Heart journal issues expression of concern after fraud report

circulationThe American Heart Association’s journal Circulation has issued an expression of concern for a paper about the molecular underpinnings of arrhythmias that was co-authored by a biomedical engineer who committed fraud on a massive scale.

According to an investigation by the Office of Research Integrity (ORI), former Vanderbilt engineer Igor Dzhura faked nearly 70 images and drastically over-estimated the number of experiments he conducted. He was banned from receiving federal funding for three years.

The fraud has resulted in six retracted papers, Dzhura has agreed to retract six papers, which have been cited more than 500 times. [Ed. note: at this time, only one paper has actually been retracted]

Continue reading Heart journal issues expression of concern after fraud report

SfN journal retracts paper, bans UPenn researchers over “data misrepresentation”

journal of neuroscienceThe Journal of Neuroscience has yanked an Alzheimer’s paper and banned three University of Pennsylvania authors from publishing there temporarily, following conflicting investigations by the university and the publisher, the Society for Neuroscience, into the data.

The 2011 paper looked into the cellular makeup of the characteristic plaques that develop in the brains of people with Alzheimer’s disease. It’s been cited 64 times, according to Thomson Scientific’s Web of Knowledge.

While the notice states that Penn’s investigation “supports the journal’s findings of data misrepresentation,” last author Virginia Lee said she asked the journal to simply issue a correction of the faulty data, since the findings are “extremely important” for the field and have been affirmed by a later paper. According to author John Trojanowski (who is married to and publishes regularly with Lee), he and Lee have been barred from publishing in Journal for Neuroscience for several years. Senior Co-author Edward Lee is out for a year [see update at the bottom of this post].

Lee provided us with a letter Vice Dean of Research Glen Gaulton sent to the journal (click here to read), in which he says an investigation found “no evidence of research misconduct” and the “errors…do not detract from or otherwise alter the conclusions of the manuscript.”

Continue reading SfN journal retracts paper, bans UPenn researchers over “data misrepresentation”

Ob-gyn prof up to 7 retractions, latest due to “substantial data misrepresentation”

University of Florida
University of Florida

Two more retractions have popped up for Nasser Chegini, the former University of Florida professor currently under investigation by the Office of Research Integrity (ORI).

Both retractions appear in the Journal of Clinical Endocrinology & Metabolism. The notices indicate that an investigation report from the University of Florida “found substantial data misrepresentation” in two JCEM articles about Smads, signaling molecules that carry messages from TGF-beta receptors to the nucleus.

Here’s the notice for “The Expression of Smads in Human Endometrium and Regulation and Induction in Endometrial Epithelial and Stromal Cells by Transforming Growth Factor-Beta” (cited 28 times, according to Thomson Scientific’s Web of Knowledge):

Continue reading Ob-gyn prof up to 7 retractions, latest due to “substantial data misrepresentation”

Prominent geneticist David Latchman’s group notches second retraction

j cell scienceA team of researchers whose work is under investigation by University College London has retracted a second paper.

Three of the 11 authors of the 2005 Journal of Cell Science paper being retracted — David Latchman, Richard Knight, and Anastasis Stephanou — were authors of a Journal of Biological Chemistry paper retracted in January. Stephanou takes the blame for the “errors” which felled the Journal of Cell Science paper, about how a tumor suppressor responds to DNA damage.

Here’s the notice for “STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage:” Continue reading Prominent geneticist David Latchman’s group notches second retraction

Neuro journal pulls comatose brain abstract due to “several mistakes”

clinical neurophysiologySwiss researchers have retracted an abstract in Clinical Neurophysiology because only one of them actually knew about the paper — and what he submitted had “several mistakes.”

The abstract, about electric impulses in the brain of comatose patients, originally appeared as a poster at the June 2014 joint meeting of multiple Swiss neuroscience societies. It was submitted by first author Alexandre Simonin, who lists his affiliation as the University Hospital of Lausanne, a Swiss hospital.

