Category: clinical study retractions

Journal retracts — and republishes — small study on gamma rays for OCD

Screen Shot 2015-10-28 at 8.40.00 PMJAMA Psychiatry has retracted and republished a paper on a cutting-edge procedure for patients with obsessive compulsive disorder.

In the original paper, the authors claimed that three out of eight patients who underwent a procedure that used gamma rays to kill brain cells showed improvements 12 months later (versus zero in the group who underwent a “sham” procedure). But after a reader noticed an “inadvertent” error in the calculation of how many patients had improved, the authors realized that only two of the patients had responded meaningfully to the procedure.

The new results “did not reach statistical significance,” the authors write in a “Notice of Retraction and Replacement.”  JAMA Psychiatry published it yesterday, along with a new version of the article, a letter from psychiatrist Christopher Baethge pointing out the error, and an editorial. The original article is available in the supplemental material of the new version, with the errors highlighted.

Here’s the note in full for “Gamma ventral capsulotomy for obsessive-compulsive disorder: a randomized clinical trial,” which explains the error:

Continue reading Journal retracts — and republishes — small study on gamma rays for OCD

After court verdict, BMJ retracts 26-year-old paper

downloadToday, The BMJ retracted a 1989 paper about the role of breastfeeding and formula in infant eczema — 20 years after the data were called into question by a university report.

However, the report was kept secret — due, by some accounts, to alleged threats of a lawsuit. That is, until this year, when author Ranjit Kumar Chandra — who once dubbed himself the “father of nutritional immunology” — lost a $132 million libel case. That case, against the Canadian Broadcasting Company (CBC) for airing a three-part documentary series on allegations of fraud against Chandra, pushed the report by his former employer Memorial University of Newfoundland into the public domain.

At 26 years, the BMJ retraction is a runner up for the longest amount of time a journal has taken to retract a paper. (We know of another retraction that was 27 years in the making, and a scientist who requested the retraction of some passages of a 1955 article in 2007, after the article became fodder for creationists.)

Here’s the first part of the retraction note:

Continue reading After court verdict, BMJ retracts 26-year-old paper

Bone researcher manipulated data in JAMA study, says investigation

Screen Shot 2015-10-27 at 10.53.53 AMA bone researcher manipulated data in a 2011 JAMA study about an inexpensive treatment for osteoporosis. That’s the conclusion of an investigation at the researcher’s former workplace, the Women’s College Hospital in Toronto, the Toronto Star reports.

The study — led and manipulated by Sophie Jamal — followed 243 women over two years, as they applied nitroglycerin ointment once a day. The ointment is currently used to prevent chest pain and treat anal fissure pain by relaxing blood vessels; Jamal’s study concluded it could help patients with osteoporosis, too:

Among postmenopausal women, nitroglycerin ointment modestly increased [bone mineral density] and decreased bone resorption.

But even the modest effect was too good to be true. Continue reading Bone researcher manipulated data in JAMA study, says investigation

Correction restores confidence in results of confidence study

Strategic Management JournalA study that looked at how entrepreneurs’ confidence levels change depending on market conditions has been corrected to fix an error that flipped the results of one of the experiments.

The paper was published in 2013 by the Strategic Management Journal, and explored how entrepreneurs stay confident in difficult marketplaces by studying how people reacted to tasks of varying difficulty. In one experiment, participants were asked how well they thought they did on an easy quiz and how well they did on a hard quiz. Results showed that “participants underestimated their scores on the easy quiz” and “overestimated their performance on the difficult quiz.” However, authors wrote the opposite in the final paper.

Here’s the correction notice for “Making Sense of Overconfidence in Market Entry”:

Continue reading Correction restores confidence in results of confidence study

Cochrane withdraws criticized alcohol misuse report for “major errors”

Cochrane_LogoThe Cochrane Library has withdrawn a criticized 2014 meta-analysis about a technique to help young people avoid alcohol abuse, because of “major errors.” 

The review found that motivational interviewing, a form of counseling to help people change behaviors, showed some effects but had “no substantive, meaningful benefits” in preventing alcohol abuse among people 25 and younger. However, other researchers in the field, including some whose studies were included in the analysis, soon raised concerns about the review’s methods and data calculation, and the authors withdrew it. 

Here’s the brief notice for “Motivational interviewing for alcohol misuse in young adults:”

Continue reading Cochrane withdraws criticized alcohol misuse report for “major errors”

Surgery journal publishes — then retracts — response to letter that never appeared

Annals of Surgery

How’s this for confusing: A surgery journal is retracting researchers’ response to a letter about their paper, because the letter was never actually published.

According to the managing editor of the Annals of Surgery, the letter — about a 2011 analysis of IV fluids in trauma patients — was accepted, prompting the journal to ask for a response from the authors of the 2011 paper. But the letter-writers never supplied required forms, such as conflict of interest. After spending two years trying to track them down, the journal decided not to publish the letter.

In the meantime, however, the authors’ response to the letter was “inadvertently published,” forcing the journal to retract it. Continue reading Surgery journal publishes — then retracts — response to letter that never appeared

BMC investigating allegedly copied paper

logoBioMed Central is investigating a recent paper about a potential biomarker for liver cancer, which shows signs it was written using another article as a template.

According to Jeffrey Beall, who exposed the similarities between the two papers on his blog Scholarly Open Access yesterday, the paper in question is “obviously bogus,” and appears to have relied on the “template plagiarism” technique of creating a new article by modifying a previous paper’s text and data.

A spokesperson for BioMed Central, which published the allegedly “junk” paper, as Beall calls it, told us they are looking into the allegations: Continue reading BMC investigating allegedly copied paper

Authors retract second study about medical uses of honey

Journal of Clinical NursingA paper that tested the clinical value of honey on venous ulcers has been pulled by the Journal of Clinical Nursing after an investigation uncovered “errors in the data analysis.” Last year, the authors pulled another paper on the healing properties of honey on wounds. 

We just discovered this second retraction, which appears in the September 2015 issue of the journal, but was posted online last year.

The journal’s editor-in-chief, Debra Jackson, confirmed the dates and said that “a commercial company” brought the matter to their attention. After the journal asked a statistician to weigh in, they stated that a “substantial re-write would be required to correct the article,” and a retraction would be “the most suitable course of action.”

Although she said the authors initially sought to correct, not retract, the study, they eventually agreed with the decision.

Here’s the notice:

Continue reading Authors retract second study about medical uses of honey

Diederik Stapel retraction count updated to 57

stapel_npcWe’ve learned about two more retractions we missed for Diederick Stapel, the Dutch social psychology researcher who has now racked up a total of 57 retractions by our count.

Both retractions were issued after a committee released a report which established fraud in dozens of papers co-authored by Stapel.

Stapel is still #4 on our leaderboard.

Continue reading Diederik Stapel retraction count updated to 57

“Insufficient permission” from funder resects liver disease paper

HepatologyA study on chronic liver inflammation was pulled from the journal Hepatology because of “insufficient permission by the authors’ funding institution to submit and publish the manuscript.” 

The paper, which was published in July, looked into how steatosis, the abnormal retention of fat in the liver, turns into steatohepatitis, also known as fatty liver disease. Researchers found that Treg cells play a central role in controlling the disease.

Unfortunately, the journal’s managing editor didn’t provide any information about the nature of the permission problems, and the notice doesn’t give any details.

Here it is, in full:

Continue reading “Insufficient permission” from funder resects liver disease paper