Category: immunology retractions

Authors retract PNAS paper suggesting silk stabilizes vaccines

PNASA PNAS paper that caught the media’s attention for suggesting that adding silk could stabilize vaccines and antibiotics has been pulled after the authors realized there were significant errors in the data analysis. 

According to the notice, the authors agreed to retract the 2012 paper; however, the corresponding author told us the authors did not think a retraction was required as, according to him, the conclusions remained valid.

The paper presented a solution to the long-standing problem that sensitive biological compounds such as vaccines and antibiotics begin to lose their effectiveness outside the recommended temperature range, and naturally biodegrade over time. The degradation process cannot be reversed, and may even speed up during transport or storage under less ideal temperatures.

Here’s the retraction notice: Continue reading Authors retract PNAS paper suggesting silk stabilizes vaccines

Fraudster loses third attempt to remove 7-year debarment

court caseA U.S. judge has denied a virology researcher’s third attempt to overturn a seven-year debarment from receiving federal funds, following a 2010 decision by the U.S. Office of Research Integrity.

The ORI banned Scott Brodie for seven years after concluding he had committed 15 acts of misconduct at the University of Washington. The deception affected grant applications, published papers, manuscripts, and presentations. Since then, Brodie has tried multiple times to reverse the ruling in court.

In the latest decision, dated June 13, United States District Judge James E. Boasberg writes: Continue reading Fraudster loses third attempt to remove 7-year debarment

Researcher who sued to stop retractions gets his sixth

Mario Saad
Mario Saad

A sixth retraction has appeared for a diabetes researcher who previously sued a publisher to try to stop his papers from being retracted.

Mario Saad‘s latest retraction, in PLOS Biology, stems from inadvertent duplications, according to the authors.  Though an investigation at Saad’s institution — the University of Campinas in Brazil — found no evidence of misconduct, a critic of the paper told The Scientist he does not believe that the issues with blots were inadvertent.

Previously, Saad sued the American Diabetes Association to remove four expressions of concern from his papers; they were later retracted, even though Unicamp recommended keeping three of them published.

Here’s the new retraction notice, for “Gut Microbiota Is a Key Modulator of Insulin Resistance in TLR 2 Knockout Mice:” Continue reading Researcher who sued to stop retractions gets his sixth

Software glitch — not intentional manipulation — sunk immunology paper, says author

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A black box appears over the control lane on the left

New evidence suggests a retracted paper was felled not by intentional manipulation — as it first appeared — but by a software glitch.

In 2014, we reported that Biochemical Journal had retracted a paper on suspicion it contained “shoddy Photoshopping”  — someone appeared to have blacked out a control lane in one figure. Now there’s evidence that it wasn’t done on purpose: An investigation at Duke into eight papers, including the Biochemical Journal paper, did not find evidence of misconduct; lead author Paul Kuo, currently chair of surgery at Loyola Medicine, told us that a glitch in the software caused the black box. Nevertheless, the journal does not plan to un-retract the paper. Continue reading Software glitch — not intentional manipulation — sunk immunology paper, says author

Antifungal drug paper didn’t have institution’s approval

Authors have pulled a paper on an antifungal drug that is potentially toxic because it lacked final approval from their institution.

The study describes a patient who had experienced liver toxicity after taking voriconazole. During the study, the authors re-administered the drug to the patient using “a slow dose titration.” But their institution didn’t approve the study before it was published online.

Here’s the retraction note for “Successful Rechallenge with Voriconazole following Medication-Induced Hepatotoxicity,” published in Antimicrobial Agents and Chemotherapy.  Continue reading Antifungal drug paper didn’t have institution’s approval

Journal temporarily removes paper linking HPV vaccine to behavioral issues

1-s2.0-S0264410X16X00084-cov150hThe editor in chief of Vaccine has removed a paper suggesting a human papillomavirus (HPV) vaccine can trigger behavioral changes in mice.

