Category: pulmonology

Duke University lung researchers cough up fourth retraction, due to “inconsistent” data

Journal of Applied PhysiologyThe Journal of Applied Physiology has retracted a 2012 respiratory study after the authors found “inconsistent” data that “could not be traced to their source.” It’s the fourth retraction for two of the researchers, including Erin Potts-Kant, who was arrested in 2013 for embezzling more than $14,000 from Duke University.

The study, “Effects of corticosteroid treatment on airway inflammation, mechanics, and hyperpolarized 3He magnetic resonance imaging in an allergic mouse model,” looked at how corticosteroid therapy, a steroid treatment used for asthma, worked on mice. It’s been cited four times, according to Thomson Scientific’s Web of Knowledge, and was one of the products of the environmental lung health research conducted by Potts-Kant and Duke professor William Foster, the other co-author on the retracted studies.

Here’s the complete retraction notice: Continue reading Duke University lung researchers cough up fourth retraction, due to “inconsistent” data

Retraction and republication for Lancet Resp Med tracheostomy paper

lancetrmA paper whose expression of concern we covered in November 2014 has been retracted and republished “because of the extent of the changes necessary,” according to the Lancet Respiratory Medicine.

This isn’t the first time we’ve seen retraction/republications at the Lancet, accompanied by thorough breakdowns of the problem.

This study was a meta-analysis of research on how the timing of tracheostomies — placing a breathing tube directly into the windpipe — affects patients’ mortality rate. The original paper found that critically ill patients who received a tracheostomy earlier fared better than those for whom the procedure was delayed for weeks after intubation, the recommended practice.

However, when the authors calculated how many patients died, they assumed that any patient who wasn’t discharged from the intensive care unit (ICU) had died there, instead of looking for other explanations. This made their estimates unreliable.

The publisher convened a panel, which ultimately decided retraction and republication was the most appropriate course of action.

The original expression of concern contained a quote from the authors about the “data discrepancy” that would later sink the paper: Continue reading Retraction and republication for Lancet Resp Med tracheostomy paper

COPD paper in JCI retracted following PubPeer critiques

jciA 2011 paper in the Journal of Clinical Investigation whose PubPeer entry we highlighted in September has been retracted.

Here’s the notice for “Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients,” a 2011 paper by researchers at Johns Hopkins and Imperial College: Continue reading COPD paper in JCI retracted following PubPeer critiques

Lancet journal puts ICU paper on watch after authors acknowledge potentially fatal flaw

lancetrmLancet Respiratory Medicine has issued an expression of concern for a meta-analysis on tracheostomy in the intensive care unit that they published earlier this year.

The paper, “Effect of early versus late or no tracheostomy on mortality of critically ill patients receiving mechanical ventilation: a systematic review and meta-analysis“, came from a group at Harvard, Weill Cornell and the University of Athens. The authors purported to find that: Continue reading Lancet journal puts ICU paper on watch after authors acknowledge potentially fatal flaw

Asthma study yanked for serious ethical violations

springerplusA paper in SpringerPlus on treating asthma with antioxidants was retracted on September 25 for something of a trifecta of ethical problems.

The retraction notice indicates that the patients never consented, there was no ethical review, and the university supposedly overseeing the study had no knowledge of it:

Continue reading Asthma study yanked for serious ethical violations

Why was that lung cancer paper retracted? The “authors’ reason,” of course

jthordisTwo researchers who wrote a review article on the genetics of lung cancer have retracted the paper. But why evidently is for them to know and us to find out.

The article, “Epigenetic aberrant methylation of tumor suppressor genes in small cell lung cancer,” was published in the August 2013 issue of the Journal of Thoracic Disease by authors from Shandong University in China.

According to the retraction notice: Continue reading Why was that lung cancer paper retracted? The “authors’ reason,” of course

“Protracted and unresolved authors dispute” and “striking similarities” lead to two retractions

panafmedjrIt’s been a busy month for retractions at the Pan African Medical Journal (PAMJ) — dedicated to “Better health through knowledge sharing and information dissemination.”

The journal has retracted a 2013 article by a group from Bangalore, India, for plagiarism. And unlike the authors, the editors didn’t mince words.

The paper, “Detection of ESBL among ampc producing enterobacteriaceae using inhibitor-based method,” concluded that: Continue reading “Protracted and unresolved authors dispute” and “striking similarities” lead to two retractions

Thorax retracts cystic fibrosis paper with bogus data

thoraxA group of European researchers is retracting their 2012 paper in Thorax on the link between cystic fibrosis and the common cold after discovering that the first author, a promising young microbiologist in Switzerland, had made up her data.

The article, titled “Impaired type I and type III interferon induction and rhinovirus control in human cystic fibrosis airway epithelial cells,” purported to describe:

a novel mechanism to explain the increased susceptibility of patients with CF to rhinovirus infections. A profound impairment of the antiviral early innate response in CF airway epithelial cells was identified, suggesting a potential use of IFNs in the treatment of rhinovirus-induced CF exacerbations.

The lead author was Marjolaine Vareille, who at the time was at the University of Bern. Vareille won a L’Oréal France grant in 2007 from the Fondation L’Oréal – Unesco-French Academy of Sciences. The paper has been cited eight times, according to Thomson Scientific’s Web of Knowledge.

But according to the retraction notice: Continue reading Thorax retracts cystic fibrosis paper with bogus data

Former Duke researcher charged with embezzlement has a paper retracted

j app physA new retraction notice in the Journal of Applied Physiology gives only a hint at the problems in the paper, but what it does say has led us to a story about one of its co-authors.

Here’s the notice, from a team at Duke: Continue reading Former Duke researcher charged with embezzlement has a paper retracted

University of Nebraska clears HIV researchers of misconduct

ajrccmLast August, we reported on an Expression of Concern in the American Journal of Respiratory and Critical Care Medicine for a paper on HIV and lung injury. The notice said that the University of Nebraska, home to several of the paper’s authors, had begun an inquiry.

Today, the university issued a statement on the case, clearing the researchers of misconduct: Continue reading University of Nebraska clears HIV researchers of misconduct