Category: clinical study retractions

Ketamine for depression? Paper retracted for error that double-counted clinical trial participants

A psychiatry journal has retracted a 2015 meta-analysis on the effectiveness of ketamine for depression after readers found that the article double-counted patients in some studies, thereby inflating the apparent benefits of the drug.

The article, “Efficacy of ketamine in bipolar depression: systematic review and meta-analysis,” was published in the Journal of Psychiatric Practice by a group from the United States and England. But a pair of researchers in Sweden noticed the duplication — and what seems to have been a rather slapdash approach to the work — and pushed to have the paper retracted.

According to the results section of the abstract: Continue reading Ketamine for depression? Paper retracted for error that double-counted clinical trial participants

In a first, U.S. CDC retracts, replaces study about suicide risk in farmers

In a first for the CDC, the agency’s premier scientific publication has retracted a 2016 article on suicide, five months after a news story pointed out serious errors in the paper.

The article, initially published as “Suicide Rates by Occupational Group — 17 States, 2012,” had purported to find that farmers were at particularly high risk of suicide. That result in particular caught the attention of a website called The New Food Economy (TNFE), which last June called out what it said were errors in the CDC’s analysis. And on June 29, the journal, the Morbidity and Mortality Weekly Report (MMWR), issued a reader’s note.

As TNFE wrote, the crux of the mistake involves the misclassification of farmer suicides in a way that significantly inflated the rate of these events — errors the website said it first raised with the CDC in April 2018: Continue reading In a first, U.S. CDC retracts, replaces study about suicide risk in farmers

A convicted felon writes a paper on hotly debated diets. What could go wrong?

Richard Fleming

Pro-tip for journals and publishers: When you decide to publish a paper about a subject — say, diets — that you know will draw a great deal of scrutiny from vocal proponents of alternatives, make sure it’s as close to airtight as possible.

And in the event that the paper turns out not to be so airtight, write a retraction notice that’s not vague and useless.

Oh, and make sure the lead author of said study isn’t a convicted felon who pleaded guilty to healthcare fraud.

If only we were describing a hypothetical. Continue reading A convicted felon writes a paper on hotly debated diets. What could go wrong?

Caveat scriptor: How a journal editor unraveled the mystery of the overlapping bad data

John Loadsman

Caveat scriptor—writer beware.

That’s the moral of a recent editorial in the Saudi Journal of Anesthesia, prompted by the retraction in that journal of a 2014 paper with bum data.

The editorial was written by John Loadsman, an anesthesiologist in Sydney, Australia, and editor of the journal Anaesthesia and Intensive Care, who played a role in the retraction. Here’s how.

According to Loadsman, he was considering an article for his journal — a meta-analysis of previously published findings. On inspection, he he noticed that some of the studies cited in the meta-analysis were potentially problematic, including Continue reading Caveat scriptor: How a journal editor unraveled the mystery of the overlapping bad data

The “regression to the mean project:” What researchers should know about a mistake many make

David Allison, via IU

The work of David Allison and his colleagues may be familiar to Retraction Watch readers. Allison was the researcher — then at the University of Alabama, Birmingham, now at Indiana University — who led an effort to correct the nutrition literature a few years ago. He and his colleagues are back, this time with what might be called the “Regression to the Mean Project,” an attempt to fix a problem that seems to vex many clinical trials. You may have noticed some items in Weekend Reads about letters to the editor that mention the issue. Here, Allison explains.

•Retraction Watch (RW): First, what is “regression to the mean,” and what does it mean for clinical studies? Continue reading The “regression to the mean project:” What researchers should know about a mistake many make

“Sufficiently serious” issues in study prompt company to yank drug approval application in China

The maker of a leading over-the-counter antacid has withdrawn its application for approval of the drug in China because a clinical trial of the product in that country was marred by “major protocol deviations.”

Researchers for the company, Reckitt Benckiser, maker of Gaviscon, had published a report on the study in 2015 in the journal Alimentary Pharmacology & Therapeutics. But the journal has now retracted the article, “Randomised clinical trial: The clinical efficacy and safety of an alginate‐antacid (Gaviscon Double Action) versus placebo, for decreasing upper gastrointestinal symptoms in symptomatic gastroesophageal reflux disease (GERD) in China,” at the behest of the drug maker.

According to the notice: Continue reading “Sufficiently serious” issues in study prompt company to yank drug approval application in China

Harvard and the Brigham recommend 31 retractions for cardiac stem cell work

Piero Anversa

Retraction Watch readers may be familiar with the name Piero Anversa. Until several years ago, Anversa, a scientist at Harvard Medical School and the Brigham and Women’s Hospital, was a powerful figure in cardiac stem cell research.

“For ten years, he ran everything,” says Jeffery Molkentin, a researcher at Cincinnati Children’s whose lab was among the first to question the basis of Anversa’s results in a 2014 paper in Nature. Continue reading Harvard and the Brigham recommend 31 retractions for cardiac stem cell work

Japanese university revokes PhD following a retraction

Tokyo Women’s Medical University has stripped a researcher of her PhD, following the retraction of a paper — for data duplication — that was based on her thesis.

The August 30th announcement notes that a degree was revoked on July 20. The announcement does not name the researcher, but refers to degree number 2881, which corresponds to Rika Nakayama’s PhD. The university describes carelessness and errors, but not misconduct.

Here’s a rough Google translation of the announcement: Continue reading Japanese university revokes PhD following a retraction

When it comes to retracting papers by the world’s most prolific scientific fraudsters, journals have room for improvement

Journals have retracted all but 19 of the 313 tainted papers linked to three of the most notorious fraudsters in science, with only stragglers left in the literature. But editors and publishers have been less diligent when it comes to delivering optimal retraction notices for the affected articles.

That’s the verdict of a new analysis in the journal Anaesthesia, which found that 15% of retraction notices for the affected papers fail fully to meet standards from the Committee for Publication Ethics (COPE). Many lacked appropriate language and requisite watermarks stating that the articles had been removed, and some have vanished from the literature.

The article was written by U. M. McHugh, of University Hospital in Galway, Ireland, and Steven Yentis, a consultant anaesthetist at Chelsea & Westminster Hospital in London. Yentis was editor of Anaesthesia during the three scandals and had a first-hand view of two of the investigations. He also is the editor who unleashed anesthetist and self-trained statistician John Carlisle on the Fujii papers to see how likely the Japanese researcher’s data were to be valid (answer: not very likely). Continue reading When it comes to retracting papers by the world’s most prolific scientific fraudsters, journals have room for improvement

Distraction paper pulled for clerical error

The authors of a 2018 paper on how noisy distractions disrupt memory are retracting the article after finding a flaw in their study.

The paper, “Unexpected events disrupt visuomotor working memory and increase guessing,” appeared in Psychonomic Bulletin & Review, a publication of the Psychonomic Society. (For those keeping score at home, psychonomics is the study of the laws of the mind.)

The article purported to show that an unexpected “auditory event,” like the sudden blare of a car horn, reduced the ability of people to remember visuomotor cues. Per the abstract:

Continue reading Distraction paper pulled for clerical error