The note doesn’t provide any reason for the withdrawal, although authors were told the editor asked for further review.

Two co-authors on the paper — about Gardasil, a vaccine against HPV — have previously suggested that aluminum in vaccines is linked to autism, in research a World Health Organization advisory body concluded was “seriously flawed.”

Approximately 80 million doses of Gardasil were administered in the U.S. between 2006 and 2015. Both the the WHO and the Centers for Disease Control and Prevention have ruled the vaccine to be safe — the CDC, for instance, calls it “safe, effective, and recommended.”

The journal published an uncorrected proof of “Behavioral abnormalities in young female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil” online on January 9th, 2016. In its place now is a note that says:

Continue reading Journal temporarily removes paper linking HPV vaccine to behavioral issues

Paper on plant immunity can’t fight off manipulation

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A paper on how plants respond to bacteria has an invader of its own — data manipulation.

The “irregularities and inappropriate data manipulation” were found in a figure produced by the first author, Ching-Wei Chen, whose LinkedIn page lists him as a student at the National Taiwan University. The authors were unable to replicate the results in the figure, according to the note.

The authors are doing more experiments to verify the main conclusion of the 2014 paper, “The Arabidopsis Malectin-Like Leucine-Rich Repeat Receptor-Like Kinase IOS1 Associates with the Pattern Recognition Receptors FLS2 and EFR and Is Critical for Priming of Pattern-Triggered Immunity,” published in The Plant Cell.

The retraction note explains the what happened in more detail:

Continue reading Paper on plant immunity can’t fight off manipulation

Third retraction appears for Leiden researcher fired in 2013

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A researcher who was fired from Leiden University Medical Center in 2013 for fraud has notched a third retraction, following an investigation by her former workplace.

When Leiden fired Annemie Schuerwegh, they announced two retractions of papers that contained manipulated data. This third retraction — the last, according to a spokesperson for the center  — is for “a discrepancy between the data reported in the article and the original collected data,” per the note.

The 2011 paper, “Mast cells are the main interleukin 17-positive cells in anticitrullinated protein antibody-positive and -negative rheumatoid arthritis and osteoarthritis synovium” published in Arthritis Research & Therapy, suggests the source of a protein involved in rheumatoid arthritis. It has been cited 51 times, according to Thomson Scientific’s Web of Knowledge.

Here’s the retraction note:

Continue reading Third retraction appears for Leiden researcher fired in 2013

Science flags immune-boosting paper under investigation

F1.mediumScience magazine has issued an expression of concern for a paper on the discovery of a new immune-boosting protein. The paper’s findings, which received some press coverage when they came out last spring, are now under investigation by Imperial College London.

The expression of concern follows a correction noting a Western blot mix-up. Science Editor in Chief Marcia McNutt told us last month that the mistake resulted from “carelessness” on the part of the authors. But now, an investigation at Imperial College London — where Philip Ashton-Rickardt led the research — is formally looking into the findings.

That investigation is ongoing, according to the expression of concern (signed by McNutt):

Continue reading Science flags immune-boosting paper under investigation

Fifth retraction for Wayne State researcher who fudged figures

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Teresita L. Briones

Another retraction has appeared for Teresita Briones, who used to study neuroscience at Wayne State University — the final of five papers flagged by the Office of Research Integrity for containing falsified data.

According to the ORI notice published in May, Briones “intentionally, knowingly, and recklessly engaged in research misconduct by falsifying and/or fabricating data.” This latest paper to be retracted, which looks at the role of specific receptor in chronic inflammation of nervous tissue in rats, has two figures that “were duplicated, reused and falsely relabelled, and claimed to represent different experiments,” according to the retraction note.

The retraction note for “Chronic neuroinflammation and cognitive impairment following transient global cerebral ischemia: role of fractalkine/CX3CR1 signaling,” published in the Journal of Neuroinflammation, specifies the problematic figures:

Continue reading Fifth retraction for Wayne State researcher who fudged figures