Category: investigator error

Paper reports data from PET/CT scan, years before it arrived

MedicineAuthors have retracted a study just three months after publishing it, upon realizing they made “several critical errors.”

For one, the authors didn’t actually collect the data they claim to in the title of the paper, which reported on methods to screen patients for recurrence of lung cancer. The authors included data from positron emission tomography/computed tomography (PET/CT), collected from 2003 to 2007 — but their institution didn’t have a PET/CT scanner until 2009. Instead, the authors had mistakenly reported the results of PET scans alone, which may not find tumors as effectively as PET/CT.

Here’s the retraction notice in Medicine, which explains the nature of the error in more detail. (Note: One of the authors supplied some missing text, in brackets.)

Continue reading Paper reports data from PET/CT scan, years before it arrived

Epilepsy researcher gets retraction, correction after former colleague flags work

EpilipsiaEpilepsy researcher Toni Schneider has received a retraction and a correction in quick succession, after a former colleague raised red flags about the work. 

The retraction for Schneider, based at the University of Köln in Germany, is for “unintentional inclusion of erroneous data” due to limitations of the recording system used in the paper, according to the notice. 

Marco Weiergräber, a former colleague of Schneider’s, has claimed that the authors of the paper did not use the test properly. The journal editor, however, told us he believes the original analysis is an “honest mistake,” and there is “no evidence” to suggest that the authors intentionally published incorrect analyses.

Here’s the retraction notice, issued by the journal in March 2016: Continue reading Epilepsy researcher gets retraction, correction after former colleague flags work

Researcher who sued to stop retractions gets his sixth

Mario Saad
Mario Saad

A sixth retraction has appeared for a diabetes researcher who previously sued a publisher to try to stop his papers from being retracted.

Mario Saad‘s latest retraction, in PLOS Biology, stems from inadvertent duplications, according to the authors.  Though an investigation at Saad’s institution — the University of Campinas in Brazil — found no evidence of misconduct, a critic of the paper told The Scientist he does not believe that the issues with blots were inadvertent.

Previously, Saad sued the American Diabetes Association to remove four expressions of concern from his papers; they were later retracted, even though Unicamp recommended keeping three of them published.

Here’s the new retraction notice, for “Gut Microbiota Is a Key Modulator of Insulin Resistance in TLR 2 Knockout Mice:” Continue reading Researcher who sued to stop retractions gets his sixth

Structural biology corrections highlight best of the scientific process

Nature_latest-coverIf you need evidence of the value of transparency in science, check out a pair of recent corrections in the structural biology literature.

This past August, researchers led by Qiu-Xing Jiang at the University of Texas Southwestern Medical Center corrected their study, first published in February 2014 in eLife, of prion-like protein aggregates called MAVS filaments, to which they had ascribed the incorrect “helical symmetry.” In March, Richard Blumberg of Harvard Medical School, and colleagues corrected their 2014 Nature study of a protein complex called CEACAM1/TIM-3, whose structure they had attempted to solve using x-ray crystallography.

In both cases, external researchers were able to download and reanalyze the authors’ own data from public data repositories, making it quickly apparent what had gone wrong and how it needed to be fixed — highlighting the very best of a scientific process that is supposed to be self-correcting and collaborative. Continue reading Structural biology corrections highlight best of the scientific process

Journal pulls parasite paper over potential for patient harm

Parasitology ResearchA journal has retracted a paper about a molecular diagnosis for leishmaniasis out of concern it could lead to incorrect clinical diagnoses. 

According to Parasitology Research, all data behind the figures in the main manuscript and supporting information are correct, but the authors’ misinterpretation of the data could lead doctors to diagnose patients incorrectly. 

Let’s take a look at the retraction notice, which tells us a bit more about the nature of the problem: Continue reading Journal pulls parasite paper over potential for patient harm

Nature fixes highly cited paper suggesting food additives hurt the gut

Nature_latest coverA 2015 study about dietary emulsifiers has been corrected by Nature after another researcher pointed out a few ambiguities.

When it first appeared, the study — which showed emulsifiers cause inflammation in the guts of mice — received a fair amount of media attention, including from Nature’s own news department. But since publication, a researcher noted some imprecision around the ages of mice used in the sample, affecting the paper’s calculations of weight gain over time. Andrew Gewirtz, co-author of the study from Georgia State University, told us the change did not affect the conclusions of the paper.

Here’s the corrigendum for “Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome”: Continue reading Nature fixes highly cited paper suggesting food additives hurt the gut

Doing the right thing: Authors share data, retract when colleague finds error

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A pair of chemical engineers has retracted a paper after another researcher was unable to replicate their work, in a case that we consider an example of doing the right thing.

Dennis Prieve, at Carnegie Mellon University, was interested in applying the paper — on how systems of molecules known as “reverse micelles” conduct electrical charge — to his own work, but was having trouble repeating the calculations. So Prieve contacted the authors — John Berg and his PhD student Edward Michor, based at the University of Washington — who supplied him with their original data.

It took several weeks of back and forth to figure out the problem, Michor told us, as the paper was published in 2012, so he had to decipher his old notes. When they found that several incorrect values were used in the paper, the authors issued a retraction notice, published in March:

Continue reading Doing the right thing: Authors share data, retract when colleague finds error

Dairy journal retracts paper lacking co-authors’ consent

Dairy science and technologyA journal about dairy science has retracted a paper after learning that it was published without the consent of all its authors.

An independent inquiry found no evidence of research misconduct, but nevertheless recommended that the institution — Curtin University in Perth, Australia — request to retract the paper.

Here’s the retraction notice, published in Dairy Science and Technology: Continue reading Dairy journal retracts paper lacking co-authors’ consent

“Mixed up” images earn biologists four retractions

525480Four different journals have pulled papers from the same authors due to alleged duplication or manipulation of images.

All four papers have two authors in common — Jianting Miao and Wei Zhang, both based at The Fourth Military Medical University in Xi’an City, Shaanxi, China. Many of the other co-authors are also listed in two or three of the retracted papers.

Miao claims that the photographs got “mixed up” due to the researchers’ “great carelessness” and “insufficient knowledge.” He told us:                                                                                                                                                                      

Continue reading “Mixed up” images earn biologists four retractions

Stem cell researchers fix two papers following PubPeer comments

Screen Shot 2016-04-13 at 5.56.09 PMA pair of stem cell researchers have earned two corrections, the result of images that were mislabeled, distorted, or compiled incorrectly, according to the notices.

Kang Cheng prepared the gels when he was a research fellow in last author Sanjeev Gupta‘s lab at the Albert Einstein College of Medicine. Gupta told us he reviewed the original gels, and the errors didn’t affect the conclusions in the papers, which were reproducible. He noted he believes the problems are the result of honest mistakes:

The errors did not confer any benefits whatsoever either for the papers or for Dr. Cheng.

On PubPeer, commenters have raised questions about the now corrected papers — along with several others on which Gupta is the senior author, but Cheng is not a co-author.

Edward Burns, research integrity officer at Einstein, told us that the medical school looked into an allegation of misconduct against Gupta:  

Continue reading Stem cell researchers fix two papers following PubPeer comments