Category: mega-corrections

Cancer Cell issues big correction over “incorrectly cropped” figures, other issues

cancer cell A 2014 Cancer Cell paper became the subject of an erratum in January 2015, shortly after PubPeer members began criticizing the data. However, many issues brought up by commenters weren’t addressed in the correction notice, including a figure that might be two experiments spliced together to look like one.

The paper, led by Guido Franzoso at Imperial College London, claims that a new cancer drug called DTP3 kills myeloma cells “without causing any toxic side effects,” according to a press release from the school. Guido Franzoso is the founder of Kesios Therapeutics, a drug company which is set to begin clinical trials on DTP3.

The correction indicates that Western blots were cropped badly, which omitted several panels discussed in the text, while an “extra time point” was included accidentally. An antibody was also omitted from the description of the procedure.

PubPeer commenters have noticed additional issues, such as a criticism of figure 3D, which were not included or changed in this correction.

Here’s the correction for “Cancer-Selective Targeting of the NF-κB Survival Pathway with GADD45β/MKK7 Inhibitors”: Continue reading Cancer Cell issues big correction over “incorrectly cropped” figures, other issues

Drug paper gets a fix, notching several corrections

rsc_tb_1_3_COVER.inddThe Journal of Materials Chemistry B has issued a laundry list of corrections for a 2014 chemotherapy paper, which address re-use of “some text”, incorrectly stated doses, and miscalculations of the drug concentration, among other issues.

The paper described a new way to deliver gemcitabine via nanoparticles, focusing the drug on the tumors.

It turns out the authors’ focus wasn’t so clear when writing the paper. The researchers, at the Chinese Academy of Medical Science, Peking Union Medical College, and Tianjin University in China, said they used “some text” from two 2013 papers by a team of French oncologists “without appropriate attribution,” as well as repeatedly getting the in vivo dose wrong. The manuscript also contained several incorrect calculations of the “drug loading,” or the proportion of active drug.

Here’s the correction for “Tailor-made gemcitabine prodrug nanoparticles from well-defined drug–polymer amphiphiles prepared by controlled living radical polymerization for cancer chemotherapy” (free, but requires sign-in): Continue reading Drug paper gets a fix, notching several corrections

U. Illinois chancellor earns mega-correction for duplicate publication

Phyllis Wise, from University of Illinois
Phyllis Wise, via University of Illinois

Phyllis Wise, the chancellor of the University of Illinois and an obstetrics researcher, has called for a massive correction of a 2006 paper in Neuroscience for work she appears to have tried to pass off as having been previously unpublished — but which wasn’t.

The article, “Estrogen therapy: Does it help or hurt the adult and aging brain? Insights derived from animal models,” has been cited 47 times, according to Thomson Scientific’s Web of Knowledge.

And it had caught also the attention of readers on PubPeer, who noted that: Continue reading U. Illinois chancellor earns mega-correction for duplicate publication

Hepatology issues corrections in two papers from Pitt liver group

hepatology A group of liver researchers from the University of Pittsburgh has earned a pair of corrections in Hepatology for image problems.

The team was led by George K. Michalopoulos, chair of the department of pathology at the University of Pittsburgh Medical Center.

One article, “Excessive hepatomegaly of mice with hepatocyte-targeted elimination of integrin linked kinase following treatment with 1,4-bis [2-(3,5-dichaloropyridyloxy)] benzene,” appeared in January 2011. According to the notice: Continue reading Hepatology issues corrections in two papers from Pitt liver group

Mega-correction appears for Florida leadership scholar Walumbwa following six retractions

Fred Walumbwa, via FIU
Fred Walumbwa, via FIU

Fred Walumbwa, the leadership researcher at Florida International University who has retracted six papers for what appear to be problematic data, now has an impressive mega-correction in the form of an “addendum.”

The paper, “Relationships between Authentic Leadership, Moral Courage, and Ethical and Pro-Social Behaviors,” was published in Business Ethics Quarterly in October 2011, by Walumbwa and two colleagues, Sean Hannah and Bruce Avolio.

Here’s the abstract for the paper, which has been cited 18 times, according to Thomson Scientific’s Web of Knowledge:

Continue reading Mega-correction appears for Florida leadership scholar Walumbwa following six retractions

Nature corrects a correction

nature 4 9 14Last year, we reported on a Nature correction of a paper for what a McGill University committee had earlier called “intentionally contrived and falsified” figures. It turns out that the correction — like the original paper — left some Nature readers puzzled, so the journal has run a correction of the correction: Continue reading Nature corrects a correction

Authors of “just make up an…analysis” Organometallics paper issue mega-correction

organometallicscoverBack in August we — and others — wrote about a paper in Organometallics for which one member of the study team appeared to have instructed a co-author to pad the article with artificial results. From the supplemental information (SI) of that paper:

Emma, please insert NMR data here! where are they? and for this compound, just make up an elemental analysis…

Now comes a correction statement from the group that can only be described as “mega.” First reported last month by Chemical & Engineering News, the lengthy notice begins: Continue reading Authors of “just make up an…analysis” Organometallics paper issue mega-correction

Nature yanks controversial genetics paper whose co-author was found dead in lab in 2012

naturecover1113Nature has retracted a controversial 2012 paper by a group from Johns Hopkins University which has been the subject of a protracted public dispute.

The article, “Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK,” came from the lab of Jef Boeke,  a celebrated biochemist. But a former lab member, Daniel Yuan, who was fired by Hopkins in late 2011 after 10 years at the institution, had repeatedly raised questions about the validity of the findings. Those concerns eventually made their way into the Washington Post, prompting this response from the university. Continue reading Nature yanks controversial genetics paper whose co-author was found dead in lab in 2012

JBC issues correction for paper by Khachigian, who has had four others retracted

jbc1113The Journal of Biological Chemistry has a fairly gory correction — we’d call it a mega-correction — for a 2010 paper by Levon Khachigian, an Australian researcher whose studies of a new drug for skin cancer recently were halted over concerns about possible misconduct, including image manipulation. As we reported earlier this year, Khachigian has already lost four papers, including one in the JBC — which the journal simply noted had “been withdrawn by the authors.”

The new correction involves the article “c-Jun regulates shear- and injury-inducible Egr-1 expression, vein graft stenosis after autologous end-to-side transplantation in rabbits, and intimal hyperplasia in human saphenous veins,” which Khachigian wrote with Jun Ni and Alla Waldman. The paper has been cited nine times, according to Thomson Scientific’s Web of Knowledge. Here’s the notice: Continue reading JBC issues correction for paper by Khachigian, who has had four others retracted

A Cancer Cell mega-correction for highly cited researcher who retracted paper earlier this year

cancer cell 9-13MIT’s Robert Weinberg, a leading cancer researcher who retracted a Cancer Cell paper earlier this year for “inappropriate presentation” of figures, has corrected a different paper in the same journal.

Here’s the correction for “Species- and Cell Type-Specific Requirements for Cellular Transformation:”

We were apprised recently of errors made in the assembly of Figures 2B, 3A, 4A, 4B, and 5G, resulting in the incorporation of incorrect representative images in these figures. These errors occurred during the electronic assembly and have no bearing on the conclusions of the study. The corrected figures are shown below. The authors apologize for any possible confusion this might have caused.

Here’s the original Figure 2 and caption, followed by the new version (read all the way to the end of the post for more details on how this came to light): Continue reading A Cancer Cell mega-correction for highly cited researcher who retracted paper earlier this year