Category: by subject

Leading cancer scientist retracts two papers, one 14 years old, but journal won’t say why

One of the world’s leading cancer researchers, Axel Ullrich of Germany, has retracted two papers published in the Journal of Biological Chemistry.

Ullrich, director of microbiology at the Max Planck Institute of Biochemistry, has been a central figure in many groundbreaking discoveries, from the development of genetically engineered insulin to the identification of the breast cancer gene HER2. The founder of several biotech firms, he also runs an international consortium, the Singapore Oncogenome Project, looking for other so-called oncogenes linked to protein-tyrosine kinase, or PTK, an enzyme that regulates cell growth and which, when run amok, is implicated in a variety of tumor types.

The retractions involve two articles, published eight years apart, on protein-tyrosine. The first, from 1996, was titled Continue reading Leading cancer scientist retracts two papers, one 14 years old, but journal won’t say why

Scientist raised serious questions about 2008 Cell study by Amy Wagers

Amy Wagers, a Harvard stem cell researcher, retracted a Nature study last week and has another published paper under scrutiny at Blood. Retraction Watch has now learned that a 2008 Cell paper she co-authored drew significant criticism from a stem cell researcher at Children’s National Medical Center.

In the paper, Wagers and her team said they were able to prepare a set of muscle cells that reversed some of the effects of muscular dystrophy in a mouse model of the disease. In a 2008 letter to the editor of Cell, however, Terence Partridge wrote Continue reading Scientist raised serious questions about 2008 Cell study by Amy Wagers

Another stem cell paper retracted, for “breach of established ethical guidelines”

Last week’s big Retraction Watch news — which got us quoted in the New York Times — was a Nature paper by Amy Wagers and Shane Mayack. The now-retracted paper suggested that the aging of stem cells could be reversed, and Blood has issued a notice of concern about a second paper.

Now comes news about another stem cell finding. The International Journal of Urology has retracted a 2009 paper by Japanese researchers who claimed to have used stem cells derived from fatty tissue to treat urinary incontinence in two men. The men had developed bladder problems after undergoing surgery to remove their cancerous prostates.

According to the editor’s note, the article Continue reading Another stem cell paper retracted, for “breach of established ethical guidelines”

Editor of another journal where Wagers and Mayack published an abstract is monitoring the situation

Yesterday, we noted that Amy Wagers and Shane Mayack have published five papers together. One of those, published earlier this year in Nature, was retracted Wednesday, and another is now the subject of a “notice of concern” from Blood.

We wanted to find out about some of the other papers published by Wagers and Mayack, so we contacted the editor of Developmental Biology, which published one of them. They have not heard from Wagers or Harvard, but are monitoring developments, according to editor in chief Robb Krumlauf: Continue reading Editor of another journal where Wagers and Mayack published an abstract is monitoring the situation

Errors, phantom author, retraction? It’s enough to set your teeth on edge

 

Photo by mattlemmon via flickr http://www.flickr.com/photos/mplemmon/

 

Authorship issues, sloppy science, deception — more often than not, at least one of these is at the heart of a retracted paper. But it’s rare when all three are involved. Which, of course, means that such a case is precisely what we’re about to deliver.

The Journal of Medical Case Reports, a BioMed Central title, recently retracted an intriguing item about a young man who developed a condition called pubic osteomyelitis after becoming infected with Streptococcus viridans following oral surgery to pull a wisdom tooth. As the authors, from Great Britain, explained in their 2008 paper describing the episode: Continue reading Errors, phantom author, retraction? It’s enough to set your teeth on edge

Blood posts “notice of concern” over second Wagers-Mayack paper

A day after an up and coming Harvard stem cell scientist retracted a Nature paper, Blood has issued a notice of concern about another paper by the same group, published in August 2008, the Boston Globe reports. Such notices often, but not always, precede retractions.

