Category: molecular biology

Retraction count for Shigeaki Kato climbs to 39

Shigeaki Kato
Shigeaki Kato

We’ve found another retraction for Shigeaki Kato, number seven on our leaderboard.

Our count for Kato has now risen to 39; we added five retraction notices to our count for Kato last month. These notices follow an investigation at the University of Tokyo, where Kato used to work, which found 43 papers contained “likely altered or forged materials,” according to a 2013 news article from The Asahi Shimbun.

Here’s the retraction note for “1alpha,25(OH)2D3-induced DNA methylation suppresses the human CYP271B1 gene,” published in Molecular and Cellular Endocrinology:

Continue reading Retraction count for Shigeaki Kato climbs to 39

Author dispute retracts paper suggesting NSAIDs curb growth in rats

jpedorthoThe corresponding author asked the Journal of Pediatric Orthopaedics to retract an article that found popular pain medicines can curb growth in rats, in light of an unresolved authorship dispute.

The article, “Nonsteroidal Anti-Inflammatory Drugs Cause Inhibition of the Growth Plate in Cultured Rat Metatarsal Bones,” details preliminary results that indicate nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce growth in rat bones in a dose-dependent manner, suggesting caution in treating chronic inflammatory diseases in children. The editor told us the paper was “highly rated” by reviewers and the results were “never in question,” but the senior author asked to pull the paper after failing to resolve a dispute with a researcher who asked to be added as an author.

According to the notice:  Continue reading Author dispute retracts paper suggesting NSAIDs curb growth in rats

JACS imaging paper “under editorial review” has been replicated, says author

JACS The author of a paper “under editorial review” at the Journal of the American Chemical Society has told us the results the paper have been replicated, contrary to claims made by a former member of her lab.

What’s more, the author said she has submitted a correction to the paper, which is currently flagged with an expression of concern, to provide uncropped images.

We originally reported on the case in February from the perspective of Roger Wong, a former chemist at Hong Kong University who said he hasn’t been able to replicate the findings out of the lab of Dan Yang, a current chemistry professor at HKU (who is female, despite the fact that “Dan” is frequently used as a male name in English). We unfortunately failed to reach Yang in February because of an email glitch; once we contacted Yang, she told us she does not believe Wong’s side of the story:

Continue reading JACS imaging paper “under editorial review” has been replicated, says author

Singapore investigation leads to another retraction, correction for Harvard research fellow

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After an investigation found evidence of misconduct, a biologist has issued a third retraction.

Sudarsanareddy Lokireddy — now a research fellow at Harvard Medical School — “admitted falsification,” a Research Integrity Officer at Nanyang Technological University in Singapore told us in December. According to The Scientist, another journal has also published a correction that the authors had requested earlier.

The newly retracted paper is “Myostatin is a novel tumoral factor that induces cancer cachexia,” published in Biochemical Journal and cited 40 times, according to Thomson Reuters Web of Science. Here’s the retraction note:

How did two papers on same gene with different authors, publishers, end up with identical retraction notices?

1-s2.0-S0006291X16X00058-cov150h1Here’s an interesting case: We’ve found two retracted papers that describe the same gene, and both have nearly identical retraction notices. What’s unusual is that the two papers don’t have any authors in common, and appeared in two different journals published by two different companies.

The cause of both papers’ demise: Plagiarism, and use of unpublished data without permission “from an unnamed source,” who wishes to remain that way. The author of one of the papers confirmed to us that the unnamed source is a “3rd party service company.” Springer told us that the third party in the other paper, however, is another researcher.

It’s a puzzling case, to be sure. We think we have uncovered some of what happened, but remain slightly fuzzy on the details.

Here’s the first retraction, for “KDM3A interacted with p53K372me1 and regulated p53 binding to PUMA in gastric cancer,” originally published online September 30 by Biochemical and Biophysical Research Communications:

Continue reading How did two papers on same gene with different authors, publishers, end up with identical retraction notices?

Mistakes lead to retraction, correction of cancer papers by pair

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A series of mistakes have caused a pair of cancer researchers based in China to retract one paper and correct another.

