A once-lauded researcher in the field of infectious disease — who has since been found guilty of misconduct — has retracted a second paper.
Last year, the University of Dundee in Scotland investigated and ultimately concluded that Robert Ryan — whose work focused on infections that can be deadly in people with lung diseases such as cystic fibrosis — had committed “serious research misconduct,” affecting multiple publications. After appealing the decision, Ryan resigned.
We covered his first retraction earlier this month, which cited multiple instances of image duplication. Now Ryan has retracted his second paper, published in 2011 in Journal of Bacteriology, also due to image problems.
Researchers in Germany have retracted their 2011 article in the Journal of Bacteriology after another lab pointed out a fatal error in the paper.
The article, “Escherichia coli Exports Cyclic AMP via TolC,” came from a group at Tübingen University led by Klaus Hantke. The paper focuses on the crucial role of the membrane channel TolC in exporting cyclic AMP (cAMP)-cAMP receptor protein (CRP) complex, which regulates nearly 200 E. coli genes. According to the abstract:
The data demonstrate that export of cAMP via TolC is a most efficient way of E. coli to lower high concentrations of cAMP in the cell and maintain its sensitivity in changing metabolic environments.
Before her death in January 2006, of a brain tumor, Hasson and her husband, David Sanders, made up a power-team of protein researchers at Purdue.
Hasson was an X-ray crystallographer while Sanders is a biochemist, and together they would map out the structure and function of proteins. One of their projects was a collaboration funded by a grant to Sanders from the National Science Foundation. By the time Diao joined, the effort had already led to butyrate-kinase crystals — albeit of poor quality, Sanders said.