The meeting proceedings ran in the October issue of Clinical Neurophysiology. Besides the issues of authorship and errors, the notice also says the abstract “potentially conflicts with another publication,” suggesting the data might have already appeared in a paper.

Here’s the notice for “P02. Predicting the outcome of post-anoxic comatose patients based on single-trial EEG analysis”: Continue reading Neuro journal pulls comatose brain abstract due to “several mistakes”

David Vaux: Nature’s decision to add double-blind peer review is good, but could be better

David Vaux, a cell biologist at the Walter + Eliza Hall Institute of Medical Research in Melbourne, explains how Nature could do more to remove bias from the peer review process. He previously wrote about his decision to retract a paper.

vaux
David Vaux

Last week, Nature announced that they are to offer authors of papers submitted to Nature or the monthly Nature research journals the option of having their manuscripts assessed by double-blind peer review, in which reviewers are blinded to the identity of authors and their institutions. Until now, papers sent to Nature, and most other journals, have been reviewed by a single-blind process, in which the reviewers know the identities and affiliations of the authors, but the authors are not told who the reviewers are. The goal of double-blind peer review is for submitted papers to be judged on their scientific merit alone, and thus to reduce publication bias.

While Nature should be applauded for this move, the way they have implemented it leaves room for improvement.

Continue reading David Vaux: Nature’s decision to add double-blind peer review is good, but could be better

Judge denies motion by researcher to quash Diabetes expressions of concern

Mario Saad, via unicamp.br
Mario Saad, via unicamp.br

American Diabetes Association 1, Mario Saad 0.

As reported by the National Law Journal, a federal judge in Boston has denied Saad’s requests to stop the ADA’s flagship journal, Diabetes, from publishing expressions of concern about four of Saad’s papers, and to prevent the journal from retracting the studies.

Saad filed suit against the ADA on February 5. Judge Timothy Hillman wrote in his order yesterday that approving the researcher’s motion would have violated the right to free speech: Continue reading Judge denies motion by researcher to quash Diabetes expressions of concern

Stats mistake crashes bike accident paper

Image via Thomas Hawk
Image via Thomas Hawk

Two researchers at the University of Saskatchewan in Canada have retracted a paper that came to fairly common-sense conclusions about bike safety.

In the September 2014 issue of the Journal of Transport and Health, the authors concluded that slippery road surfaces, night-time biking, and higher speed limits were all associated with higher probabilities of a bicycle accident.

Despite these logical conclusions, the authors discovered a statistical error that “would significantly change the discussion,” according to the retraction notice.

Continue reading Stats mistake crashes bike accident paper

More black marks against unapproved protein touted as miracle cure

clinical immunologyA protein which is sold online as a cure for everything from autism to cancer and the focus of multiple retracted papers has earned more black marks: The UK government’s Medicines and Healthcare Products Regulatory Agency has issued a warning about its use after discovering problems in the factory, and a journal has removed the last author from a paper touting its benefits in HIV.

The protein, vitamin D-binding protein-derived macrophage activating factor (GcMAF), is supposedly a natural activator of macrophages. The website GcMAF.eu continues to hawk the results of treatment, while the Anticancer Fund has been pushing journals to correct the record on GcMAF. Continue reading More black marks against unapproved protein touted as miracle cure

Science chemistry paper earns retraction after expression of concern, marking second for UT group

scienceThe authors of a 2011 Science paper that proposed a new way to direct chemical bonds have withdrawn the paper after concerns about the data prompted an investigation and Editorial Expression of Concern last year from the journal. The retraction is the second for the group, which has also had seven other expressions of concern.

After a reader emailed the editors to raise suspicions about the data, corresponding author Christopher W. Bielawski, then based at the University of Texas at Austin, led an investigation of all the figures. It found substantial problems: “In over 50% of the figure parts, the authors deemed the data unreliable due to uncertainty regarding the origin of data or the manner in which the data were processed,” according to the retraction notice.

UT Austin concluded that there had been misconduct, but did not elaborate.

Continue reading Science chemistry paper earns retraction after expression of concern, marking second for UT group