-Peterson Institute for blowing the whistle on her former colleague’s activities, and that the defendants then colluded to imprison and defame her.

The court dismissed her case last Wednesday. According to the court minutes,

Continue reading Court dismisses lawsuit by XMRV-chronic fatigue syndrome researcher

Seralini paper released by predatory publisher is plagiarized by predatory journal

A 2012 paper co-authored by Gilles Seralini, who has published controversial research showing the dangers of genetically modified foods, has been plagiarized by another researcher.

The 2016 paper, published in the International Journal of Technical Research and Applications, has not been retracted, but the text comparison is fairly obvious.

It’s a case of intra-predatory crime: the International Journal of Technical Research and Applications is on the list of predatory journals compiled by Jeffrey Beall, and the Seralini paper appeared in the Journal of Environmental Protection, which is published by Scientific Research Publishing, which Beall considers to be a predatory publisher.

Here’s the abstract from Seralini’s 2012 paper, “Glyphosate Exposure in a Farmer’s Family:” Continue reading Seralini paper released by predatory publisher is plagiarized by predatory journal

Journals retracts three bone papers for duplication by same author

~~A journal is~~ Journals are retracting three papers after a biomaterials researcher duplicated his own work, sometimes using the same figures to describe different experiments.

Two of the papers are on bone regeneration; one is about targeting tumors. In addition to issues with figures, ~~two~~ one of the retraction notes explain that the papers contain “widespread plagiarism of text” from other papers by the researcher, Hossein Hosseinkhani.

Hosseinkhani is currently affiliated with the National Taiwan University of Science and Technology; when he did the work in the now retracted papers, published in 2004 and 2007, he was based at Kyoto University Hospital and then National Institute for Materials Science in Japan.

The Journal of Controlled Release published ~~all three~~ two of the papers. Here’s the retraction note for “Bone regeneration through controlled release of bone morphogenetic protein-2 from 3-D tissue engineered nano-scaffold,” which has been cited 118 times, according to Thomson Scientific’s Web of Knowledge.

Continue reading Journals retracts three bone papers for duplication by same author

Journal retracts nanoparticles paper for duplicating figures

A paper on nanoparticles that target cancer cells has been retracted for duplicating figures from three other papers.

The articles all share a first author: Manasmita Das, based at the time of the research at the Indian Institute of Technology Kharagpur and the National Institute of Pharmaceutical Education and Research (NIPER). According to her LinkedIn profile, she is currently a postdoc at the University of North Carolina.

The abstract of the 2011 Bioconjugate Chemistry paper explains just what the new nanoparticles would be useful for:

Multifunctional nanoparticles, developed in the course of the study, could selectively target and induce apoptosis to folate-receptor (FR) overexpressing cancer cells with enhanced efficacy as compared to the free drug. In addition, the dual optical and magnetic properties of the synthesized nanoparticles aided in the real-time tracking of their intracellular pathways also as apoptotic events through dual fluorescence and MR-based imaging.

But according to the retraction note, figure duplications “seriously undermine the conclusions presented in the research article.” Here’s more about the source of those duplications from the full note: Continue reading Journal retracts nanoparticles paper for duplicating figures

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