Author: Dalmeet Singh Chawla

Amid controversial Sarepta approval decision, FDA head calls for key study retraction

FDAThe head of the U.S. Food and Drug Administration (FDA) has called for the retraction of a study about a drug that the agency itself approved earlier this week, despite senior staff opposing the approval.

On September 19, the FDA okayed eteplirsen to treat Duchenne muscular dystrophy (DMD), a rare genetic disorder that results in muscle degeneration and premature death. Several of its top officials disagreed with the drug’s approval, questioning how beneficial it will be for patients, as Forbes, MedPage Today and others reported.

In a lengthy report Commissioner Robert Califf sent to senior FDA officials on September 16 — that was made public on September 19 — he called for the retraction of a 2013 study published in Annals of Neurology funded by the seller of eteplirsen, which showed beneficial effects of the drug in DMD patients. Califf writes in the report:

Continue reading Amid controversial Sarepta approval decision, FDA head calls for key study retraction

Researcher in Ireland loses two 13-year old studies

journal-of-biological-chemistryThe Journal of Biological Chemistry (JBC) has retracted two 2003 studies after concluding that figures in the papers had been duplicated, and portions of some figures in one paper “did not accurately represent the results of the experimental conditions.”

The two newly retracted papers have the same last author — Therese Kinsella, a biochemist at the University College Dublin (UCD), who told us the data have been upheld by subsequent research, but that she supports the retractions, which are now part of a UCD investigation.

The retractions will bring up some familiar names: The first author on one of the papers is Sinéad Miggin from Maynooth University in the Republic of Ireland; in 2014, Miggin logged two retractions in the JBC, which triggered an investigation into co-author Aisha Qasim Butt. Last year, Maynooth University revoked Butt’s PhD after she admitted to “falsification and misrepresentation” of data in both studies as well as her PhD thesis. At the time, Miggin and two other researchers were fully exonerated by Maynooth University from “any wrongdoing.”

Butt, however, is not an author of either of the newly retracted papers. Although Butt’s LinkedIn page still lists her as a postdoctoral researcher at UCD, a spokesperson from the institution told us she is no longer based there.

We don’t often see such old papers retracted. Kaoru Sakabe, Manager of Publishing Issues at the American Society for Biochemistry and Molecular Biology, which publishes JBC, told us how this decision came about: Continue reading Researcher in Ireland loses two 13-year old studies

Would peer review work better if reviewers talked to each other?

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Katherine Brown

Would distributing all reviewers’ reports for a specific paper amongst every referee before deciding whether to accept or reject a manuscript make peer review fairer and quicker? This idea — called “cross-referee commenting” — is being implemented by the journal Development, as part of its attempt to improve the peer-review process. Katherine Brown, executive editor of Development from Cambridge, UK, who co-authored a recent editorial about the phenomenon, spoke to us about the move. 

Retraction Watch: Many journals share the reviews of a particular paper with those who’ve reviewed it. What is cross-referee commenting in peer review and how is it different from current reviewing processes? Continue reading Would peer review work better if reviewers talked to each other?

Renewable energy researcher with troubled record loses another paper

renewable-sustainable-energy-reviewsA renewable energy researcher who recycled material in several papers — and has already agreed to withdraw 10 studies — has lost another paper.

In January, we reported that six of 10 papers flagged by an investigation into author Shyi-Min Lu have either been retracted or withdrawn. Now, Lu has lost another paper that was not among the previous ten — again, for reproducing figures from earlier works without seeking permission from original authors. This paper was on a hot topic: gas hydrates, considered to be a potential new energy source to replace oil in the 21st century.

The investigations into Lu’s work took place at the Industrial Technology Research Institute in Hsinchu, Taiwan, where he was formerly based, and the National Taiwan University, in Taipei, Taiwan, which fired Lu from his position at the university’s energy research center.

Here’s the retraction notice in Renewable and Sustainable Energy Reviews, issued last month: Continue reading Renewable energy researcher with troubled record loses another paper

Journal to retract study declaring safety of asbestos roofs: Report

joehOnly a few months after publication, an environmental journal has told an activist group it plans to retract a paper about the safety of roofing products containing asbestos after facing heavy criticism.

This summer, Journal of Occupational and Environmental Hygiene (JOEH) received multiple letters asking the to retract the paper. Critics of the paper — which concluded that exposures to asbestos-containing roofing products were within safety limits — argued the article provided misleading information, grouped different materials with different asbestos exposures together, and failed to note the approving editor’s ties to the asbestos industry.

The article was published as a case study, which is considered a type of “column” by the journal, thereby bypassing its peer-review system; according to an email the journal sent to the organization Right on Canada (which a representative forwarded to Retraction Watch), this served as the basis for the journal’s decision to pull the paper.

According to the email, the journal’s editorial board decided on August 10 to retract “Airborne asbestos exposures associated with the installation and removal of roofing products” due to

Continue reading Journal to retract study declaring safety of asbestos roofs: Report

Authors retract 2016 cancer study when data don’t align with figures

cell-death-and-differentiationResearchers have retracted a 2016 cancer study, citing discrepancies between the data and images presented in the paper. 

