Category: basic life sciences retractions

Authors retract heart disease paper for “nonscientific reason”

Researchers have retracted a 2018 paper about the genetic underpinnings of heart disease from the FASEB Journal — and it’s not entirely clear why.

The paywalled retraction notice simply cites a “nonscientific reason.” Cody Mooneyhan, the director of publications at the journal, declined to provide further details, and the authors have provided different accounts of what happened: The paper’s corresponding author, John Yu, told Retraction Watch that he requested the retraction because the first author, Chia‐Ti Tsai, refused to sign the journal’s copyright agreement. Tsai, a professor in the Department of Internal Medicine at National Taiwan University in Taipei, told us he was “not notified before the paper was submitted.” Continue reading Authors retract heart disease paper for “nonscientific reason”

Infamous case of fraud by protein crystallographer ends in 10-year funding ban

In 2009, a university announced a prominent researcher in the field of protein crystallography had likely fabricated nearly a dozen protein structures. Nine years later, the U.S. Office of Research Integrity (ORI) has upheld the results — and announced a relatively long sanction, by the agency’s standards.

Today, the ORI placed a 10-year ban on Federal funding for H.M. Krishna Murthy, a former research associate professor at the University of Alabama at Birmingham (UAB), noting he “falsified and/or fabricated” research in nine papers and multiple structures added to a widely used database. Four of the papers have already been retracted; two others have been flagged with an expression of concern by the journal. Three remain otherwise intact.

The announcement was a long time coming — after the ORI provided Murthy with its initial finding and proposed sanctions, he appealed. On January 19, 2018, and Administrative Law Judge declined to move forward with the appeal, allowing the agency to proceed. Today’s finding was accompanied by a rare message from the interim office of the director, Wanda Jones, in which she notes today’s announcement:

Continue reading Infamous case of fraud by protein crystallographer ends in 10-year funding ban

Caught Our Notice: Researcher who once threatened to sue Retraction Watch now up to 19 retractions

Title: Curcumin-Free Turmeric Exhibits Activity against Human HCT-116 Colon Tumor Xenograft: Comparison with Curcumin and Whole Turmeric

What Caught Our Attention: We haven’t heard much about Bharat Aggarwal since his seven retractions in 2016 propelled him onto our leaderboard (and long after he threatened to sue Retraction Watch for our reporting). There was a whisper of a mention, when his name was listed as one of the organizers of a cancer conference from which MD Anderson (his former employer) had to publicly distance themselves as a co-sponsor. Continue reading Caught Our Notice: Researcher who once threatened to sue Retraction Watch now up to 19 retractions

Caught Our Notice: 54 problems in three scientific images equals one expression of concern

Title: Effects of microRNA-223 on morphine analgesic tolerance by targeting NLRP3 in a rat model of neuropathic pain

What Caught Our Attention: Usually, an Expression of Concern (EOC) offers general language about “concerns regarding the validity of the data” or “concerns regarding the integrity of the study.” Here the language is anything but, saying that 54 Western blot bands within three figures have problems such as “visible pasted joints,” “square border,” and numerous “appear to be the same band.”  According to the notice, the authors have not responded to requests for the original blots, so the editors are allowing the article to remain intact, choosing instead “to alert readers to these issues and allow them to arrive at their own conclusions regarding the figures.” Continue reading Caught Our Notice: 54 problems in three scientific images equals one expression of concern

Caught Our Notice: Researcher who sued PubPeer commenter up to 21 retractions

Titles: 1) Notch-1 induces Epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells

2) Sensitization of squamous cell carcinoma to cisplatin induced killing by natural agents

What Caught Our Attention: Regular readers will be familiar with the saga involving Fazlul Sarkar and PubPeer: In 2014, Sarkar sued anonymous commenters on the site, claiming defamation (and that damaging comments may have cost him a new job). Although Sarkar won an initial ruling, it was overturned by an appeals court. In the midst of that, the ACLU (which represented PubPeer in the case) released a copy of a misconduct investigation report compiled by Sarkar’s institution, Wayne State University, which concluded that he had committed enough misconduct to warrant retracting 40 papers. The two latest notices, both of which cite Wayne State’s investigation, bring Sarkar’s total to 21.   Continue reading Caught Our Notice: Researcher who sued PubPeer commenter up to 21 retractions

Caught Our Notice: Climate change leads to more…neurosurgery for polar bears?

