Category: clinical study retractions

Retractions aren’t enough: Why science has bigger problems

Andrew Gelman
Andrew Gelman

Scientific fraud isn’t what keeps Andrew Gelman, a professor of statistics at Columbia University in New York, up at night. Rather, it’s the sheer number of unreliable studies — uncorrected, unretracted — that have littered the literature. He tells us more, below.

Whatever the vast majority of retractions are, they’re a tiny fraction of the number of papers that are just wrong — by which I mean they present no good empirical evidence for their claims.

I’ve personally had to correct two of my published articles.   Continue reading Retractions aren’t enough: Why science has bigger problems

Journal pulls parasite paper over potential for patient harm

Parasitology ResearchA journal has retracted a paper about a molecular diagnosis for leishmaniasis out of concern it could lead to incorrect clinical diagnoses. 

According to Parasitology Research, all data behind the figures in the main manuscript and supporting information are correct, but the authors’ misinterpretation of the data could lead doctors to diagnose patients incorrectly. 

Let’s take a look at the retraction notice, which tells us a bit more about the nature of the problem: Continue reading Journal pulls parasite paper over potential for patient harm

Nature fixes highly cited paper suggesting food additives hurt the gut

Nature_latest coverA 2015 study about dietary emulsifiers has been corrected by Nature after another researcher pointed out a few ambiguities.

When it first appeared, the study — which showed emulsifiers cause inflammation in the guts of mice — received a fair amount of media attention, including from Nature’s own news department. But since publication, a researcher noted some imprecision around the ages of mice used in the sample, affecting the paper’s calculations of weight gain over time. Andrew Gewirtz, co-author of the study from Georgia State University, told us the change did not affect the conclusions of the paper.

Here’s the corrigendum for “Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome”: Continue reading Nature fixes highly cited paper suggesting food additives hurt the gut

In precedent break, BMJ explains why it rejected controversial “weekend effect” paper

After the reviewer of a rejected paper was publicly outed, the BMJ has taken the unusual step of explaining why it chose not to publish the paper.

The paper — eventually published in another journal — raised hackles for suggesting that there is no “weekend effect,” or a higher mortality rate in hospitals on Saturday and Sunday. This caught the attention of UK policy makers, who have proposed changing policies to compensate for any supposed “weekend effect.”

Amidst the heated discussion about the research, one of the reviewers was identified, along with suggestions that he may have been conflicted because he had published a study showing the opposite finding. Yesterday, the BMJ posted a blog explaining that it was the editors — and not one sole reviewer — who decided to reject the paper: Continue reading In precedent break, BMJ explains why it rejected controversial “weekend effect” paper

Publicly available data on thousands of OKCupid users pulled over copyright claim

okcupidThe Open Science Framework (OSF) has pulled a dataset from 70,000 users of the online dating site OkCupid over copyright concerns, according to the study author.

The release of the dataset generated concerns, by making personal information — including personality traits — publicly available.

Emil Kirkegaard, a master’s student at Aarhus University in Denmark, told us that the OSF removed the data from its site after OkCupid filed a claim under the Digital Millennium Copyright Act (DMCA), which requires the host of online content to remove it under certain conditions. Kirkegaard also submitted a paper based on this dataset to the journal he edits, Open Differential Psychology. But with the dataset no longer public, the fate of the paper is subject to “internal discussions,” he told us.

In place of the dataset on OSF, this message now appears: Continue reading Publicly available data on thousands of OKCupid users pulled over copyright claim

Dairy journal retracts paper lacking co-authors’ consent

Dairy science and technologyA journal about dairy science has retracted a paper after learning that it was published without the consent of all its authors.

An independent inquiry found no evidence of research misconduct, but nevertheless recommended that the institution — Curtin University in Perth, Australia — request to retract the paper.

Here’s the retraction notice, published in Dairy Science and Technology: Continue reading Dairy journal retracts paper lacking co-authors’ consent

Researchers decry study warning of low-carb diet risks

Nutrition and DiabetesAdvocates of low-carbohydrate diet are voicing concern about a recent paper that suggested the diet could cause weight gain, contrary to previous research. One expert has even called for its retraction.

The study, published in Nutrition & Diabetes in February, also found that the low-carb diet did little to prevent the progression of type 2 diabetes. Researchers have since criticized the study for drawing these conclusions based on data from a handful of mice, using a poor proxy for the human version of the diet.

One expert took to social media to warn against the study’s message regarding the low-carb, high-fat diet (LCHF); for instance, obesity & nutrition researcher and author, Zoë Harcombe from Newport, Wales, tweeted: Continue reading Researchers decry study warning of low-carb diet risks

In major shift, medical journal to publish protocols along with clinical trials

AIMA major medical journal has updated its instructions to authors, now requiring that they publish protocols of clinical trials, along with any changes made along the way.

We learned of this change via the COMPare project, which has been tracking trial protocol changes in major medical journals — and been critical of the Annals of Internal Medicine‘s response to those changes. However, Darren Taichman, the executive deputy editor of the journal, told us the journal’s decision to publish trial protocols was a long time coming: Continue reading In major shift, medical journal to publish protocols along with clinical trials

After painful retraction, authors republish replicated findings five years later

chembiochemIt was one of the most difficult posts we’ve ever written: A researcher’s eagerness to publish a paper before asking all co-authors for their permission forced him to retract the article, wasting a postdoc’s time and destroying a professional relationship in the process.

This 2011 post wasn’t difficult to write because the facts were complex; they weren’t particularly (although the science involved was intricate). Rather, the man responsible for the incident, Graham Ellis-Davies, was so clearly and sincerely distressed by the mistake he’d made, it was impossible not to feel sorry for the him.

Well, we’re delighted to report that the tale has a happy ending. Ellis-Davies and his former postdoc have recently republished their once-retracted work with a new set of co-authors — and in the same journal that previous retracted it. What’s more, they have turned what initially was a proof-of-concept study into a much more robust article with exciting implications for the field.  Continue reading After painful retraction, authors republish replicated findings five years later

“I shared:” Can tagging papers that share data boost the practice?

Psychological Science

After a journal began tagging papers that adopted open science practices — such as sharing data and materials — a few other scientists may have been nudged into doing the same.

In January 2014, Psychological Science began rewarding digital badges to authors who committed to open science practices such as sharing the data and materials. A study published today in PLOS Biology looks at whether publicizing such behavior helps encourage others to follow their leads. 

The authors summarize their main findings in the paper:
Continue reading “I shared:” Can tagging papers that share data boost the practice?