Category: image manipulation

JCI retracts paper by stem cell biologist Jacob Hanna, citing “figure irregularities”

jciapril2015The Journal of Clinical Investigation has retracted a 2004 paper by Jacob Hanna, a highly cited stem cell researcher in Israel whose work has been dogged by questions about its validity.

Questions about the work, and other articles on which Hanna was an author, were raised on PubPeer last November. This is his first retraction.

The retraction stems from “a number of figure irregularities;” the authors say they were “inadvertently introduced,” and subsequent work has supported their data and conclusions. However, due to the “number of serious mistakes,” the JCI editorial board chose to retract the article. Hanna and corresponding author Ofer Mandelboim at The Lautenberg Center for General and Tumor Immunology — part of Hebrew University, in Jerusalem, where Hanna used to work — say they have accepted the decision.

Hanna, currently at the Weizmann Institute of Science, studies ways to reprogram cells to become more versatile stem cells. He also spent time as a postdoc at the Whitehead Institute in Cambridge and Mount Sinai, in New York City.

Six of Hanna’s papers have been cited more than 500 times, according to Thomson Scientific’s Web of Knowledge. The most-cited, with more than 1,000 citations, was a 2008 Nature paper.

The retracted article, “Novel APC-like properties of human NK cells directly regulate T cell activation,” has been cited 121 times, according to Thomson Scientific’s Web of Knowledge.

The retracted paper examined the early steps of an immune response involving natural killer (NK) cells and antigen-presenting cells (APCs). From the abstract: Continue reading JCI retracts paper by stem cell biologist Jacob Hanna, citing “figure irregularities”

Wayne State neuroscientist fudged images in five papers

Teresita L. Briones
Teresita L. Briones

Teresita Briones, a former nursing professor at Wayne State University in Detroit who studied neuroscience, manipulated images in five papers, according to the Office of Research Integrity.

Briones, who focused on neuroplasticity: Continue reading Wayne State neuroscientist fudged images in five papers

Former Columbia postdoc faked Alzheimer’s research in Cell and Nature

cover_natureRyousuke Fujita, a former Columbia University postdoc who admitted to having faked the findings of a 2011 Cell paper in a retraction notice last year, also faked the results of a 2013 Nature paper, according to a new report from the Office of Research Integrity (ORI).

Fujita’s work, in conjunction with Asa Abeliovich, was widely hailed as a significant step forward, a way to turn skin cells into brain cells. But the story began falling apart when the Cell retraction said that he “acknowledged inappropriately manipulating image panels and data points, as well as misrepresenting the number of repeats performed.”

The ORI’s findings in the case also involve a 2013 Nature paper, “Integrative genomics identifies APOE ε4 effectors in Alzheimer’s disease,” and a paper never published. Fujita, according to the ORI: Continue reading Former Columbia postdoc faked Alzheimer’s research in Cell and Nature

Retraction to appear for beleaguered plant researcher Olivier Voinnet

Olivier Voinnet
Olivier Voinnet

Olivier Voinnet, a researcher at ETH in Zurich who has corrected a number of his papers following critiques on PubPeer dating from late last year, is retracting a 2004 paper in The Plant Cell, according to the journal’s publisher.

Voinnet, the winner of the 2013 Rössler Prize, is a high-profile scientist, and scrutiny of his work has only grown since the initial revelations. In an unusual move, the journal and its publisher, the American Society of Plant Biologists, put out a press release about the situation today. Here’s the statement: Continue reading Retraction to appear for beleaguered plant researcher Olivier Voinnet

Cancer researcher under investigation in Italy notches eighth retraction

ejcancerAlfredo Fusco, the researcher in Italy who is under criminal investigation and has had seven papers retracted, has lost yet another study.

The investigation, which came to light in late 2013, had focused on eight papers thought to demonstrate evidence of image manipulation.

The latest paper, in the European Journal of Cancer, studied mice with a genetic alteration associated with lipomas (benign fatty growths) in humans.

Here’s part of the notice for “Expression of a truncated Hmga1b gene induces gigantism, lipomatosis and B-cell lymphomas in mice”: Continue reading Cancer researcher under investigation in Italy notches eighth retraction

Other shoe drops for MIT cancer researcher Robert Weinberg as Cell retraction appears

cell cloningRobert Weinberg, a prominent cancer scientist whose papers often notch hundreds or thousands of citations, has lost a fourth paper, this time a 2009 publication in Cell.

