Category: clinical study retractions

“A decision of misconduct was reached”: Two lung papers expire

JofAnesthTwo papers about the molecular underpinnings of lung damage are being retracted following an investigation at Oita University in Japan, which revealed that images from both papers had been used to depict “different experimental conditions” in a third paper (which has not been retracted).

It’s not clear which of the authors were the subject of the investigation. The two retracted papers, “Nafamostat mesilate inhibits the expression of HMGB1 in lipopolysaccharide-induced acute lung injury” in the Journal of Anesthesia and “Coexpression of HSP47 Gene and Type I and Type III Collagen Genes in LPS-Induced Pulmonary Fibrosis in Rats” in Lung, both originally published in 2007, share the same first author — Satoshi Hagiwara, whose affiliation is listed as the Department of Brain and Nerve Science, Anesthesiology, Oita University Faculty of Medicine. The papers have been cited 13 times and 12 times, respectively, according to Thomson Scientific’s Web of Knowledge. Hagiwara is also the first author on the third paper that contains the duplicated images.

The first retraction notice reads:

Continue reading “A decision of misconduct was reached”: Two lung papers expire

We’ll tell you later, says ophthalmology journal about retracted paper

EurOpthRevThe European Ophthalmic Review has retracted a 2014 article about the macular degeneration drug aflibercept without any explanation.

Here’s the retraction notice, such as it is:

Continue reading We’ll tell you later, says ophthalmology journal about retracted paper

Yet another investigation casts doubt on Förster’s findings; he responds with “outrage”

Jens Förster
Jens Förster

A new group of experts is suggesting there’s something fishy in the body of work of social psychologist Jens Förster.

The University of Amsterdam, Förster’s former employer, commissioned three statistical experts to examine his publication record, looking for signs that the data are not authentic.

Well, they found some signs:

Continue reading Yet another investigation casts doubt on Förster’s findings; he responds with “outrage”

Heart repair study retraction marks second for Mercer University researcher

BasicResCardio_ak12Authors of a study on cardiac repair after heart attack are retracting it from Basic Research in Cardiology because they used “the same samples… to represent two distinct groups on two occasions.”

We find the language of the retraction somewhat confusing, but to the best of our understanding it means that they compared apples to the exact same apples.

The study, published online in 2012, examined the mechanism behind the beneficial effects of a procedure called postconditioning in treating heart attacks. Here’s the retraction notice: Continue reading Heart repair study retraction marks second for Mercer University researcher

“The first author assumes all responsibility:” Malaria vaccine article retracted for image manipulation

InfectAndImmunAuthors of a 2012 article in Infection and Immunity investigating a malaria vaccine strategy are retracting it because it “contains several images that do not accurately reflect the experimental data.”

The paper, “Fine Specificity of Plasmodium vivax Duffy Binding Protein Binding Engagement of the Duffy Antigen on Human Erythrocytes,” has been cited 9 times, according to Thomson Scientific’s Web of Knowledge.

The retraction notice places the blame for the image shenanigans squarely on the first author, Asim Siddiqui, who is currently listed on LinkedIn as a faculty member at the College of Applied Medicine at King Saud University in Saudi Arabia.

Here’s the notice: Continue reading “The first author assumes all responsibility:” Malaria vaccine article retracted for image manipulation

Highly cited paper on women and heart disease retracted for failure to replicate

jcemA highly cited study examining the risks of heart disease in post-menopausal women with symptoms of polycystic ovary syndrome (PCOS) has been retracted by its authors because they could not replicate the results.

Here’s the retraction notice for the paper, which appeared in the Journal of Clinical Endocrinology & Metabolism: Continue reading Highly cited paper on women and heart disease retracted for failure to replicate

Duplication snuffs out pollen abstract

AACIA Canadian research team has retracted a meeting abstract “published in error” from a supplement by Allergy, Asthma & Clinical Immunology, as it had previously been published in another journal.

The December 2014 abstract, “A post-hoc qualitative analysis of real time heads-up pollen counting versus traditional microscopy counting in the environmental exposure unit (EEU),” describes a custom digital imaging method for counting pollen in real-time. The abstract was published ten months earlier, in February 2014, under the same title in the Journal of Allergy and Clinical Immunology.

Here is the full retraction note:

Continue reading Duplication snuffs out pollen abstract

Clinical trial of Achilles tendon therapy retracted for not actually being a clinical trial

JBJS_ak6The Journal of Bone and Joint Surgery has retracted a 2012 paper because of ethical violations, initially flagged by the journal in 2013.

The study, which examined the use of autologous cell therapy in treating Achilles tendinosis, claimed in its abstract to have “conducted a randomized, double-blind study on forty Achilles tendons in thirty-two patients.” Apparently, though, it wasn’t actually a clinical trial but was somehow, according to the retraction notice, “misclassified” as such “in error.”

The problem was originally flagged by the UK’s Medicines and Healthcare products Regulatory Agency, which wrote the journal to tell them that it hadn’t granted ethical approval for the study, as we reported in 2013. At the time, there was a question about whether the lead author had retained records of the results, which is addressed in the retraction notice, signed by editor-in-chief Marc F. Swiontkowski and editor-in-Chief Emeritus Vernon T. Tolo: Continue reading Clinical trial of Achilles tendon therapy retracted for not actually being a clinical trial

Third retraction for GWU biologist as university seeks to dismiss his $8 million lawsuit

Rakesh Kumar, via George Washington University
Rakesh Kumar, via George Washington University

Cancer biologist Rakesh Kumar has chalked up another retraction, this time for “identical,” “duplicated,” and “replicated” figures and images.

It comes on the heels of a flurry of motions in Kumar’s $8 million lawsuit against his employer, George Washington University, for breach of contract and emotional distress because it removed him as department chair last year and placed his research on hold. Kumar remains employed by the university.

The retracted paper, published in Development in 2004, “Metastasis-associated protein 1 deregulation causes inappropriate mammary gland development and tumorigenesis,” analyzed the role of a protein, MTA1, in mammary gland development and cancer. It was published while Kumar was at M.D. Anderson in Houston, and has been cited 81 times, according to Thomson Scientific’s Web of Knowledge.

By our count, Kumar now has three retractions and five corrections. Numerous anonymous comments on Kumar’s papers have been posted on PubPeer, many of them critiquing images. Here’s the complete notice from Development: Continue reading Third retraction for GWU biologist as university seeks to dismiss his $8 million lawsuit

PNAS paper on dengue virus pulled due to contamination

PNAS_ak11smThe authors of a paper on dengue virus vaccine design published last year in PNAS are retracting it after discovering that their experimental dengue virus was contaminated.

Although they are confident that the strategy is sound, the authors write in their commendably detailed retraction notice that the “inadvertent error” rendered the results “uninterpretable.”

Here’s the retraction notice: Continue reading PNAS paper on dengue virus pulled due to contamination