The retraction stems from a duplication of figures in a paper about the molecular underpinnings of colorectal cancer, which the editor of the journal told us he believed was caused by honest error. The other paper was corrected after the authors realized they had published the wrong versions of multiple figures, an error which the authors say does not affect the paper’s conclusions.

This isn’t the first time the pair has had to correct the record — these changes follow a mega-correction for Jie Hong, and Jing-Yuan Fang, both of the Shanghai Jiao-Tong University, where Fang is the director of the Shanghai Institute of Digestive Disease.

Here’s the retraction note for “Role of STAT3 and vitamin D receptor in EZH2-mediated invasion of human colorectal cancer,” published in the Journal of Pathology:

Continue reading Mistakes lead to retraction, correction of cancer papers by pair

Cell Press flags two papers after author confesses to fraud

Screen Shot 2016-04-11 at 8.45.56 PMNormally, when we see disputes over fraud allegations, it’s one author accusing another — but an unusual case at Cell has recently crossed our desk.

The journal has flagged a paper after an author confessed to committing fraud himself — but the corresponding author is disputing that confession, citing concerns about the confessor’s “motives and credibility.”

Independent labs are repeating the experiments to determine if the third author on the paper did, as he so claims, manipulate experiments. In the meantime, Cell and Molecular Cell have issued expressions of concern (EOCs) for two papers on which Yao-Yun Liang was a co-author. The notices cite an inquiry at Baylor College of Medicine, where the work was done, which was inconclusive, and recommended the journals take no action about the papers.

The EOCs are pretty much the same (both journals are published by Cell Press). Here’s the EOC that appears on “PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling,” published in 2006 by Cell and cited 251 times, according to Thomson Reuters Web of Science:

Continue reading Cell Press flags two papers after author confesses to fraud

Seven papers flagged earlier for fake reviews now retracted by Elsevier

elsevierElsevier has now retracted the seven papers it flagged in October as being affected by fake peer reviews.

If you’re not keeping track, we are: We have logged a total of about 300 retractions for fake peer review, in which some aspect of the peer-review process becomes compromised — for instance, in the case of the newly retracted papers, authors appear to have created fake email accounts in order to pose as reviewers and give the green light to their own papers.

The same retraction note applies to five of the recently retracted papers:

Continue reading Seven papers flagged earlier for fake reviews now retracted by Elsevier

Image splicing, duplications, inversions kill paper for well-known longevity researcher and alum of lab

Gizem Domnez
Gizem Donmez

A well-known scientist at the Massachusetts Institute of Technology who studies longevity has retracted a paper for “numerous examples of unindicated splicing of gel lanes,” as well as other problems.

This is Leonard Guarente‘s second retraction. He shares both with Gizem Donmez, an alum of his lab who now has three retractions. Donmez left her post as a Tufts professor in 2014.

Guarente told us in March — when we reported that he’d published a mega-correction on another paper — that he had planned to address issues with the paper, “SIRT1 Protects against α-Synuclein Aggregation by Activating Molecular Chaperones,” published in the The Journal of Neuroscience. Now, a retraction note has appeared “at the request of the authors.” It explains:

Continue reading Image splicing, duplications, inversions kill paper for well-known longevity researcher and alum of lab

Does this scientific image look familiar? It’s from a catalog

cover (4)There’s something strange about a 2008 paper on the role of nicotine receptors in promoting lung cancer: One of the western blot analyses looks like a version of an image from a commercial catalog.

A commenter on PubPeer pointed out the similarities between an image in “Role of α7-nicotinic acetylcholine receptor in human non-small cell lung cancer proliferation,” which was published in Cell Proliferation, and one used to promote an enzyme sold by Cell Signaling Technology.

Unfortunately, if the images are indeed the same, we can’t tell for certain who copied from whom. But a representative of the company told us it generates its own images, and this one was likely created before the paper was published. The last author — for whom we’ve found three other retractions — denied that the paper copied the image.

Here’s the panel from the paper, which was published in 2008: Continue reading Does this scientific image look familiar? It’s from a catalog