Category: basic life sciences retractions

Controversial gene-editing study flagged by Nature journal

nature-biotechnologyNature Biotechnology has issued an editorial expression of concern (EOC) for a widely criticized study describing a potentially invaluable new lab tool.

The EOC mentions the lack of reproducibility of the gene-editing technique, known as NgAgo. Alongside it, the journal has published a correspondence which includes data from three separate research groups that cast doubt on the original findings.

According to a spokesperson for the journal, some of the paper’s authors have objected to the decision to issue an EOC.

Earlier this month, we reported on a letter signed by 20 researchers which also raised concerns about the genome-editing activities of NgAgo — and alleged the lab that produced the initial results turned away investigators when they attempted to validate the tool in mammalian cells.

Here’s the EOC, published yesterday: Continue reading Controversial gene-editing study flagged by Nature journal

Study linking vaccines to autism pulled following heavy criticism

Frontiers in Public HealthA study linking vaccines to autism and other neurological problems has been removed by a Frontiers journal after receiving heavy criticism since it was accepted last week. 

The abstract — published online in Frontiers in Public Health after being accepted November 21 — reported findings from anonymous online questionnaires completed by 415 mothers of home-schooled children 6-12 years old. Nearly 40 percent of children had not been vaccinated, and those that had were three times more likely to be diagnosed with neurodevelopmental disorders such as autism, the study found.

After receiving criticism on Twitter, Frontiers released a public statement, noting that the study was only “provisionally accepted but not published,” and is being re-reviewed. When asked for a comment, a Frontiers spokesperson referred us to the statement. Continue reading Study linking vaccines to autism pulled following heavy criticism

A grad student was caught in the crossfire of fraud — and fought back

uqIn March, 2013, a graduate student joined the lab of a prominent researcher in Australia, investigating new therapies for Parkinson’s. A few months later, everything fell apart.

In September 2013, the University of Queensland (UQ) announced it was retracting one of the lab’s papers, returning the money used to fund the research and launching a fraud investigation.  Since then, the scandal has grown to the point where the lead researcher and his co-author have been convicted of fraud in an Australian court.  

Now, the graduate student is fighting back. After losing her research project and being escorted off campus for allegedly erratic behavior, she has appealed to UQ to reimburse her for tens of thousands of dollars in tuition, and is now awaiting a verdict from a government ombudsman. The graduate student goes by “Dominique,” which is not her real name; Retraction Watch is keeping her identity confidential to protect her privacy. Continue reading A grad student was caught in the crossfire of fraud — and fought back

Nature Cell Biology retracts hotly debated cancer paper

ncbLast week, we learned a 2016 paper heavily discussed on PubPeer might be retracted — today, we learned that Nature Cell Biology has indeed pulled the paper, citing inappropriate image modifications.

As we reported last week, a comment on PubPeer flagged as coming from an author said they had requested a retraction. A representative of National Taiwan University (NTU) told us the first author had resigned, and the paper was under investigation — an investigation which included the last author, a prominent researcher who is also a vice president at another institution in Taiwan.

Here’s Nature Cell Biology‘s official statement about the paper, in the form of a retraction notice that appears to be written by the authors:  Continue reading Nature Cell Biology retracts hotly debated cancer paper

More questions arise over gene-editing tool

13238A new letter signed by 20 researchers is casting additional doubts on the validity of a potentially invaluable lab tool — and alleges the lab that produced the initial results turned them away when they tried to replicate its findings in mammalian cells.

In a letter published this week in Protein & Cell, the researchers add their voices to the critics of the gene-editing technique, first described earlier this year in Nature Biotechnology.

The researchers outline their attempts to apply the technique — known as NgAgo — to a variety of cell types, which fell short:

Continue reading More questions arise over gene-editing tool

Nature Cell Bio paper may be headed for retraction

ncbA Nature Cell Biology paper published only a few months ago by prominent researchers in Taiwan has sparked a heated discussion on PubPeer, which now includes a comment allegedly from an author saying they have requested its retraction.

Although a representative of the journal wouldn’t confirm to us that the authors had requested a retraction, the comment on PubPeer says the paper contains several figures that were “inappropriately manipulated” by the first author.

Here’s the full comment on PubPeer, tagged as coming from one of the authors of the paper:

Continue reading Nature Cell Bio paper may be headed for retraction

Two Harvard-led groups pull well-cited cancer papers for duplication

the-journal-of-clinical-investigationTwo sets of authors based largely at Harvard Medical School have each retracted a paper for duplication in the same journal.

Both papers — which are more than a decade old — were pulled in The Journal of Clinical Investigation on November 1 by their respective corresponding authors.

One paper’s last author told us it was difficult to identify how the duplications occurred since the study took place so long ago, but added that multiple experiments had corroborated the results.

Here’s the first retraction notice for “Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism:” Continue reading Two Harvard-led groups pull well-cited cancer papers for duplication

Genetics study flagged for reliability issues by Frontiers journal

frontiers-in-geneticsA genetics journal has issued an expression of concern (EOC) for a study after an investigation by its chief editors.

According to the notice in Frontiers in Genetics, the authors of the paper — based at Hokkaido University in Sapporo, Japan — are conducting further experiments to resolve the issues raised by the journal’s investigation.

In February, the same paper received a corrigendum due to errors in the assembly of one of the figures.

Here’s the EOC, issued earlier this week: Continue reading Genetics study flagged for reliability issues by Frontiers journal

Family decries publication of child’s picture in open access journal

indian-journal-of-dermatology-venereology-and-leprologyAn author of a paper about a boy with a rare genetic disorder has retracted it after the patient’s family revoked permission to use his photo.

The 2012 paper in the Indian Journal of Dermatology, Venereology and Leprology (IJDVL) told the tale of a 14-year old boy with Delleman syndrome, a condition that often results in the development of cysts within the cavities of the skull, leading to malformations in the eyes, brain, and skin.

Mabel Nocito, the study’s first and corresponding author from Hospital Churruca in Buenos Aires, Argentina told us the parents initially gave permission to publish their son’s picture, but then became concerned when they realized the paper was freely accessible: Continue reading Family decries publication of child’s picture in open access journal

Journal pulls plug on paper that predicts person’s death, against authors’ objections

frontier-in-human-neuroscienceSome people can look at an old photograph of a person — say, of your grandmother in elementary school — and tell whether the person is today alive or dead, according to a paper published last spring.

If that sounds too weird to be true…well, it might be. The journal editors have retracted the paper for not having enough evidence to back up its claims, despite the authors’ objections.

Here’s the retraction notice for “Prediction of Mortality Based on Facial Characteristics,” published in Frontiers in Human Neuroscience:

Continue reading Journal pulls plug on paper that predicts person’s death, against authors’ objections