Journal Genes and Development pulled two of Weinberg’s papers in March, stating that they had retracted the 2009 study because data from several experiments was used in figures that seemed to represent only one. The Genes and Development papers were sunk because the “same analytical methodology was used.”

At the time, the Cell retraction was unavailable, though a spokesperson informed us it was forthcoming. The paper has been cited 482 times, according to Thomson Scientific’s Web of Knowledge.

Now that the notice has landed, here’s why the paper is being retracted: Continue reading Other shoe drops for MIT cancer researcher Robert Weinberg as Cell retraction appears

Cancer Cell issues big correction over “incorrectly cropped” figures, other issues

cancer cell A 2014 Cancer Cell paper became the subject of an erratum in January 2015, shortly after PubPeer members began criticizing the data. However, many issues brought up by commenters weren’t addressed in the correction notice, including a figure that might be two experiments spliced together to look like one.

The paper, led by Guido Franzoso at Imperial College London, claims that a new cancer drug called DTP3 kills myeloma cells “without causing any toxic side effects,” according to a press release from the school. Guido Franzoso is the founder of Kesios Therapeutics, a drug company which is set to begin clinical trials on DTP3.

The correction indicates that Western blots were cropped badly, which omitted several panels discussed in the text, while an “extra time point” was included accidentally. An antibody was also omitted from the description of the procedure.

PubPeer commenters have noticed additional issues, such as a criticism of figure 3D, which were not included or changed in this correction.

Here’s the correction for “Cancer-Selective Targeting of the NF-κB Survival Pathway with GADD45β/MKK7 Inhibitors”: Continue reading Cancer Cell issues big correction over “incorrectly cropped” figures, other issues

Drug paper gets a fix, notching several corrections

rsc_tb_1_3_COVER.inddThe Journal of Materials Chemistry B has issued a laundry list of corrections for a 2014 chemotherapy paper, which address re-use of “some text”, incorrectly stated doses, and miscalculations of the drug concentration, among other issues.

The paper described a new way to deliver gemcitabine via nanoparticles, focusing the drug on the tumors.

It turns out the authors’ focus wasn’t so clear when writing the paper. The researchers, at the Chinese Academy of Medical Science, Peking Union Medical College, and Tianjin University in China, said they used “some text” from two 2013 papers by a team of French oncologists “without appropriate attribution,” as well as repeatedly getting the in vivo dose wrong. The manuscript also contained several incorrect calculations of the “drug loading,” or the proportion of active drug.

Here’s the correction for “Tailor-made gemcitabine prodrug nanoparticles from well-defined drug–polymer amphiphiles prepared by controlled living radical polymerization for cancer chemotherapy” (free, but requires sign-in): Continue reading Drug paper gets a fix, notching several corrections

Nothing gold can stay: gold nanoparticle paper retracted for figure theft

matresexpA paper on gold nanoparticles has been retracted after the publisher learned one of the figures had a “high degree of similarity” to a figure published by other authors a few months prior.

According to the notice, it was two authors of the retracted paper themselves who pointed out the overlap. The first author, Pratap Sahoo, is not mentioned, although it does say all three authors agreed to retract. The corresponding author of the original paper told us he was unaware of the incident.

You can compare the figures for yourself – on the left is figure 6(a) from the retracted Materials Research Express paper, rotated 90 degrees. On the right is figure 4(e) from “Porous Au Nanoparticles with Tunable Plasmon Resonances and Intense Field Enhancements for Single-Particle SERS,” published in the Journal of Physical Chemistry Letters: Continue reading Nothing gold can stay: gold nanoparticle paper retracted for figure theft

“Not faithful” figures kill apoptosis paper

iaicoverA paper on apoptosis in mice has been retracted by Infection and Immunity after a reader tipped them off that several figures were “not faithful representations of the original data.”

When the journal, published by the American Society for Microbiology (ASM), contacted the authors at Anhui Medical University in Hefei, China, they claimed they couldn’t provide the experimental data thanks to “damage to a personal computer,” said Ferric Fang, editor of the journal and a member of the board of directors of the Center for Scientific Integrity, Retraction Watch’s parent organization. Seven figures in total were compromised, including several that were duplicated throughout the article.

Here’s the notice for “Reactive Oxygen Species-Triggered Trophoblast Apoptosis Is Initiated by Endoplasmic Reticulum Stress via Activation of Caspase-12, CHOP, and the JNK Pathway in Toxoplasma gondii Infection in Mice”: Continue reading “Not faithful” figures kill apoptosis paper