Category: clinical study retractions

Antifungal drug paper didn’t have institution’s approval

Authors have pulled a paper on an antifungal drug that is potentially toxic because it lacked final approval from their institution.

The study describes a patient who had experienced liver toxicity after taking voriconazole. During the study, the authors re-administered the drug to the patient using “a slow dose titration.” But their institution didn’t approve the study before it was published online.

Here’s the retraction note for “Successful Rechallenge with Voriconazole following Medication-Induced Hepatotoxicity,” published in Antimicrobial Agents and Chemotherapy.  Continue reading Antifungal drug paper didn’t have institution’s approval

Corrections chip away at asbestos paper for conflicts of interest, “misleading” citation

EBPHThe journal Epidemiology Biostatistics and Public Health has issued back-to-back corrections for a 2015 paper after the authors failed to disclose conflicts of interest with the asbestos industry and included an “erroneous citation.”

The mistaken citation was more than just a clerical error, critics argue — it undermines one of the key arguments of the paper, “Critical reappraisal of Balangero chrysotile and mesothelioma risk,” which disputes claims that an asbestos mine in northwest Italy was responsible for numerous cases of an aggressive form of cancer called mesothelioma. The authors, led by Edward Ilgren formerly of Oxford University, claim that “myriad sources” of other forms of asbestos—rather than the asbestos produced at the mine, called chrysotile—exist in the region “to account for the alleged cases.”

However, according to a recently added correction, the citation does not support one of the authors’ claims about how other forms of asbestos arrived at the mine area.

Continue reading Corrections chip away at asbestos paper for conflicts of interest, “misleading” citation

Retracted anesthesia study “was not conducted in reality”

coverWe’ve come across a new way to say the data in a paper are not reliable:

It has been found that the study represented in the article was not conducted in reality.

That’s from the retraction note for a paper that Anesthesia Essays and Researches has retracted for data falsification. The rest of the retraction note for “Intrathecal dextmedetomidine to reduce shoulder tip pain in laparoscopic cholecystectomies under spinal anesthesia” explains:

Continue reading Retracted anesthesia study “was not conducted in reality”

NEJM corrects 3 papers after prominent cancer scientist left off credit for breakthrough

Screen Shot 2016-03-15 at 12.04.43 PMThe New England Journal of Medicine has corrected three highly cited papers to credit researchers who played a role in the work.

The papers describe a treatment in which engineered T cells fight leukemia, originally hailed as a “major advance” in the New York Times. Since the first paper appeared in 2011, co-author Carl June at the University of Pennsylvania has received more than $7 million in grants from the National Institutes of Health, according to MIT Technology Review. But according to a newly published correction, the three NEJM papers failed to note in the acknowledgement section that an important component of the experiments was supplied by researchers at St. Jude Children’s Research Hospital.

The correction, made 11 months after a request from co-author and Penn researcher David Porter, explains the contribution of the St Jude’s researchers:

Continue reading NEJM corrects 3 papers after prominent cancer scientist left off credit for breakthrough

Another paper by GM researcher pulled over manipulation concerns

Screen Shot 2016-03-14 at 11.52.18 AMA researcher who published findings questioning the safety of genetically modified organisms has lost a second paper following concerns of image manipulation.

Last week, the journal animal retracted a 2010 paper by Federico Infascelli, an animal nutrition researcher at the University of Naples, which claimed to find modified genes in the milk and blood of goats who were fed genetically modified soybeans. The retraction stems from an investigation that concluded the authors likely manipulated images, according to the note. Earlier this year, another journal retracted one of Infascelli’s papers that contained a duplicated figure.

In February, Italian paper La Repubblica (which we read with Google Translate) reported that the university found problems in three of his articles and issued a warning.

Here’s the retraction note for “Fate of transgenic DNA and evaluation of metabolic effects in goats fed genetically modified soybean and in their offsprings:”

Continue reading Another paper by GM researcher pulled over manipulation concerns

Journal bans 8 authors for plagiarism

67

A medical journal has banned eight authors after discovering that they had published plagiarized work.

We don’t see official author bans as often as we see plagiarism (occasionally, and all the time, respectively). That’s why we’re flagging this case, which is a little old — the International Journal of Medical Science and Public Health announced the ban in March 2015, after it retracted three of the authors’ papers for plagiarism.

All three papers — about recovering from orthopedic problems — have a first author in common: Rajesh Valjibhai Chawda, who was affiliated with the CU Shah Medical College and Hospital in India at the time of the research. (We couldn’t find a webpage for him.)

After an author on one of the original articles alerted the journal of one instance of plagiarism, the journal launched an in-house inquiry, the retraction note explains:

Continue reading Journal bans 8 authors for plagiarism

PLOS ONE retracting paper that cites “the Creator”

Screen Shot 2016-01-19 at 10.50.25 AMPLOS ONE has retracted a paper published one month ago after readers began criticizing it for mentioning “the Creator.”

The article “Biomechanical Characteristics of Hand Coordination in Grasping Activities of Daily Living” now includes a reader comment from PLOS Staff, noting: Continue reading PLOS ONE retracting paper that cites “the Creator”

Surgery studies lacked ethics committee approval

3Surgery Today has pulled a pair of papers that share many authors because the studies they describe were not approved by an institutional ethics committee.

One describes a case in which the researchers removed a mass from a 64-year-old woman’s small intestine; the other describes how the authors removed a growth from a patient’s pancreas. They conclude that the surgery techniques used — like a laparoscopic pancreaticoduodenectomy, a take on the “Whipple Procedure” — can be “feasible, safe, and effective” in certain patients.

The papers share several authors, including a first author, Akihiro Cho, whose affiliation on the papers is Chiba Cancer Center Hospital in Japan. They also share a retraction note, which explains how the journal learned of the issue:

Continue reading Surgery studies lacked ethics committee approval

Top journals give mixed response to learning published trials didn’t proceed as planned

Ben Goldacre
Ben Goldacre

Ben Goldacre has been a busy man. In the last six weeks, the author and medical doctor’s Compare Project has evaluated 67 clinical trials published in the top five medical journals, looking for any “switched outcomes,” meaning the authors didn’t report something they said they would, or included additional outcomes in the published paper, with no explanation for the change. The vast majority – 58 – included such discrepancies. Goldacre talked to us about how journals – New England Journal of Medicine (NEJM), JAMA, The Lancet, BMJ, and Annals of Internal Medicine — have responded to this feedback.

Retraction Watch: When you discover a published trial has switched outcomes, what do you do? Continue reading Top journals give mixed response to learning published trials didn’t proceed as planned

Methodology of paper linking vaccine to behavioral issues “seriously flawed,” says retraction

S0264410X

After temporarily removing a paper that suggested a link between the vaccine for the human papillomavirus (HPV) and behavioral issues, the journal has now retracted it.

Vaccine says the reason is “serious concerns regarding the scientific soundness of the article,” including flawed methodology and unjustified claims.

Christopher A. Shaw, a co-author on the paper and a researcher at the University of British Columbia, told us he has seen the notice, but doesn’t know the specific issues the journal had with the paper:

We still don’t know why [Editor in Chief] Dr Poland removed the article.

Here’s the retraction notice for “Behavioral abnormalities in young female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil:”

Continue reading Methodology of paper linking vaccine to behavioral issues “seriously flawed,” says retraction