Category: mega-corrections

Structural biology corrections highlight best of the scientific process

Nature_latest-coverIf you need evidence of the value of transparency in science, check out a pair of recent corrections in the structural biology literature.

This past August, researchers led by Qiu-Xing Jiang at the University of Texas Southwestern Medical Center corrected their study, first published in February 2014 in eLife, of prion-like protein aggregates called MAVS filaments, to which they had ascribed the incorrect “helical symmetry.” In March, Richard Blumberg of Harvard Medical School, and colleagues corrected their 2014 Nature study of a protein complex called CEACAM1/TIM-3, whose structure they had attempted to solve using x-ray crystallography.

In both cases, external researchers were able to download and reanalyze the authors’ own data from public data repositories, making it quickly apparent what had gone wrong and how it needed to be fixed — highlighting the very best of a scientific process that is supposed to be self-correcting and collaborative. Continue reading Structural biology corrections highlight best of the scientific process

Stem cell researchers fix two papers following PubPeer comments

Screen Shot 2016-04-13 at 5.56.09 PMA pair of stem cell researchers have earned two corrections, the result of images that were mislabeled, distorted, or compiled incorrectly, according to the notices.

Kang Cheng prepared the gels when he was a research fellow in last author Sanjeev Gupta‘s lab at the Albert Einstein College of Medicine. Gupta told us he reviewed the original gels, and the errors didn’t affect the conclusions in the papers, which were reproducible. He noted he believes the problems are the result of honest mistakes:

The errors did not confer any benefits whatsoever either for the papers or for Dr. Cheng.

On PubPeer, commenters have raised questions about the now corrected papers — along with several others on which Gupta is the senior author, but Cheng is not a co-author.

Edward Burns, research integrity officer at Einstein, told us that the medical school looked into an allegation of misconduct against Gupta:  

Continue reading Stem cell researchers fix two papers following PubPeer comments

Five more notices for Duke pulmonary pair brings retraction tally into double digits

Two retractions and three corrections have appeared for a group of Duke researchers that already have 10+ retractions under their belts.

The reasoning behind them echoes that which we’ve seen before in notices for Michael Foster and Erin Potts-Kant: Following an inquiry from the university, the journals were informed that some of the data or results weren’t reliable, and not all of the experiments could be repeated.

A colleague aware of the case said that researchers are still working to repeat experiments from papers by Potts-Kant and Foster. It is not known how many more papers might be corrected or retracted. Duke University is fully supporting the validation of these experiments, the source told us.

Foster has retired from Duke, a spokesperson for the university confirmed. Continue reading Five more notices for Duke pulmonary pair brings retraction tally into double digits

Popular paper by famous longevity researcher gets mega-correction

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Leonard Guarente

A highly cited paper by a well-known scientist at the Massachusetts Institute of Technology who studies longevity could have aged better: The ten-year-old paper has earned its second correction.

It’s one of multiple papers by lead author Leonard Guarente that have been questioned on PubPeer. Guarente has already retracted one, and plans to address another. Continue reading Popular paper by famous longevity researcher gets mega-correction

So, pot may not be as harmless as a recent study suggested

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Researchers are correcting a widely covered study that suggested chronic use of pot might not put users at risk of problems later in life.

It turns out that initial, unexpected finding — covered by Newsweek, The Washington Post, Quartz, and (of course) The Stoner’s Cookbook (now known as HERB) — wasn’t quite right, and a reanalysis found users had a small uptick in risk for psychosis. The authors have issued a lengthy correction in Psychology of Addictive Behaviors that includes some supplemental analysis, too.

Not surprisingly, the study’s findings engendered some controversy, which prompted the authors to reanalyze their data, collected from 408 males with varying levels of marijuana use, who were followed from their teens into their 30s.

Now, an American Psychological Association press release that accompanied the initial findings in August contains an editors note explaining why those aren’t quite correct:

Continue reading So, pot may not be as harmless as a recent study suggested

List of retractions, corrections grows for Duke researchers

cov200hDuke researcher Michael Foster and his former co-author Erin Potts-Kant are adding to their notice count with a major correction from late last year to a paper on how certain cells in mice respond to a pneumonia infection, citing “potential discrepancies in the data.”

The correction is actually a partial retraction: The note explains that parts of three figures should be discounted.

We’ve also recently unearthed multiple corrections and two retractions from the pair that we missed from earlier in 2015.

After questions about the data in the corrected paper arose, the authors were able to replicate most of the experiments in the paper, according to the note. But since the paper was published, the senior author passed away, closing her lab, so they couldn’t repeat all of the work.

Here’s the correction notice for “Mast cell TNF receptors regulate responses to Mycoplasma pneumoniae in surfactant protein A (SP-A)−/− mice,” published in The Journal of Allergy and Clinical Immunology:

Continue reading List of retractions, corrections grows for Duke researchers

Voinnet’s notice count grows, as he notches his 18th correction

home_coverOlivier Voinnet, a high-profile plant scientist at ETH Zurich, has earned a mega-correction. It wrapped up a rough year for the biologist, which included his seventh retraction, and a CNRS investigation that found evidence of misconduct.

This latest correction, to a paper on the mechanisms behind RNA silencing in Arabidopsis, was published in RNA. The 2007 paper has been cited 101 times, according to Thomson Scientific’s Web of Knowledge. The corrigendum modifies three figures in total.

The notice is long, so we’re not going to post the whole thing here. The first error in “Transitivity in Arabidopsis can be primed, requires the redundant action of the antiviral Dicer-like 4 and Dicer-like 2, and is compromised by viral-encoded suppressor proteins” is a clarification to a legend:

Continue reading Voinnet’s notice count grows, as he notches his 18th correction

Correction changes results about genetics of neurological disorder

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A paper on the genetics underlying a common neurological disorder has issued a correction that influences the results of the paper.

“Genetic Diagnosis of Charcot-Marie-Tooth Disease in a Population by Next-Generation Sequencing” was published in BioMed Research International, and looked at 81 families with the disease. The researchers identified mutations that might be connected to the disease. The problem, says the correction note, is that the authors classified a couple variants in one patient’s genes as “likely pathogenic,” when their true nature was less clear.

The correction explains the new numbers:

Continue reading Correction changes results about genetics of neurological disorder

Management researcher with 7 retractions issues “clarifications” to 2013 paper

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The authors of a paper on supportive supervisors just want readers to “better understand the reported findings,” and so have issued multiple “clarifications” in a corrigendum note.

Some of the issues addressed in the note have been raised on PubPeer.

The paper’s author list includes one Fred Walumbwa, formerly an Arizona State University management researcher, some of whose work has succumbed to scrutiny in the the past two years. His current list: seven retractions, a megacorrection, an expression of concern, and now this.

“Unraveling the relationship between family-supportive supervisor and employee performance,” published in Group & Organization Management, has been cited twice, according to Thomson Scientific’s Web of Knowledge.

Here’s the note in full:

Continue reading Management researcher with 7 retractions issues “clarifications” to 2013 paper

Mega-correction for updated CPR reporting guidelines

CirculationA major correction has been posted for an update to international guidelines on reporting outcomes of people receiving cardiopulmonary resuscitation (CPR).

Circulation published the paper online in 2014; the correction was issued before it appeared in print, in the journal’s September 29, 2015 issue. “When reviewing the final proof for print publication, the author noticed some errors and requested changes,” according to a spokesperson for the journal’s publisher, the American Heart Association.

The notice is so long, we’re only including the first paragraph, most of which is taken up by just the title of the paper:

Continue reading Mega-correction for updated CPR reporting guidelines