Category: erroneous data

Authors retract, replace highly cited JAMA Psych paper for “pervasive errors”

JAMA PsychiatryAuthors have retracted a highly cited JAMA Psychiatry study about depression after failing to account for some patient recoveries, among other mistakes.

It’s a somewhat unusual notice — it explains that the paper has been retracted and replaced with a new, corrected version.

The study, which included 452 adults with major depressive disorder, concluded that cognitive therapy plus medication works better to treat depression than pills alone. But after it was published, a reader pointed out that some of the numbers in a table were incorrect. The authors reviewed the data and redid their analysis, and discovered “a number of pervasive errors.”

The notice (termed “notice of retraction and replacement”) explains the consequences of those errors:

Continue reading Authors retract, replace highly cited JAMA Psych paper for “pervasive errors”

Mistakes lead to retraction, correction of cancer papers by pair

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A series of mistakes have caused a pair of cancer researchers based in China to retract one paper and correct another.

The retraction stems from a duplication of figures in a paper about the molecular underpinnings of colorectal cancer, which the editor of the journal told us he believed was caused by honest error. The other paper was corrected after the authors realized they had published the wrong versions of multiple figures, an error which the authors say does not affect the paper’s conclusions.

This isn’t the first time the pair has had to correct the record — these changes follow a mega-correction for Jie Hong, and Jing-Yuan Fang, both of the Shanghai Jiao-Tong University, where Fang is the director of the Shanghai Institute of Digestive Disease.

Here’s the retraction note for “Role of STAT3 and vitamin D receptor in EZH2-mediated invasion of human colorectal cancer,” published in the Journal of Pathology:

Continue reading Mistakes lead to retraction, correction of cancer papers by pair

Plant scientist Voinnet’s correction count grows to 22

nature structure molecular biologyWe have found another correction for high-profile plant scientist Olivier Voinnet, bringing his total count to 22. Voinnet, who works at ETH Zurich, also has seven retractions, a funding ban, and a revoked award.

Voinnet’s most recent corrections involve problems with figures; the same issue is cited in this latest correction notice, for “Competition for XPO5 binding between Dicer mRNA, pre-miRNA and viral RNA regulates human Dicer levels.”

The correction notice in Nature Structural & Molecular Biology, issued earlier this year, explains:

Continue reading Plant scientist Voinnet’s correction count grows to 22

Three HER2-cancer review papers tagged with expressions of concern

The Oncologist Her 2 expression of concern

The Oncologist has tagged three review papers that share a first author with an expression of concern. The three papers, which have together been cited more than 1,000 times, focus on HER2, a gene that can contribute to breast cancer.

Though the papers contain errors, the conclusions — about how the HER2 gene serves as a predictive factor for breast cancer, and a target for therapies — remain unchanged, according to the EOC. The editor of the journal notes that the conclusions of the papers have been confirmed by other publications. Two of the papers are more than 10 years old, and today many patients continue to be treated with medications that target HER2, such as Herceptin.

Here’s the expression of concern:

Continue reading Three HER2-cancer review papers tagged with expressions of concern

Physicists retract Nature paper on Earth’s core after findings aren’t reproducible

cover_naturePhysicists have retracted a highly cited paper from Nature on the behavior of electrons at the center of the Earth after other researchers could not reproduce their findings.

The 2015 paper earned coverage in Science News and Live Science, where co-author Ronald Cohen explained:

There was a big problem in how you generate a magnetic field, and now, because of our results, that problem has basically gone away.

Here are more details about what the original paper claimed, courtesy of a press release from The Carnegie Institution for Science, where co-authors Peng Zhang and Cohen work: Continue reading Physicists retract Nature paper on Earth’s core after findings aren’t reproducible

Paper on GI cancers linked to AIDS pulled for errors that upped tumor incidence

gastroGastroenterology has retracted a 2012 article on GI cancers associated with AIDS after the authors, from the National Cancer Institute, acknowledged that a “programming” error led them to overestimate the incidence of the tumors.

The paper, “Increased Risk of Stomach and Esophageal Malignancies in People With AIDS,” received a significant amount of attention when it first appeared, including a press release from the American Gastroenterological Association and several news articles. Here are its primary findings, according to the abstract:  Continue reading Paper on GI cancers linked to AIDS pulled for errors that upped tumor incidence

Son sees dead father in case report, requests retraction

ijscrAuthors have retracted a case report describing a surgery to remove gallstones in a patient with Crohn’s disease after learning they’d mixed up two cases, and instead reported on a patient who had died 21 days after the procedure.

We were alerted to this story by La Repubblica, and contacted by the son of the patient (who asked not to be named, for privacy reasons). He told us he found the study and asked the journal to retract it:

…I can say that it was absolutely devastating to realise that the pictures I was looking at were from the surgery that led to the death of my father. It is something that gives me a lot of sorrow thinking that the man in that picture with the open belly was him, when he was fighting for his life. I asked the rest of my family not to see them to avoid them the same shock.

Even before the retraction appeared, we received confirmation it was coming from Giuseppe Paolisso, the Principal of the School of Medicine at the Second University of Naples, where the authors are based: Continue reading Son sees dead father in case report, requests retraction

Family squabble over safety of eye therapy forces journal to pull paper

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A father and son are fighting over whether a laser therapy they describe as co-authors of a 2015 paper could be harmful to patients, prompting the journal to retract the article.

The small study suggested that the therapy could safely treat patients with glaucoma. But Tomislav Ivandic — the father — alleges that errors in how the study was reported could lead to harmful doses of laser light for patients receiving the therapy. His son and co-author, Boris Ivandic, maintains that the article is accurate.

To err on the side of patient safety, Photomedicine and Laser Surgery retracted “Effects of Photobiomodulation Therapy on Patients with Primary Open Angle Glaucoma: A Pilot Study.”

The retraction note explains the dispute:

Continue reading Family squabble over safety of eye therapy forces journal to pull paper

Poll: Should there be a way to “self-retract” for honest error?

Daniele Fanelli
Daniele Fanelli

This week in Nature, Daniele Fanelli at Stanford made an interesting proposal: Set up a system of “self-retraction” that makes it crystal clear when a paper is pulled for honest error, rather than misconduct.

Fanelli, a whose work we have frequently covered, rightly notes that honest error represents a minority of retractions — around 20%. To remove any hint that a paper contains misconduct, Fanelli proposes designating self-retractions as those where all authors sign the retraction note:

Continue reading Poll: Should there be a way to “self-retract” for honest error?

FDA bans trial coordinator who pocketed patient funds and went to prison

The U.S. Food and Drug Administration (FDA) has permanently debarred a clinical trial coordinator from working on drug applications after he swapped patient stool samples for his own, and pocketed the money earmarked for patients — along with forging patient records, lab work, and doctors’ signatures.

The debarment is moot for time being — last year, Wesley McQuerry was sentenced to three years in prison for his misdeeds, according to the Chicago Sun-Times.

The FDA’s debarment, effective March 18, provides more details: Continue reading FDA bans trial coordinator who pocketed patient funds and went to prison