Title: Internet Blogs, Polar Bears, and Climate-Change Denial by Proxy

What Caught Our Attention: There’s a lot going on here, so bear with us. (Ba-dum-bum.)

First, there was the paper itself, co-authored by, among others, Michael Mann and Stephan Lewandowsky. Both names may be familiar to Retraction Watch readers. Mann is a prominent climate scientist who has sued the National Review for defamation. A study by Lewandowsky and colleagues of “the role of conspiracist ideation in climate denial” was the subject of several Retraction Watch posts when it was retracted and then republished in a different form. And the conclusion of the new paper, in Bioscience, seemed likely to draw the ire of many who objected to the earlier work: Continue reading Caught Our Notice: Climate change leads to more…neurosurgery for polar bears?

Caught Our Notice: Duplicates, errors prompt two retractions for same author

Titles: 1) Angiopoietin-Like 4 Confers Resistance to Hypoxia/Serum Deprivation-Induced Apoptosis through PI3K/Akt and ERK1/2 Signaling Pathways in Mesenchymal Stem Cells

2) Novel Mechanism of Inhibition of Dendritic Cells Maturation by Mesenchymal Stem Cells via Interleukin-10 and the JAK1/STAT3 Signaling Pathway

What Caught Our Attention: In the span of 48 hours, PLOS ONE retracted two papers this month that were co-authored by Bo Yu, based at Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment and The Second Affiliated Hospital of Harbin Medical University in China. Both notices cite multiple duplications and errors, and conclude:

Continue reading Caught Our Notice: Duplicates, errors prompt two retractions for same author

Author: “The retractions were about bureaucracy, not science”

A researcher has retracted two 2014 papers, after discovering they had not gone through the proper approval process before being submitted.

The papers were part of a collaboration funded by the U.S. National Institutes of Health, which focused on solving protein structures. Adam Godzik, the senior author, told Retraction Watch that all papers had to be approved by a special committee before being submitted to a journal. Given the scale of the collaboration, the committee for the Joint Center for Structural Genomics (JCSG) would assess whether researchers who had made a previous contribution to the work should be added as authors.

Proteins: Structure, Function, and Bioinformatics retracted both papers after Godzik informed the editor in August 2014 that neither article had undergone the required review before being submitted to the journal. Although Wiley agreed to the retractions in an email to Godzik in September 2014,  the papers were only pulled in January—more than three years later. Continue reading Author: “The retractions were about bureaucracy, not science”

Caught Our Notice: “The first author cut the thermoprinter paper printout into pieces and reassembled them”

Title: A mitochondrial ferredoxin is essential for biogenesis of cellular iron-sulfur proteins

What Caught Our Attention: Here’s a cut-and-paste issue that gave us pause. The authors of an 18-year-old paper in PNAS corrected it after realizing some bands in a figure were duplicated (an issue raised on PubPeer one year ago). It turns out, the first author had cut the paper into pieces and reassembled them to present the blots in the “desired order,” and some had become duplicated by mistake. The overall results were unaffected, so the journal swapped the image with a corrected version. Continue reading Caught Our Notice: “The first author cut the thermoprinter paper printout into pieces and reassembled them”

Figures in cancer paper at root of newly failed compound called into question

How much role did a potentially problematic paper play in the demise of a once-promising compound?

Researchers are questioning the validity of a high-profile article, published by Nature in 2006. Although the letter is 12 years old, the concerns have current implications: It was among the early evidence used to develop a cancer compound that recently failed a number of clinical trials.

It’s unclear whether the problems with the paper — if validated — could have contributed to the compound’s demise. But an outside expert has some thoughts — and so do image experts and multiple external reports, including one released this month, which agree the concerns about the figures have merit. (The first author’s ex-husband isn’t too happy with the article, either.)

Continue reading Figures in cancer paper at root of newly failed compound called into question