According to the notice for “Osteolineage niche cells initiate hematopoietic stem cell mobilization”: Continue reading Blood posts “notice of concern” over second Wagers-Mayack paper

Highly cited Harvard stem cell scientist retracts Nature paper

courtesy Nature

Amy Wagers, an up and coming stem cell researcher at Harvard who made a name for herself as a postdoc early by questioning the work of others, has retracted a January 2010 paper she co-authored in Nature. According to the retraction:

Three of the authors (J.L.S., F.S.K. and A.J.W.) wish to retract this Article after a re-examination of the publication raised serious concerns with some of the reported data. These concerns have undermined the authors’ confidence in the support for the scientific conclusions reported, specifically the role of osteopontin-positive niche cells in the rejuvenation of haematopoietic stem cells in aged mice. Although this matter is under further review, these authors wish to retract the paper in its entirety, and regret any adverse consequences that may have resulted from the paper’s publication. The retraction has not been signed by Shane R. Mayack, who maintains that the results are still valid.

What’s going on at Haematologica? Journal double-publishes three different studies

Sometimes, studies are so nice, you want to print them twice. But when that happens three times within a year, well, maybe it’s not so nice. Consider the following three retractions, which appeared on a single page of Haematologica last month.

One:

The Haematologica Production Office erroneously double-published the article entitled “P39/Tsugane cells are a false cell line contaminated with HL-60 cells and are not suitable for mechanistic studies in myelodysplastic syndromes” by David P. Steensma. Haematologica. 2010 Feb 23. [Epub ahead of print] with doi:10.3324/haematol.2009.022988 . This article must therefore be considered as retracted, as the correct version of the same article has been correctly published on July 1, 2010, as doi:10.3324/haematol.2010.022988. Haematologica sincerely apologizes to the authors and the readers for this mistake.

Two: Continue reading What’s going on at Haematologica? Journal double-publishes three different studies

2009 Cell paper on muscular dystrophy gene link retracted

A Cell paper reporting on genetic mutations responsible for a form of muscular dystrophy was retracted earlier this month. According to the retraction:

Our paper reported the identification of mutations in the gene VMA21 in patients with X-linked myopathy with excessive autophagy (XMEA) and characterized the molecular mechanisms underlying the disease phenotype. Many of the figure panels in the paper summarize data from multiple experiments. We have now detected a number of errors in these panels. Although we stand by the validity of our conclusions, we believe that the most responsible course of action is to retract our paper. We are preparing an expanded version of our work for future submission. We deeply regret this circumstance and apologize to the community.

One of the original authors, Dr. Aubourg, could not be reached regarding this Retraction.

The study has been cited 11 times, according to Thomson Scientific’s Web of Knowledge. Here’s a press release the researchers’ hospital, Sick Kid’s of Toronto, sent out when it was originally published.

Nobelist Linda Buck retracts two studies on olfactory networks — and the news is embargoed

Well, it’s happened: The Embargo Watch and Retraction Watch worlds have collided. I had initially figured on two posts here, but it soon became clear that how journals were handling these retractions, using embargoes, was central to both. So this is being cross-posted on both blogs.

Linda Buck, who shared the 2004 Nobel Prize in Physiology or Medicine, has retracted two papers published in 2005 and 2006. Both retractions — one in the Proceedings of the National Academy of Sciences (PNAS) and one in Science — appear online today.

The papers describe how nerves that carry information about scents connect from the nose to the olfactory bulb, where they are processed. They were published after the 2004 Nobel, which was for discoveries “of odorant receptors and the organization of the olfactory system.”

The retractions come two and a half years after Buck retracted a 2001 Nature paper co-authored with Zhihua Zou, a post-doc in her then-Harvard lab. She’s been at the Fred Hutchinson Cancer Research Center since 2002, and is a Howard Hughes Medical Institute investigator. In 2008, Nature’s news section reported:

Harvard Medical School has formed an ad hoc committee to review the retraction, and Buck has asked the Fred Hutchinson Cancer Research Center to review two later publications on which Zou was the lead author. “It’s disappointing of course,” says Buck. “The important thing is to correct the literature.”

The PNAS and Science retractions are of those two later publications. The PNAS study was cited 61 times, and the Science study was cited 73 times, according to the Thomson Scientific Web of Knowledge.

The Science retraction reads: Continue reading Nobelist Linda Buck retracts two studies on olfactory networks — and the news is embargoed