Category: united states

Thalidomide paper retracted for lab error

fertstertResearchers at the University of Pittsburgh have retracted a paper on using thalidomide, which led to an estimated 10,000 birth defects by the time the drug was pulled from the market in 1961, to prevent chemo-induced sterility.

Alkylating agents, which prevent DNA replication in cells, are a commonly-used cancer treatment. Unfortunately they also damage the ovaries and testes, sometimes causing infertility. The University of Pittsburgh scientists published a paper in Elsevier journal Fertility and Sterility in 2011 that suggested thalidomide, which causes severe birth defects when used during pregnancy, might help protect ovaries during chemo.

However, according to the notice, the authors tried and failed to replicate their results. They had two separate scientists who were not authors take a look at the results; everyone agreed that the original study incorrectly reported the number of primordial follicles, the precursor to mature eggs.

Here’s the notice for “Thalidomide treatment attenuates chemotherapy-induced gonadal toxicity”: Continue reading Thalidomide paper retracted for lab error

Nature Cell Biology insulin paper retracted over antibody problems

nature cell biologyA Nature Cell Biology article on insulin regulation has been retracted after scientists noted that the antibodies used in their research were not as specific as they had previously believed.

The notice is clear on the problems with the science, which together “call into question the main conclusions of the paper.” Three of the paper’s five authors were employed at Novartis at the time of publication.

Here’s the notice for “Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion”: Continue reading Nature Cell Biology insulin paper retracted over antibody problems

Paper recommending calorie limits on Happy Meals retracted

Image via Stefan

A paper estimating the effects of limiting fast food meals with toys to under 550 calories has been retracted after concerns arose regarding the scientists’ use of an outdated model for estimating weight changes in kids.

The paper estimated that kids who eat fast food twice a week would avoid gaining two pounds a year if calorie limits are imposed on meals with toys. However, everyone we spoke to, and the notice, indicated that their estimate was inaccurate.

Here’s the notice for “Modeling Potential Effects of Reduced Calories in Kids’ Meals with Toy Giveaways”:

Continue reading Paper recommending calorie limits on Happy Meals retracted

PubPeer files motion to dismiss Sarkar defamation case

sarkarAttorneys representing PubPeer in its defense against a subpoena by cancer researcher Fazlul Sarkar, of Wayne State University in Michigan, have submitted a motion to the Wayne County Circuit Court to quash the matter.

Sarkar’s work has appeared on the anonymized post-publication peer review site, and he isn’t happy about it. In October, he sued the site’s commenters, demanding that PubPeer release the names of his accusers. Sarkar, who has not been found to have committed research misconduct, claims he lost a lucrative job offer at the University of Mississippi as a result of the posts.

The motion — available here — argues that even if the claims of image irregularities levied against Sarkar by anonymous PubPeer posters are untrue, they don’t meet conventional standards of defamation: Continue reading PubPeer files motion to dismiss Sarkar defamation case

Faking data earns stem cell researcher a ban on federal funding

Screen shot 2014-12-09 at 12.01.19 PMThe Office of Research Integrity (ORI) has sanctioned Kaushik Deb, a former post-doc at the University of Missouri-Columbia, who “engaged in misconduct in science by intentionally, knowingly, and recklessly” fabricating data in papers in both Science and Nature (which ultimately rejected his manuscript).

Deb was big news in 2007, when Science retracted his paper. Articles about the case appeared in many outlets, including The Scientist and USA Today. At the time, Missouri’s research integrity officer, Rob Hall, told the Columbia Tribune that: Continue reading Faking data earns stem cell researcher a ban on federal funding

JCI lymphoma paper retracted after authors can’t find underlying data to explain duplicated bands

Screen Shot 2014-11-25 at 5.12.55 PMA paper in the Journal of Clinical Investigation has been retracted for manipulated images, including duplicated bands in a Western blot.

Take a look at figure one to the right and see if you can spot all the doubles.

Click here for a more zoomable image.

Here’s the notice: Continue reading JCI lymphoma paper retracted after authors can’t find underlying data to explain duplicated bands

COPD paper in JCI retracted following PubPeer critiques

jciA 2011 paper in the Journal of Clinical Investigation whose PubPeer entry we highlighted in September has been retracted.

Here’s the notice for “Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients,” a 2011 paper by researchers at Johns Hopkins and Imperial College: Continue reading COPD paper in JCI retracted following PubPeer critiques

UNLV English professor fired for plagiarizing Updike, Said, Zizek, and more

via UNLV.
Mustapha Marrouchi, via UNLV

An English professor at the University of Nevada, Las Vegas, has been fired after the discovery that a huge portion of his work from the last two decades contains material lifted wholesale from some of the world’s best writers and thinkers.

Mustapha Marrouchi was first accused of plagiarism in 1992, when he ripped off an essay by W.J.T. Mitchell in the London Review of Books. Then in 1999, a letter by lecturer Stephen Howe appeared in the LRB, accusing Marrouchi of an “almost verbatim” theft of one of Howe’s book reviews: Continue reading UNLV English professor fired for plagiarizing Updike, Said, Zizek, and more

Three more retractions appear for Florida ob-gyn under investigation

University of Florida
Nasser Chegini via University of Florida

Two Oxford journals have now put out three more retractions for ob-gyn and former University of Florida professor Nasser Chegini, who has been under ORI investigation since at least 2012. That makes a total of five retractions, by our count.

Here is the notice for “The expression profile of micro-RNA in endometrium and endometriosis and the influence of ovarian steroids on their expression” in Molecular Human Reproduction: Continue reading Three more retractions appear for Florida ob-gyn under investigation

Second expression of concern appears for chemistry group under institutional review

chemsciThe journal Chemical Science has issued an expression of concern over a 2012 article by a pair of Texas researchers whose “unclick reaction” work has been under scrutiny by their institution.

The article, “Homonuclear bond activation using a stable N,N-diamidocarbene,” was written by Kelly M. Wiggins and Christopher W. Bielawski, of UT Austin. It’s the second EoC that we know of for a paper by Wiggins and Bielawski. We covered a previous one, from Science, that appeared in June.

Here’s the notice (pdf): Continue reading Second expression of concern appears for chemistry group under institutional review