Category: clinical study retractions

NUS: Melendez committed “serious scientific misconduct,” but don’t expect to get any details

alirio_melendezAlirio Melendez, a former National University of Singapore immunologist whose story we’ve been following here since a retraction in September of last year, committed misconduct on an “unprecedented” scale, according to the university, involving more than 20 papers.

Nature’s Richard van Noorden has the scoop:

After a 19-month investigation, the National University of Singapore (NUS) today says that it has determined that one of its former scientists, the immunologist Alirio Melendez, has committed “serious scientific misconduct”.  The university found fabrication, falsification or plagiarism associated with 21 papers, and no evidence indicating that other co-authors were involved in the misconduct, it says.

Melendez has retracted five papers so far, as we’ve reported, but NUS wouldn’t give the whole list. They tell Nature: Continue reading NUS: Melendez committed “serious scientific misconduct,” but don’t expect to get any details

Concern — in triplicate — arrives for Poldermans papers

Jacc1212coverThe Journal of the American College of Cardiology, or JACC, has issued expressions of concern for three papers by Don Poldermans, the Dutch cardiologist who was fired earlier this year amid allegations of misconduct.

Cardiobrief’s Larry Husten had the story first.

The, um, heart of the matter is that neither the investigators at Erasmus Medical Center, Poldermans’ former institution, nor the JACC editors, can say whether the researchers conduct rose to the level of fabricating data. As the Notice of Concern states: Continue reading Concern — in triplicate — arrives for Poldermans papers

Dental papers retracted after investigations find “issue with respect to misconduct”

jomfpSometimes, retraction notices offer tantalizing clues, but no real information. Take the case of a paper called “Florid osseous dysplasia,” which was published last year in Journal of Oral and Maxillofacial Pathology by a group at Mumbai’s Nair Hospital Dental College and retracted recently.

Here’s the notice, which is suggestive but doesn’t say much: Continue reading Dental papers retracted after investigations find “issue with respect to misconduct”

Another retraction for Pfizer’s experimental cancer treatment figitumumab

6794 BJC_newblue_V1.qxdLast month, we brought you news that Pfizer had retracted a paper in the Journal of Clinical Oncology

purporting to show a benefit of their experimental drug for lung cancer figitumumab after discovering that its clinical lead on the project had done analyses improperly.

There’s been another retraction, of a related paper, in the British Journal of Cancer, “Pre-treatment levels of circulating free IGF-1 identify NSCLC patients who derive clinical benefit from figitumumab.” Here’s the notice: Continue reading Another retraction for Pfizer’s experimental cancer treatment figitumumab

After retracted study’s cited, editors ask, “time to add scientific integrity to the downside of print on paper?”

JneuranesAs we — and others — have written, retracted articles don’t necessarily creep off to some little island somewhere never to be heard from again. After all, the electronic versions of about a third of retracted papers aren’t marked as retracted. Sometimes, like Napoleon, those papers return from exile to wreak havoc: They get cited as if they had never been retracted.

To wit: The Journal of Neurosurgical Anesthesiology has published a letter to the editor regarding a 2012 article by a group of Italian researchers. The topic of the paper in question was “Perioperative pregabalin for postoperative pain control and quality of life after major spinal surgery.”

That happens to have been an area of interest for one Scott Reuben, a Massachusetts anesthesiologist and pain specialist turned federal inmate who was, Continue reading After retracted study’s cited, editors ask, “time to add scientific integrity to the downside of print on paper?”

Two patch-clamping retractions in PNAS and the JCI after first author admits image manipulation

jci1212A group of cardiology researchers formerly of the University of Cologne has retracted two papers, after investigations into allegations of misconduct led to an admission of guilt by one of the lab’s junior members.

Here’s the first retraction, for “Connexin 43 acts as a cytoprotective mediator of signal transduction by stimulating mitochondrial KATP channels in mouse cardiomyocytes,” published last week in the Journal of Clinical Investigation: Continue reading Two patch-clamping retractions in PNAS and the JCI after first author admits image manipulation

Serial plagiarists earn lifetime publishing ban from Saudi journal

saudimedicineIn April, we wrote about a group of cancer researchers from Tunisia:

The M.O. of the group…appears to be quite simple: Find a study that looks easy to “replicate,” change a few of the particulars and submit as if it were a piece of local, original work.

One of the papers we cited in that post for appearing to be heavily plagiarized has now been retracted, with a heavy penalty for the authors. Here’s the notice, from the Annals of Saudi Medicine:  Continue reading Serial plagiarists earn lifetime publishing ban from Saudi journal

A new record: A retraction, 27 years later

jsbmbIn October, we noted the apparent record holder for longest time between publication and retraction: 25 years, for “Retention of the 4-pro-R hydrogen atom of mevalonate at C-2,2′ of bacterioruberin in Halobacterium halobium,” published in the Biochemical Journal in 1980 and retracted in 2005. (Although an author requested that another 52-year-old paper be retracted, it remains untouched in the literature.)

That record has now been broken. Congratulations to the Journal of Steroid Biochemistry and Molecular Biology and the authors of a December 1985 paper, “Increasing the response rate to cytotoxic chemotherapy by endocrine means.” Here’s the notice, which appears in the January 2013 issue of the journal, making 27 years — and a month, if you’re counting: Continue reading A new record: A retraction, 27 years later

“This publication should be ignored”: Authorship issues, flawed data fell neuro-oncology paper

Neon 2009 regular volume.inddThe Journal of Neuro-Oncology wants you to ignore the following paper: “A single chain (scFv425):sTRAIL fusion protein with specificity for the EGF receptor is effective in vitro but not in an in vivo brain tumor animal model.”

The 2007 article, from a group in The Netherlands, suffered from two fatal problems. According to the retraction notice: Continue reading “This publication should be ignored”: Authorship issues, flawed data fell neuro-oncology paper

Which came first? Plagiarism flap forces retraction of chicken nugget paper

food chem coverIt never pays to take a closer look at the inside of a chicken nugget.

The journal Food Chemistry has retracted a 2010 article by Iranian researchers who claimed to have used spectroscopy to examine the inner workings of breaded-fried chicken nuggets. Trouble was, someone else had already done the work.

Issues with the paper first surfaced in March, in the form of a correction that should have given the editors serious indigestion: Continue reading Which came first? Plagiarism flap forces retraction of chicken nugget paper