Category: clinical study retractions

Unspecified questions earn central line study an expression of concern

ajicThe American Journal of Infection Control has issued an expression of concern for a paper looking at ways to reduce infections associated with central venous catheters, or central lines.

The catheters are placed directly into a large vein and end close to the heart, allowing long-term access for medication or fluid administration. According to the CDC, infections associated with central lines cause thousands of deaths and cost billions of dollars every year.

Here’s the abstract for “Comparison of central line-associated bloodstream infection rates when changing to a zero fluid displacement intravenous needleless connector in acute care settings“: Continue reading Unspecified questions earn central line study an expression of concern

Lancet retracts and republishes cardiology paper with admirable notice

logo_lancetOne of the papers from a massive heart disease study in China, published in the Lancet, has been retracted and republished after the authors noticed a statistical error.

The article, by authors from Peking Union Medical College in China, Yale University, and elsewhere, presented the results of the China PEACE-Retrospective Acute Myocardial Infarction Study, part of a national initiative to study and improve care for cardiac problems. After being posted online on June 24, 2014, the authors noticed that they’d incorrectly weighed one of the cities in their calculations, which threw off a number of national estimates.

After the corrections were made, the paper was peer-reviewed again, and reviewers stated that despite the mistakes, the original conclusions were sound.

Today is a banner day on Retraction Watch: This is our second excellent example of transparency in 24 hours, and therefore the second entry in our “doing the right thing” category. An editorial lays out exactly what happened, including a timeline, allowing scientists to feel confident they’re basing the next research step on solid and accurate data. (We also appreciate the hat tip to the Committee on Publication Ethics retraction guidelines, which we often send out to editors of bad notices as a gentle reminder.)

Here’s the notice for “ST-segment elevation myocardial infarction in China from 2001 to 2011 (the China PEACE-Retrospective Acute Myocardial Infarction Study): a retrospective analysis of hospital data”: Continue reading Lancet retracts and republishes cardiology paper with admirable notice

Authors issue a model retraction for mistaken bacterial identity

jcmA group in the Netherlands has retracted a case study on the diarrheal pathogen Campylobacter jejuni, commonly found in animal feces, after repeated tests showed the bacteria was actually C. fetus, which also causes spontaneous abortion in cows and sheep.

The 46-year-old man who had previously had an aortic valve replacement came to the doctors with endocarditis, an inflammation of the heart. Initial tests showed that it was due to a C. jejuni infection, which often lives in chickens, wombats, kangaroos, and sheep.

Only a few cases of endocarditis caused by C. jejuni had ever been reported. Unfortunately, a thorough followup made it clear that a different pathogen was at play. Let’s consider this retraction a model for all others in its clarity and thoroughness.

Take it away, notice for “Aortic Homograft Endocarditis Caused by Campylobacter jejuni“: Continue reading Authors issue a model retraction for mistaken bacterial identity

Fraud retraction appears for deceased Maryland dental researcher

osomoporeA former dental researcher at the University of Maryland, Baltimore, has lost a 2009 paper in the journal Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology for fabricating his data on an NIH-funded study.

The researcher, Mark A. Scheper, is not identified in the retraction notice as the person implicated in the university investigation. However, one of his co-authors confirmed his involvement. Scheper died in January 2014 at age 45 of natural causes, according to the Maryland State Medical Examiner.

The article was titled “The oncogenic effects of constitutive Stat3 signaling in salivary gland cancer cells are mediated by survivin and modulated by the NSAID sulindac.” It appeared online in March 2009, and has been cited six times, according to Thomson Scientific’s Web of Knowledge.

According to the abstract: Continue reading Fraud retraction appears for deceased Maryland dental researcher

Bad image prompts correction of Harvard-Brigham stem cell paper by Anversa

circresA group of Harvard stem cell researchers who already have one retraction and an expression of concern now have a correction. This one’s in Circulation Research, and it involves an image that previously had been flagged as suspicious in our comments.

The group is led by Piero Anversa, who as we reported last year is one of two researchers suing Harvard because the institution’s investigation into their work

has cost them millions in a forfeited sale of their company, and job offers.

Continue reading Bad image prompts correction of Harvard-Brigham stem cell paper by Anversa

Former Pitt cancer researcher admits to faking findings

Dong Xiao
Dong Xiao

A former researcher at the University of Pittsburgh inflated the number of mice used in his experiments, and faked data in a number of images in a paper reporting the results, according to the Office of Research Integrity (ORI).

Dong Xiao admitting to having

intentionally fabricated data contained in a paper entitled ‘Guggulsterone inhibits prostate cancer growth via inactivation of Akt regulated by ATP citrate signaling,’ specifically Figure 6G,

the ORI reports. The paper was published in  in July 2014 in Oncotarget. Here’s Figure 6: Continue reading Former Pitt cancer researcher admits to faking findings

Retracted paper on herbicide-ovarian cancer connection republished

ehpA retracted 2008 paper originally flagged by Clare Francis has been republished in Environmental Health Perspectives with updated figures and new data.

According to the editor’s note appended to the newly published paper, there was no evidence of intentional misconduct on the part of the authors. The new paper went through peer review as an entirely new submission, and comes to the same conclusion as the original:  Continue reading Retracted paper on herbicide-ovarian cancer connection republished

Franken-paper from U.S. federal contractor heads to the grave

Image via Insomnia Cured Here.
Image via Insomnia Cured Here.

Hindawi journal PPAR Research has pulled a cancer immunology paper after discovering it contained almost no new information.

Instead, it was a Frankenstein-style stitch job, containing sentences ripped from 33 different papers. 18 of those ended up in the citations; for 15 more, the authors didn’t even do them that courtesy. You can see a meticulously color-coded call out here.

Here’s the notice for “A Role for PPARy in the Regulation of Cytokines in Immune Cells and Cancer”: Continue reading Franken-paper from U.S. federal contractor heads to the grave

Duplicate submission forces retraction of derm laser paper

jclasertherThe Journal of Cosmetic and Laser Therapy has retracted a 2014 paper by a group of South Korean researchers after determining that the authors had doubled up on their publishing odds by submitting the manuscript to a competing journal.

The article was titled “A comparative study of low-fluence 1064-nm Q-switched Nd:YAG laser with or without chemical peeling using Jessner’s solution in melasma patients,” and it purported to find that:

This study suggests Jessner’s peel is a safe and effective method in the early course of treatment for melasma when combined with low-fluence 1064-nm Q-switched Nd:YAG laser.

Continue reading Duplicate submission forces retraction of derm laser paper

Leading diabetes researcher corrects paper as more than a dozen studies are questioned on PubPeer

maelder
Kathrin Maedler

Prominent German diabetes researcher Kathrin Maedler has issued corrections on two papers, and told Retraction Watch she is in the process of defending the data on others.

14 of her papers have been critiqued by PubPeer commenters. The commentary, which spans from her graduate work in 2002 to a 2014 publication in Nature Medicine, includes questions about image manipulation and self-plagiarism.

Laborjournal’s blog (we have a column in their English-language publication) first flagged these suspicions in July 2014, after being approached by pseudonymous Clare Francis.

Here’s a comparison between figures in Maedler’s 2009 PLoS One paper, “Deletion of the Mitochondrial Flavoprotein Apoptosis Inducing Factor (AIF) Induces β-Cell Apoptosis and Impairs β-Cell Mass,” and one she co-authored in 2006 in Diabetes, “Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets,” via PubPeer:  Continue reading Leading diabetes researcher corrects paper as more than a dozen studies are questioned on PubPeer