Category: molecular biology

Third party company botched student’s doctoral work, says biologist

Cellular Physiology and BiochemistryA PhD student who was supposed to complete part of an experiment passed the job on to a third party company, which in turn provided figures that were plagiarized and fabricated. That’s according to the corresponding author of the paper, which has now been retracted.

Hong Ren, affiliated with Xi’an Jiao Tong University in China, told us that he decided to delay the student’s graduation after he discovered that the student had passed off the work.

It’s not at all obvious that a third party was involved from the brief retraction notice for “EMT phenotype is induced by increased Src kinase activity via Src-mediated caspase-8 phosphorylation:”

Continue reading Third party company botched student’s doctoral work, says biologist

Images that raised eyebrows flagged by another journal; Malaysian gov’t investigates

Screen Shot 2016-06-15 at 9.17.15 AMMultiple investigations have been launched into allegations of blatant duplications by a research group in Malaysia.

Last week, users alleged on Twitter that three papers by the same team included pictures of cells that were copied and pasted. First author Nima Samie, affiliated with University of Malaya in Malaysia, denied the accusations — but both the Malaysian government and now two journals sees cause for further investigation.

Frontiers in Pharmacology published an expression of concern this morning:

Continue reading Images that raised eyebrows flagged by another journal; Malaysian gov’t investigates

Misidentified cell line fells cancer paper

Screen Shot 2016-04-15 at 2.52.06 PMResearchers have retracted a paper about a new molecular target for cancer after realizing they had mistaken the identity of their cell line.

It’s all too easy to mix up cell lines, so we see plenty of retractions for that reason — and, according to an expert in the area, many more cases lurk uncorrected in the literature.

The retraction notice for “Knockdown of tumor protein D52-like 2 induces cell growth inhibition and apoptosis in oral squamous cell carcinoma” in Cell Biology International explains the authors’ perspective on this case:

Continue reading Misidentified cell line fells cancer paper

PLOS ONE retracts 2 malaria papers over doubts experiments ever took place

PLOS One

Authors have retracted a pair of PLOS ONE papers after an investigation suggested the articles might contain some fiction.

In the papers, the authors describe collecting and analyzing the DNA of mosquitoes to look for changes following the introduction of bed nets treated with insecticides to combat malaria. However, an investigation by the Institut de Recherche pour le Développement in France could not confirm some of the experiments ever took place.

Here’s the retraction notice for “How the Malaria Vector Anopheles gambiae Adapts to the Use of Insecticide-Treated Nets by African Populations,” which appears at the top of the paper:

Continue reading PLOS ONE retracts 2 malaria papers over doubts experiments ever took place

Authors reused images in three papers, concludes journal probe

JBCBiologists are retracting three papers after the journal concluded they contain reused images, designed to represent different experiments. The authors stand by the conclusions, some of which they say have been “extensively validated.”

The Journal of Biological Chemistry used image analysis software to evaluate the images, first published at least a decade ago. Unfortunately, the raw data behind the problematic images were not available. The authors have also corrected a fourth paper in another journal, and wrote on PubPeer that they are working with journals to address concerns in three more.

The papers share two authors: Mireia Duñach at the Autonomous University of Barcelona, and Antonio García de Herreros at the Institut Hospital del Mar d’Investigacions Mèdiques. A representative of the Institut Hospital del Mar d’Investigacions Mèdiques told us it is looking into Garcia de Herreros’s work.

We’ll start with “β-Catenin N- and C-terminal tails modulate the coordinated binding of adherens junction proteins to β-catenin,” which has been cited 45 times since it was published in 2002, according to Thomson Reuters Web of Science. The retraction notice says:

Continue reading Authors reused images in three papers, concludes journal probe

JACS corrects, removes author from previously flagged paper

JACSA paper at the center of a high-profile case of alleged misconduct in Hong Kong has earned a correction notice.

The correction replaces an expression of concern on the Journal of the American Chemical Society (JACS) paper, which followed allegations of data manipulation. It provides some un-cropped images, and removes a co-author from the paper. However, it does not appear to address previous allegations of misconduct, nor a recent ruling from an investigation at Hong Kong University (HKU), which found that some of the data were “invalid.”

Here is the correction notice for “Molecular Imaging of Peroxynitrite with HKGreen-4 in Live Cells and Tissues:”

Continue reading JACS corrects, removes author from previously flagged paper

Cancer researchers: We took data from another lab

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Authors have admitted to using material from another lab for their paper on neuroblastoma.

A spokesperson for Springer told us that the theft came to light when:

The scientists, from whom the data originated, contacted the journal.

The editor in chief of the journal investigated the case, the spokesperson told us, and then issued this retraction notice:

Continue reading Cancer researchers: We took data from another lab

Neuroscientist forged co-author’s signature, submitted paper without consent

European Journal of Neuroscience cover2The European Journal of Neuroscience has pulled a paper after learning that one author’s name had been included without his consent.

Co-editor-in-chief of the journal, Paul Bolam, told us that the Shandong University of Medicine in China (where the work was carried out) conducted an investigation and found “a serious case of academic misconduct” — one author had forged the signature of another researcher, in order to add him as a co-author on a project in which he had not participated.

Here’s the retraction notice, which tells us a bit more: Continue reading Neuroscientist forged co-author’s signature, submitted paper without consent

Authors retract non-reproducible Cell paper

CellAuthors have retracted a paper from Cell after they were unable to reproduce data in two figures, compromising their confidence in some of the findings.

The authors revisited their experiments after another lab was unable to replicate their data, about proteins that may play a role in lung cancer.

The first author told Nature News in 2013 that the paper may have helped her secure her current position at the Novartis Institutes for Biomedical Research in Massachusetts.

Pulling “Cytohesins are cytoplasmic ErbB receptor activators” appears to be a case of doing the right thing, given the detailed retraction notice:

Continue reading Authors retract non-reproducible Cell paper

Doing the right thing: Authors share data, retract when colleague finds error

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A pair of chemical engineers has retracted a paper after another researcher was unable to replicate their work, in a case that we consider an example of doing the right thing.

Dennis Prieve, at Carnegie Mellon University, was interested in applying the paper — on how systems of molecules known as “reverse micelles” conduct electrical charge — to his own work, but was having trouble repeating the calculations. So Prieve contacted the authors — John Berg and his PhD student Edward Michor, based at the University of Washington — who supplied him with their original data.

It took several weeks of back and forth to figure out the problem, Michor told us, as the paper was published in 2012, so he had to decipher his old notes. When they found that several incorrect values were used in the paper, the authors issued a retraction notice, published in March:

Continue reading Doing the right thing: Authors share data, retract when colleague finds error