Although the retraction notice itself contains relatively little information, we’ve obtained a letter from the last author — Jun-Li Luo of The Scripps Research Institute in Jupiter, Florida — to the editor-in-chief of Cell Death and Differentiation that says a bit more. 

According to the letter, after receiving the anonymous email, Luo conducted an investigation, contacting co-authors who contributed each of the figures in question. Although Luo writes that he has no reason to suspect fraud, the researchers were not able to provide some of the original data.

PubPeer commenters have questioned figures 1, 3, 4, 5, 6 and 7 in the study, “IKKα-mediated biogenesis of miR-196a through interaction with Drosha regulates the sensitivity of cancer cells to radiotherapy.”

In the letter, Luo tells Gerry Melino, co-editor-in-chief of the journal from the University of Leicester, UK, that figures 3D and 3E were provided by the study’s first author, Xing Fang, adding: Continue reading Authors retract 2016 cancer study when data don’t align with figures

Social networking site privacy breach complaint prompts retraction

patients-like-meA journal has removed a paper after realizing it contained a verbatim quote from a patient that could reveal the patient’s identity.

The journal learned of the slip-up after receiving a complaint from a social networking site for patients called PatientsLikeMe, which enables people with similar conditions to connect with each other. The retracted paper — ironically about automatically sanitizing private information on social networking sites — included a brief quote from an HIV-positive user of the site, containing specific dates and infections the patient had experienced.

The corresponding author of the study in Expert Systems and Applications confirmed to us that the letter from PatientsLikeMe about two lines of text in the study triggered its removal.

The journal has republished an updated version of the paper without the problematic text. 

Here’s an excerpt from the complaint, sent by Paul Wicks, Principal Scientist and Vice President of Innovation at PatientsLikeMe, to the researchers and the journal in December 2015: Continue reading Social networking site privacy breach complaint prompts retraction

Korean journal bans author for three years for plagiarism

journal-of-the-korean-data-and-information-science-societyA  journal in Korea has banned a researcher from submitting papers for three years after an investigation found evidence of plagiarism.

The retraction notice for “Goodness-of-fit tests for a proportional odds model,” which appears in the Journal of the Korean Data and Information Science Society, cites an investigation by an academic ethics committee, but it’s unclear where this review panel was based. 

Since the original retraction notice is in Korean, we’ve got it translated by One Hour Translation. It reads: Continue reading Korean journal bans author for three years for plagiarism

U.S. gov’t researchers withdraw climate paper after using pseudonyms

adv-space-resClimate scientists from the U.S. Department of Agriculture have withdrawn a study they wrote under eyebrow-raising pseudonyms.

The withdrawn paper, about predicting surface temperatures of planets, appeared in Advances in Space Research in August, 2015, and is authored by Den Volokin and Lark ReLlez.

Normally, a withdrawal wouldn’t raise our eyebrows, but climate scientist Gavin Schmidt pointed out on Twitter that the authors’ names are eerily similar to another pair who have published climate papers together: Ned Nikolov and Karl Zeller. Yes, that’s correct — Den Volokin and Lark ReLlez are Ned Nikolov and Karl Zeller spelled backwards. Nikolov and Zeller are currently listed as a physical scientist and a meteorologist, respectively, at the U.S. Department of Agriculture.

The notice doesn’t state the reason for withdrawal, and Pascal Willis, editor-in-chief of Advances in Space Research from the Earth Physics Institute in Paris, France, referred us to the study’s authors for more information. Elsevier, which publishes Advances in Space Research, confirmed that the paper was retracted due to an “authorship issue” — namely, that the authors had used pseudonyms.

We used the contact information listed on the paper for “Den Volokin,” and got this response: Continue reading U.S. gov’t researchers withdraw climate paper after using pseudonyms

We have an epidemic of deeply flawed meta-analyses, says John Ioannidis

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John Ioannidis, via Stanford University

John Ioannidis, a professor at Stanford University and one of the most highly cited researchers in the world, has come up with some startling figures about meta-analyses. His new paper, published today in Milbank Quarterly (accompanied by this commentary), suggests that the number of systematic reviews and meta-analyses in literature have each increased by more than 2500% since 1991. We asked Ioannidis — who is perhaps most well known for his 2005 paper “Why Most Published Research Findings Are False” (and was featured in a previous Retraction Watch Q&A article) — why such a massive boost these publication types in scholarly literature is potentially harmful. 

Retraction Watch: You say that the numbers of systematic reviews and meta-analyses have reached “epidemic proportions,” and that there is currently a “massive production of unnecessary, misleading, and conflicted systematic reviews and meta-analyses.” Indeed, you note the number of each has risen more than 2500% since 1991, often with more than 20 meta-analyses on the same topic. Why the massive increase, and why is it a problem? Continue reading We have an epidemic of deeply flawed meta-analyses, says John Ioannidis