Category: diabetes

How can we improve preclinical research? Advice from a diabetes researcher

Daniel Drucker
Daniel Drucker

By all accounts, science is facing a crisis: Too many preclinical studies aren’t reproducible, leading to wasted time and effort by researchers around the world. Today in Cell Metabolism, Daniel Drucker at the Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital in Toronto details numerous ways to make this early research more robust. His most important advice: more transparent reporting of all results (not just the positive findings), along with quantifying, reporting, tracking, and rewarding reproducibility, for both scientists and journals and universities/research institutes.

Retraction Watch: Which of your recommendations will researchers most object to, and why? Continue reading How can we improve preclinical research? Advice from a diabetes researcher

Journal flags two papers by prominent diabetes researcher, more questioned on PubPeer

DiabetesDiabetes has issued two expressions of concern (EOCs) for papers co-authored by leading diabetes researcher Kathrin Maedler, adding to her previous count of one retraction and three corrections.

Both papers were questioned on PubPeer, alongside several others co-authored by Maedler, who is based at the University of Bremen in Germany. As we previously reported, PubPeer comments have led to one retraction for Maedler in the Journal of Biological Chemistry (JBC), and corrections in various other journals.

One of those corrections has now earned an EOC from Diabetes, which also extends to the original paper. Here are the notices, which asks the University of Bremen to investigate further:  Continue reading Journal flags two papers by prominent diabetes researcher, more questioned on PubPeer

Researcher whose PhD was revoked is no longer at Harvard lab

mend.2016.30.issue-8.coverA research fellow at Harvard Medical School whose PhD was revoked last month is no longer working in his former lab, Retraction Watch has learned. 

An archived version of the lab site for Alfred Goldberg from December, 2015, lists Sudarsanareddy Lokireddy as a postdoctoral fellow; however, Goldberg’s current lab site doesn’t include Lokireddy as a lab member.

We contacted Goldberg’s lab, and he was unavailable for comment. We were told all of his lab members are on the current website.

Lokireddy has also logged his sixth retraction. But this case isn’t as straightforward as it seems.

Continue reading Researcher whose PhD was revoked is no longer at Harvard lab

Researcher who sued to stop retractions earns his 7th

Mario Saad
Mario Saad

A diabetes researcher who sued to stop a publisher from retracting his papers has just received his seventh retraction.

The latest retraction for Mario Saad, who is based at the University of Campinas (Unicamp) in São Paulo, Brazil, is for a PLOS ONE paper (which was altered last year by a mega-correction). Although an institutional investigation found no evidence of research misconduct, the notice states:

the preparation of the figures falls below the standard of publication and therefore the authors and the editors have agreed that the correct action is to retract the article. 

Saad previously sued the American Diabetes Association (ADA) to remove expressions of concern from four of his papers published in the organisation’s flagship journal, Diabetes. However, all four of the papers were later retracted after the suit was dismissed in 2015.

Here’s the new retraction notice, issued July 8: Continue reading Researcher who sued to stop retractions earns his 7th

Authors who lost paper linking fecal transplants to obesity have another retracted

International Journal of ObesityAn obesity journal has retracted a study by authors who previously lost another paper that suggested a link between the fecal microbiome and obesity.

We first came across on the now-retracted paper in the International Journal of Obesity (IJO) in April when we reported on the authors’ other retraction in Diabetes. The 2014 paper had a corrigendum, published the same year, and also for image-related issues. Since then, however, the journal has pulled the IJO paper and its associated corrigendum at the request of the French National Institute of Agronomic Research (INRA) in Paris. Continue reading Authors who lost paper linking fecal transplants to obesity have another retracted

Diabetes researcher logged 1 retraction, 3 correx, after PubPeer comments

Kathrin Maelder
Kathrin Maedler

A journal has retracted a paper by a leading diabetes researcher — who has also issued three corrections — after questions about her research were raised on PubPeer.

Kathrin Maedler — who works at the University of Bremen in Germany — corrected another paper in 2014. All of the notices are dated from 2015, and all describe issues with figures.

The ongoing comments have led Maedler to carefully look through her original data, according to a statement she emailed us: Continue reading Diabetes researcher logged 1 retraction, 3 correx, after PubPeer comments

Researcher who sued to stop retractions gets his sixth

Mario Saad
Mario Saad

A sixth retraction has appeared for a diabetes researcher who previously sued a publisher to try to stop his papers from being retracted.

Mario Saad‘s latest retraction, in PLOS Biology, stems from inadvertent duplications, according to the authors.  Though an investigation at Saad’s institution — the University of Campinas in Brazil — found no evidence of misconduct, a critic of the paper told The Scientist he does not believe that the issues with blots were inadvertent.

Previously, Saad sued the American Diabetes Association to remove four expressions of concern from his papers; they were later retracted, even though Unicamp recommended keeping three of them published.

Here’s the new retraction notice, for “Gut Microbiota Is a Key Modulator of Insulin Resistance in TLR 2 Knockout Mice:” Continue reading Researcher who sued to stop retractions gets his sixth

Researcher who unsuccessfully sued journal to stop retractions earns another expression of concern

Mario Saad
Mario Saad

A journal has added expressions of concern (EOCs) to four papers about diabetes, including one co-authored by an author who previously sued a different journal when it took a similar action on his papers.

The Journal of Physiology flagged the papers after an investigation “could not rule out the possibility” that they contained duplicated Western blots. Though the three other papers do not include Mario Saad on their author list, he plays a role: The papers include blots duplicated from other papers of Saad’s. And they reveal that Saad may have published those blots multiple times in his own work.

The EOCs all start out with the same statement: Continue reading Researcher who unsuccessfully sued journal to stop retractions earns another expression of concern

Paper linking fecal transplants to obesity in rats retracted for faked data

Diabetes Cover

A paper linking the fecal microbiome to obesity has been retracted after it became clear that one of the co-authors faked some of the data.

The 2014 paper in Diabetes — which found that rats given fecal transplants from obese mice were more likely to become obese themselves if given a particular diet — was pulled after after an institutional investigation found a co-author guilty of falsifying data underlying one figure and fabricating the data of two others.

Co-author Yassine Sakar — formerly based at the French National Institute of Agronomic Research (INRA) in Paris, France — was found responsible for the misconduct. But an official from the institution said that some responsibility must also be shared by the corresponding author Mihai Covosa, who has since resigned from the institution.

Here’s the retraction notice: Continue reading Paper linking fecal transplants to obesity in rats retracted for faked data

NEJM quickly corrects disclosure statement, errors in diabetes paper

NEJM LogoAfter publishing a paper about neuropathy in diabetic patients last week, The New England Journal of Medicine (NEJM) immediately corrected it after editors learned of errors and some missing disclosures within the article.

The notice explains that the sole author of the paper, “Diabetic Sensory and Motor Neuropathy,” reported incorrect doses for several medications, and received royalties for the tool to measure quality of life used in the paper. The author told us all the declarations were “discussed in detail” between him and the journal, and both parties agreed to the final decision. 

Let’s take a look at the lengthy correction notice — what some of our readers might call a “mega-correction:” Continue reading NEJM quickly corrects disclosure statement, errors in diabetes paper