Fraud fells Alzheimer’s “made to order” neurons paper in Cell

cell414In 2011, a group of researchers at Columbia University reported in Cell that they had been able to convert skin cells from patients with Alzheimer’s disease into functioning neurons — a finding that raised the exciting prospect of “made to order” brain cells for patients with the degenerative disease. As one researcher not involved with the study, led by Asa Abeliovich, put it:

“[This is] simply a remarkable and complete piece of work which will now set a standard for stem cell work in neurological disease. The standard of the characterization of the neuronal cultures is very high,” John Hardy at University College London, U.K., wrote to [Alzforum]. He was not involved in the work but is taking a similar approach in his own lab.

According to the abstract of “Directed Conversion of Alzheimer’s Disease Patient Skin Fibroblasts into Functional Neurons:”

Continue reading Fraud fells Alzheimer’s “made to order” neurons paper in Cell

Harvard and the Brigham investigating leading heart group for “compromised” data

circulationcoverCirculation has retracted a 2012 study by a group of Harvard heart specialists over concerns of corrupt data, and the university is investigating. The group was led by Piero Anversa, a leading cardiologist, and Joseph Loscalzo — who will be familiar to readers of Circulation as the editor in chief of that journal. (Anversa’s also on the editorial board).

Continue reading Harvard and the Brigham investigating leading heart group for “compromised” data

Sex worker paper falls in data dispute

raps20.v010.i01.coverThe authors of a 2011 paper on sex workers in India have lost the article in a dispute over the provenance of the data.

The article, “Health of Home-Based Sex Workers and their Children in Rural Andhra Pradesh, India,” appeared in Asian Population Studies and was written by Monique M. Hennink and Solveig A. Cunningham, both of the Rollins School of Public Health at Emory University in Atlanta.

Here’s the abstract: Continue reading Sex worker paper falls in data dispute

RIP, Ed Rickards: Duke watchdog who covered Anil Potti case dies at 72

dukeIt’s unusual for us to post obituaries on Retraction Watch — we’ve published just one so far in three-and-a-half years — but we wanted to pause for a moment to note the passing of a tireless crusader for transparency and accountability whose electronic path crossed with ours a number of times since 2012 because of our shared interest in the case of Anil Potti.

We learned of the death of Ed Rickards this weekend while Ivan was attending ScienceOnline 2014. The Duke Chronicle, the university’s student newspaper, reported on February 5: Continue reading RIP, Ed Rickards: Duke watchdog who covered Anil Potti case dies at 72

Nature paper retracted following multiple failures to reproduce results

nature 2-27-14An international team of researchers from the NIH, Harvard, the University of Michigan, and two Chinese universities — Fourth Military Medical University and China Medical University — has retracted their 2012 paper in Nature after they — and a number of other groups — were unable to reproduce the key results.

The original abstract for “The NAD-dependent deacetylase SIRT2 is required for programmed necrosis” said that the findings

implicate SIRT2 as an important regulator of programmed necrosis and indicate that inhibitors of this deacetylase may constitute a novel approach to protect against necrotic injuries, including ischaemic stroke and myocardial infarction.

But here’s the notice, by corresponding author Toren Finkel and colleagues: Continue reading Nature paper retracted following multiple failures to reproduce results

Failure to reproduce leads to retraction of Nature Chemical Biology herbicide paper

nat chem bioA group of researchers at Emory has retracted a highly regarded paper after being unable to reproduce its key results.

Here’s the notice from Nature Chemical Biology: Continue reading Failure to reproduce leads to retraction of Nature Chemical Biology herbicide paper

Blood retracts two red cell illustrations that “could have misled” readers

blood cover214Blood has retracted two 2013 illustrations of red cells by researchers from South Africa and the United States because, somewhat confusingly, they didn’t conform to the journal’s criteria for publishing such material.

Here’s the notice for one of the images, “Red blood cell and platelet interactions in healthy females during early and late pregnancy, as well as postpartum”: Continue reading Blood retracts two red cell illustrations that “could have misled” readers

Emory cardiology researcher up to six retractions

R. Wayne Alexander, via Emory
R. Wayne Alexander, via Emory

R. Wayne Alexander, a cardiology researcher at Emory whose lab has retracted four papers following university investigations, has notched retractions five and six.

Here’s the notice from Circulation Research: Continue reading Emory cardiology researcher up to six retractions

Harvard student publication retracts article saying Jews deserve punishment because “they killed Jesus”

ichthusA Harvard student publication has retracted an article arguing that Jews deserved the persecution they’ve received for 2,000 years because they “killed Jesus.”

(We’ll do a few conflict of interest disclosures, if just for the hell — oops — of it: Harvard is Ivan’s alma mater, and both of us are well, Jews. We note, however, that the Ichthus was not around in Ivan’s Harvard days, and neither of us was around when the events involving Jesus described in this post occurred.)

As Talking Points Memo reported Thursday: Continue reading Harvard student publication retracts article saying Jews deserve punishment because “they killed Jesus”

Another image falsification retraction for Emory heart researchers

jbc1112coverA group of authors from Emory University, has lost another paper for image manipulation, bringing their total to at least four. What makes this particularly interesting is that the main actor in the figure fakery, Lian Zuo, does not appear to have been involved this time.

Zuo, you may recall, was cited in multiple retraction notices back in 2011 after Emory investigators concluded that he appeared to have been fabricating figures. But, one of the notices, from Circulation Research, raised the possibility that someone else was implicated, too: Continue reading Another image falsification retraction for Emory heart researchers