Key assertions in a paper on homosexuality have been removed from the Journal of the Islamic Medical Association of North America, in what the notice describes as a “partial retraction.”
The 2006 article “Homosexuality: An Islamic Perspective,” states that conversion therapy can be effective, and that gay people have poorer health. Those statements are among those that lack evidence, according to a note on the paper published in July. The retraction pulls those assertions, among others, and instead argues that a homosexual person should be helped to “accept his or her LGB identity,” and find a welcoming community.
The 2006 article is definitely a perspective — it states the opinion of the sole author, M. Basheer Ahmed, who has a private psychiatry practice in Texas, as to whether homosexuality is a choice. He thinks yes, though the science on the matter is fairly clear that it’s not.
A JAMA study on an inexpensive treatment for osteoporosis has been retracted because the first author falsified or fabricated data. We’ve been expecting this one: An investigation at Women’s College Hospital in Toronto, the bone researcher’s former workplace, had already revealed issues with the paper.
An internal memo sent to staff (available in full here) in October explained that the investigation had found “unequivocal evidence of systematic data manipulation” by Sophie Jamal, who had already resigned from her positions at WCH and the University of Toronto.
The study appeared to show that nitroglycerin ointment could have a small positive effect on bone mineral density in postmenopausal patients. It’s been cited 30 times, according to Thomson Scientific’s web of Knowledge. (That’s two more times than when we last reported on the paper: It was cited once by the investigation, and once by a paper that was published earlier in October, but had not yet been indexed.)
Researchers in Germany have retracted their 2011 article in the Journal of Bacteriology after another lab pointed out a fatal error in the paper.
The article, “Escherichia coli Exports Cyclic AMP via TolC,” came from a group at Tübingen University led by Klaus Hantke. The paper focuses on the crucial role of the membrane channel TolC in exporting cyclic AMP (cAMP)-cAMP receptor protein (CRP) complex, which regulates nearly 200 E. coli genes. According to the abstract:
The data demonstrate that export of cAMP via TolC is a most efficient way of E. coli to lower high concentrations of cAMP in the cell and maintain its sensitivity in changing metabolic environments.
If you could help reduce the waste of tens of billions of dollars per year in research spending, you’d do it, right?
This is the second in a series of two guest posts about the havoc misidentified cell lines can wreak on research, from Leonard P. Freedman, president of the Global Biological Standards Institute. Freedman who published a paper last summer detailing the financial costs of non-reproducible research — namely, tens of billions of dollars per year. Some of that non-reproducible research is due to the use of contaminated or misidentified cell lines. He writes about one key step to tackling the problem: Ask every scientist to use a relatively inexpensive technique to validate the identity of their cell lines.
Meanwhile, we have to deal with the issue of all the previously published papers that relied on problematic cell lines, now contaminating the scientific literature. Scroll down to the bottom of the post to take a poll on what you think should be done about those papers.
Leonard Freedman
As new frontiers of science emerge, from Pluto to proteins, the very cornerstone of the scientific process—reproducibility—has also reared its head as a huge problem. Estimates of irreproducibility rates of published peer-reviewed papers range from 51% to 89%. An analysis that two colleagues and I recently published in PLOS Biology suggests the U.S. spends $28 billion per year on non-reproducible preclinical research; global spending could be up to $60 billion per year. This lack of reproducibility typically results from cumulative errors or flaws in one or more of the following areas: biological reagents and reference materials, study design, laboratory protocols, and data analysis and reporting. Given the size, scale, and especially the complexity of reproducing preclinical research, there is no single magic bullet fix. This is a difficult issue for scientists to own up to, and for the public to grasp.
What if we told you that approximately 1 in 6 researchers working with human cells are using the wrong cell line? In other words, they believe they are studying the effects of a drug on breast cancer cells, for instance, but what they really have are cells from the bladder. That is the unfortunate reality in life science research today, affecting hundreds of labs. It’s a major source of problematic papers which cannot be replicated, wasting scientists’ time and funding.
We’re pleased to present a guest post from Amanda Capes-Davis, chair of the International Cell Line Authentication Committee (ICLAC), a voluntary scientific committee created to improve awareness of misidentified cell lines. She also collects news about cell line and culture contamination. This is the first in a series of two posts from guest authors about how problematic cell lines are contaminating the scientific literature, and how we can clean it up.
In 2010, I worked alongside Ian Freshney of Glasgow University and other colleagues to publish a list of cross-contaminated or otherwise misidentified cell lines in the International Journal of Cancer. This database of false cell lines is now curated by the International Cell Line Authentication Committee (ICLAC).
A paper suggesting that exposure to sunlight might help prevent hip fractures in the elderly has been retracted, due to duplication and “concerns about the underlying data.”
An expression of concern that appeared last July flagged the 2005 paper as containing text that matched another paper with the same first author that was published in 2011. According to the publisher, that duplicated text sparked a closer look at the text, which raised concerns about the scientific integrity of the paper.
An investigation at the Queensland University of Technology in Australia has found that a paper on air pollution and human health contains a host of issues with the data and its analysis. The paper has been retracted with a very detailed note from Environmental Research.
The issues with the paper include an “incorrect analysis of the data,” and its failure to properly cite multiple papers and one researcher’s contributions. Ultimately, according to the retraction note, the investigation found that the “conclusions of the paper are flawed.”
“Submicrometer particles and their effects on the association between air temperature and mortality in Brisbane, Australia” has been cited three times, according to Thomson Scientific’s Web of Knowledge.
The retraction note is very, very detailed. It outlines the problems with the paper:
An incorrect proof has felled a math paper. There’s not too much to say in a straightforward situation like this one, which we’ve seen before — the result of honest errors, not any malfeasance.
In this paper, we give an affirmative answer to Mbekhta’s conjecture (Mbekhta, 1990) about the pseudo Fredholm operators in Hilbert space. As a consequence, we characterize pseudo Fredholm operators and we prove that the generalized Kato spectrum satisfies the spectral mapping theorem in the Hilbert spaces setting.
The paper — published in the Journal of Mathematical Analysis and Applications — has been cited twice, according to Thomson Scientific’s Web of Knowledge.
The investigation, by the Istituto Nazionale per la Ricerca sul Cancro, found that there were multiple “figure anomalies.” According to the note:
An explanation of inadvertent error was given for some of the issues identified, while for two issues, a satisfactory explanation could not be provided.
First author Roberto Gherzi says none of his co-authors helped prepare the figures. The authors maintain that the conclusions are unaffected, but that assurance wasn’t enough for the journal. Here’s more from the lengthy retraction note, which provides some backstory on the “serious concerns” regarding the data:
A study that found a 15-fold increase in the rate of sexual trauma among men in the U.S. military — and sparked suggestions of “an epidemic of male-on-male sex crimes” in the military among conservative media outlets — has been retracted because of a flaw in the analysis.
