What Caught Our Attention: Usually, an Expression of Concern (EOC) offers general language about “concerns regarding the validity of the data” or “concerns regarding the integrity of the study.” Here the language is anything but, saying that 54 Western blot bands within three figures have problems such as “visible pasted joints,” “square border,” and numerous “appear to be the same band.” According to the notice, the authors have not responded to requests for the original blots, so the editors are allowing the article to remain intact, choosing instead “to alert readers to these issues and allow them to arrive at their own conclusions regarding the figures.” Continue reading Caught Our Notice: 54 problems in three scientific images equals one expression of concern
Category: anesthesia retractions
Caught Our Notice: Big journal, big correction
Title: Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery
What Caught Our Attention: When the New England Journal of Medicine (NEJM) publishes a correction that is more than a misspelling of a name, we take a look. When NEJM publishes a 500-word correction to the data in a highly cited article, we take notice. This study tested the effects of a drug to prevent blood loss in patients undergoing heart surgery; it’s been the subject of correspondence between the authors and outside experts. The correction involved tweaks — lots of tweaks — to the text and tables, which did not change the outcomes. Continue reading Caught Our Notice: Big journal, big correction
Society recommends 9 retractions for co-author of researcher with record number of retractions
The Japanese Society of Anesthesiologists (JSA) has requested the retraction of nine additional papers by a co-author of fraudster Yoshitaka Fujii, after investigating allegations of fraud in dozens of papers.
According to the report, a committee investigated approximately 40 publications by Yuhji Saitoh of Yachiyo Medical Center and Tokyo Women’s Medical University and “identified ten publications with clear ethics violations, one of which has already been retracted.”
Saitoh has collaborated on many papers with Fujii, an anesthesia researcher with more than 180 retractions. As we reported, Saitoh resigned from the JSA when the investigation began, and the society permanently banned him. Continue reading Society recommends 9 retractions for co-author of researcher with record number of retractions
Lancet retracts (and replaces) paper a year after authors report error that changes “all numbers”
In March 2016, researchers in Switzerland and Canada published a meta-analysis in The Lancet, exploring the optimal painkiller and dose for treating pain in knee and hip osteoarthritis. Soon after, the authors were informed of an error that would change “all numbers” in a paper that may influence clinical practice.
The authors contacted The Lancet immediately, in July 2016, to inform them of the issue. Sven Trelle, the paper’s corresponding author, also told us: Continue reading Lancet retracts (and replaces) paper a year after authors report error that changes “all numbers”
Former prof fudged dozens of images, says university
On Dec. 2, 2013, Alison Lakin, the research integrity officer at the University of Colorado Denver, received a concerning email.
The emailer was alleging several problems in a 2012 paper in the Journal of Clinical Investigation, co-authored by one of its high-profile faculty members. Lakin discussed the allegations with some administrators and agreed they had merit; Lakin sequestered an author’s laptop and other materials. Over the next few months, the university learned of additional allegations affecting other papers — and discovered even more serious problems in the JCI paper. Namely, the first author had inserted changes to 21 figures in the paper after submitting it, without alerting the other authors, journal, or reviewers.
That journal retracted the paper this month, citing numerous problems:
Continue reading Former prof fudged dozens of images, says university
Anesthesiology society bans co-author of researcher with record-number of retractions
The Japanese Society of Anesthesiologists has permanently banned a co-author of notorious fraudster Yoshitaka Fujii, after investigating many of his publications for alleged fraud.
According to the announcement last month (in Japanese), a committee investigated approximately 40 publications by Yuhji Saitoh of Yachiyo Medical Center and Tokyo Women’s Medical University in Japan. Saitoh resigned from the society once the investigation started; after the committee found evidence of data manipulation and fraud, the society decided it would permanently ban him as a member.
Saitoh was a frequent co-author of Yoshitaka Fujii, an anesthesia researcher with a record-breaking number of retractions (more than 180). Last year, anesthesia fraud sleuth John Carlisle and a co-author analyzed Saitoh’s papers — including many he didn’t co-author with Fujii — and concluded there was very low likelihood the sampling had been conducted randomly, among other potential concerns.
On May 9, the Japanese Society of Anesthesiologists issued the following statement, which we translated:
Two in 100 clinical trials in eight major journals likely contain inaccurate data: Study
A sweeping analysis of more than 5,000 papers in eight leading medical journals has found compelling evidence of suspect data in roughly 2% of randomized controlled clinical trials in those journals.
Although the analysis, by John Carlisle, an anesthetist in the United Kingdom, could not determine whether the concerning data were tainted by misconduct or sloppiness, it suggests that editors of the journals have some investigating to do. Of the 98 studies identified by the method, only 16 have already been retracted. [See update at end.]
The types of studies analyzed — randomized controlled clinical trials — are considered the gold standard of medical evidence, and tend to be the basis for drug approvals and changes in clinical practice. Carlisle, according to an editorial by John Loadsman and Tim McCulloch accompanying the new study published today in Anesthesia, Continue reading Two in 100 clinical trials in eight major journals likely contain inaccurate data: Study
Researchers mistakenly administer three-fold higher dose of anesthesia
Researchers have retracted a 2016 paper after discovering that they accidentally administered three times the reported dose of anesthesia to rats.
In the Experimental Physiology paper, the authors set out to mathematically map how rats’ blood pressure changes under different conditions, which required the rats to be anesthetized. But their findings were called into question when they found the rats had received a much higher concentration of anesthesia than intended. According to the notice, this higher dose compromised the “objectives of the experiment.”
The corresponding author Karol Ondrias, from the Institute of Molecular Physiology and Genetics at the Slovak Academy of Sciences in Bratislava, told us how the dosing error occurred: Continue reading Researchers mistakenly administer three-fold higher dose of anesthesia
Editors retract paper about anesthesia procedure after investigation uncovers data issues
The editors of an anesthesiology journal have retracted a paper about predicting how patients will respond to a procedure, after the results of an investigation cast doubt on the validity and originality of the work.
According to the retraction notice, the editors became concerned about the validity of the data and conducted an investigation, which found irregularities, “including misrepresentation of results.” Because the authors could not provide adequate evidence to assuage these concerns, the editors decided to retract the paper.
The paper — about which facial muscles best predict if a patient is ready to be intubated — had already been flagged on F1000: A few years ago, two anesthesiologists from Florida commented that they found the article “confusing,” and felt that the authors “did not prove their hypothesis.”
Here’s the retraction notice for “Comparison of four facial muscles, orbicularis oculi, corrugator supercilii, masseter or mylohyoid, as best predictor of good conditions for intubation: A randomised blinded trial,” published in the European Journal of Anaesthesiology in 2013 and cited once: Continue reading Editors retract paper about anesthesia procedure after investigation uncovers data issues
When you have 94 retractions, what’s two more?
Attention Joachim Boldt: The 1990s are calling, and they want their papers back.
The Annals of Thoracic Surgery has retracted two papers from the early 1990s on which Boldt was the first author – bringing the retraction tally for the disgraced German anesthesiologist to 96, by our count. Both articles were found to contain manipulated data.
The first paper, from 1990, was titled “Acute Preoperative Plasmapheresis and Established Blood Conservation Techniques,” and was written when Boldt was on the faculty at Justus-Liebig University, in Giessen.
According to the notice:
Continue reading When you have 94 retractions, what’s two more?