Category: clinical study retractions

Drugmaker accused of omitting side effect data from 2003 Risperdal paper

cover7607A 2003 paper may have left out potentially “significant” data on the long-term side-effects of an antipsychotic drug used in children, according to a former head of the U.S. Food and Drug Administration.

As reported by the Toronto Star, David Kessler is alleging that Janssen, the maker of Risperdal (and owned by Johnson & Johnson), omitted data about the risks of the drug: In particular, that boys who use it over a long period may be at risk of growing breasts.

There’s anecdotal evidence of the side effect. One family claimed the drug had caused their son to grow a pair of 46 DD-sized breasts in a lawsuit against Johnson & Johnson, reported the Wall Street Journal in February. They won, to the tune of $2.5 million. The suit is apparently just one of 1,200 like it.

The abstract of the paper, “Prolactin levels during long-term risperidone treatment in children and adolescents,” published in The Journal of Clinical Psychiatry, suggests that levels of a key hormone aren’t a problem in the long term:

Continue reading Drugmaker accused of omitting side effect data from 2003 Risperdal paper

Authors withdraw immunology study, no reasons given

Journal of Biological Chemistry1Researchers have withdrawn a 2010 article in the Journal of Biological Chemistry about an immune regulator.

The paper was pulled without any explanation (in standard JBC style). Here’s the complete notice:

This article has been withdrawn by the authors.

The study’s authors were based out of Shandong University Medical School, Jinan General Hospital of Jinan Command and Duke University Medical Center.

Two of the authors have had previous papers retracted.

Continue reading Authors withdraw immunology study, no reasons given

The worm has turned: Nematode study retracted for misidentification

toxicol patholThe authors of a paper on parasitic nematodes have retracted the article because they misidentified the organism in question, so “the possibility of misleading readers was high.”

The paper, “Histopathological features of Capillaria hepatica infection in laboratory rabbits,” appeared in Toxicologic Pathology in 2009 and came from a lab at Huntingdon Life Sciences, in Cambridgeshire, England.

According to the abstract: Continue reading The worm has turned: Nematode study retracted for misidentification

Canadian researchers in legal battle over investigation object to third retraction

The Journal of Clinical InvestigationA third retraction — and a notice of concern — have emerged from the investigation into a husband and wife research team at the University of Toronto that found evidence of faked images and duplicated data.

The problem, according to the latest retraction note for Sylvia Asa and Shereen Ezzat, in the Journal of Clinical Investigation: Portions of the RT-PCR gels “are duplicated in this publication and in a subsequent publication.” That subsequent publication is a 2003 paper that has received a Notice of Concern from the American Journal of Pathology.

According to the retraction note, co-author Gillian E. Wu of York University signed off on the journal’s decision, but Asa, Ezzat and second author Lei Zheng dissented to the retraction. Third author Xian-Feng Zhu couldn’t be reached. Although corresponding author Asa noted that “the initial screen of these samples support the conclusions made in the paper,” the JCI made its position perfectly clear in the note:

Continue reading Canadian researchers in legal battle over investigation object to third retraction

Plague or anthrax on the subway? Think again, says now-corrected study

Cell SystemsAuthors of a widely covered study that documented traces of plague and anthrax on surfaces across New York City have revised the paper after public health officials challenged their interpretations of the data.

It’s hard to overestimate the attention these findings received when first published.

“Bubonic plague found in NYC subway,” wrote The Daily Beast.

“Your subway seat mate: Bubonic plague, anthrax, & mysterious DNA,” said Yahoo!

“NY subway has bubonic plague,” declared Newser.

Not so fast. In an erratum published July 29, the authors write: Continue reading Plague or anthrax on the subway? Think again, says now-corrected study

Nutrition researcher Chandra loses libel case against CBC

CBCThe self-proclaimed “father of nutritional immunology,” Ranjit Kumar Chandra, has lost a libel lawsuit against the Canadian Broadcasting Company (CBC).

The suit was in response to a 2006 three-part documentary from the CBC, which examined allegations of fraud against the former Memorial University researcher.

After the 58-day trial, the Ontario Superior Court of Justice “ruled in favour of CBC, on the grounds that the words in the broadcast were true,” according to CBC producer Lynn Burgess: Continue reading Nutrition researcher Chandra loses libel case against CBC

Golden rice paper pulled after judge rules for journal

home_coverThe American Journal of Clinical Nutrition is retracting a paper that showed genetically engineered rice serves as an effective vitamin A supplement after a Massachusetts judge denied the first author’s motion for an injunction against the publisher.

The journal announced plans to retract the paper last year following allegations that the paper contained ethical mis-steps, such as not getting informed consent from the parents of children eating the rice, and faking ethics approval documents.

Last July, first author Guangwen Tang at Tufts University filed a complaint and motion for preliminary injunction against the journal’s publisher, the American Society for Nutrition, to stop the retraction.

According to the ASN, on July 17, a Massachusetts Superior Court “cleared the way” for the publisher to retract the paper. So they have, as of July 29. Here’s more from the retraction notice:

Continue reading Golden rice paper pulled after judge rules for journal

“Falsified” data shelve two more drug studies from discredited U Colorado student

The authors of a pair of papers in Molecular Pharmaceutics are retracting them following an investigation at the University of Colorado Denver, which found a graduate student had faked data.

Rajendra Kadam was a prominent member of the Research lab of Uday B. Kompella, until the investigation revealed earlier this year that he had “falsified” data from a liquid chromatography-mass spectroscopy (LC-MS) machine for years.

So far, we’ve found four retractions (including the latest two) and one expression of concern for Kadam. There may be more on the way: Continue reading “Falsified” data shelve two more drug studies from discredited U Colorado student

Oregon grad student admits to faking data in four neuroscience papers

oriweb_logoA graduate student at the University of Oregon in Eugene has admitted to faking data that appeared in four published papers in the field of visual working memory, according to the Office of Research Integrity.

David Anderson’s supervisor at the time was Edward Awh, who has since moved to the University of Chicago.

Anderson told Retraction Watch that the misconduct stemmed from “an error in judgment”:

Continue reading Oregon grad student admits to faking data in four neuroscience papers

Author’s ties to NFL lead to correction for review that cast doubt on brain risk from sports

PLOS ONE

A review paper that suggested the degenerative brain disease that’s striking former football players may not be tied to contact sports has been corrected to reveal the first author spent decades working for the National Football League.

The correction appears in a review in PLOS ONE about chronic traumatic encephalopathy – the degenerative brain disease that was the basis of a $765 million settlement for former NFL players, along with a number of similar lawsuits. It fixes incorrect statements and adds conflicts of interest, including those with with first author Joseph Maroon, who spent more than 30 years working with the NFL and seven for the wrestling group the WWE.

It appears as if all the original paper declared was that Maroon was an “unpaid consultant” to the Pittsburgh Steelers. But apparently there was a lot more to it, according to the notice:

Continue reading Author’s ties to NFL lead to correction for review that cast doubt on brain risk from sports