Category: basic life sciences retractions

First author refuses to sign PNAS retraction after “key findings” are not reproduced

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Two out of the three authors of a PNAS paper on mutations underlying lung diseases are pulling it after failing to reproduce key findings.

The paper, published in 2012, investigated how mutations in lung surfactant genes induce molecular changes that lead to lung pulmonary fibrosis and lung cancer might work. But follow-up work revealed problems. In the retraction note, last author Christine Kim Garcia and second author Christoper Cano, both at the University of Texas Southwestern Medical Center, write:

Current members of the C.K.G. laboratory are unable to reproduce key findings reported in the paper.

Here’s the retraction note in full:

Continue reading First author refuses to sign PNAS retraction after “key findings” are not reproduced

Former UCSF grad student fudged data in two papers

ORIA former graduate student at the University of California, San Francisco “knowingly falsified and/or fabricated” data in two published papers, according to the Office of Research Integrity.

According to a case summary published this morning, Peter Littlefield was working on his PhD, studying the ways that cells respond to external signals, when he published the two problematic papers. He is the first author on the papers; Natalia Jura, whose lab he worked in, is the last on both.

The report’s findings are based on, among other sources, “the respondent’s admission.”

The first paper, “Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations” was published in Science Signaling and has been cited twice, according to Thomson Scientific’s Web of Knowledge.

Three figures in the paper are problematic, says the ORI summary:

Continue reading Former UCSF grad student fudged data in two papers

Investigation digs up data falsification in two papers on roundworm stress

18.coverAn investigation at the University of Florida has led to the retraction of a pair of papers on the stress responses of Caenorhabditis elegans in Molecular and Cellular Biology.

One paper has been retracted, and one “partially” retracted, as the main conclusion was “not compromised.” According to the retraction notes, the investigation found the data were “falsified” by first author Chi Leung, a former postdoc at UF.

Here’s the note in full for the partial retraction of “A Negative-Feedback Loop between the Detoxification/Antioxidant Response Factor SKN-1 and Its Repressor WDR-23 Matches Organism Needs with Environmental Conditions:”

Continue reading Investigation digs up data falsification in two papers on roundworm stress

A correction to a correction for stem cell researcher Jacob Hanna

Jacob Hanna
Jacob Hanna

A correction to a correction is the latest problem for highly cited researcher Jacob Hanna. The stem cell scientist — whose high-profile work has received scrutiny over the past year — has amended an earlier correction notice after a reader spotted an inadvertent “mistake.”

We reported on the original correction, to the 2009 Cell Stem Cell paper “Metastable Pluripotent States in NOD-Mouse-Derived ESCs,” in July. The paper has been cited 184 times, according to Thomson Scientific’s Web of Knowledge.

Apparently, a pair of images in the original correction note are of the same cell colonies, when they are supposed to be of separate cell colonies.

The new (and detailed) note explains how that happened:

Continue reading A correction to a correction for stem cell researcher Jacob Hanna

EMBO investigation yields two more retractions and three corrections for Voinnet

Olivier Voinnet
Olivier Voinnet

An investigation into the work of Olivier Voinnet by The EMBO Journal has led to another two retractions and three more corrections for the high-profile plant scientist, now suspended from the CNRS for two years.

According to the authors, Voinnet was responsible for some of the errors; all papers have been questioned on PubPeer.

The EMBO J, the flagship publication of the European Molecular Biology Organization, posted four notices earlier today and told Retraction Watch that the notice for the fifth paper would be posted by tomorrow.

This latest round brings our count for Voinnet up to Continue reading EMBO investigation yields two more retractions and three corrections for Voinnet

Trouble with data proves toxic for a pair of toxicology papers

logoA pair of papers about the risks of titanium dioxide nanoparticles that share many of the same authors has been retracted from a toxicology journal following an investigation at Soochow University in China.

Particle and Fibre Toxicology is retracting the papers for problems with the statistical methods and missing data, as well as for sharing figures.

Here’s the note for “Intragastric exposure to titanium dioxide nanoparticles induced nephrotoxicity in mice, assessed by physiological and gene expression modifications:”

Continue reading Trouble with data proves toxic for a pair of toxicology papers

Gold nanoparticle paper crushed by “deliberate and fraudulent use of data”

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Biotechnology Letters has retracted a paper on a new gene delivery technique due to “the deliberate and fraudulent use of data in the paper that had previously appeared in other papers of these two authors.”

The journal’s Editor in Chief Colin Ratledge told us that someone tipped him off that one of the authors, University of Kalyani microbiologist Keka Sarkar, had been self-plagiarizing:

I can say that a person who was familiar with the work of Dr Sarkar got in touch with about their concerns about her publications and, in particular, her paper published in Biotechnology Letters.  They supplied a dossier of her publications showing the obvious duplications of figures and that she had been using the same figures in different papers to illustrate the results from supposedly different experiments.

He found that, indeed, multiple figures in the Biotechnology Letters had appeared in other publications of Sarkar’s, some prior to the paper’s October 2013 publication, and one after. The details are in the whole retraction note:
Continue reading Gold nanoparticle paper crushed by “deliberate and fraudulent use of data”

Eighth retraction published for former physiology researcher

International Journal of CancerA lung cancer paper in the International Journal of Cancer has been retracted because of “serious errors related to image duplication.” This marks the eighth retraction for first author, ShouWei Han.

The decision was made by the journal’s editor-in-chief, the publisher Wiley and co-author Jesse Roman (a co-author on Han’s other retracted papers). According to the notice, Han didn’t respond “to requests by the journal or the co-author.”

In 2011, Han was the target of an investigation by his former employer, the University of Louisville in Kentucky. Papers in the Journal of Biological Chemistry, the American Journal of Respiratory Cell and Molecular Biology and American Journal of Physiology: Lung Cellular and Molecular Physiology have been retracted.

Here’s the full retraction notice for the latest retraction:

Continue reading Eighth retraction published for former physiology researcher

Authors withdraw immunology study, no reasons given

Journal of Biological Chemistry1Researchers have withdrawn a 2010 article in the Journal of Biological Chemistry about an immune regulator.

The paper was pulled without any explanation (in standard JBC style). Here’s the complete notice:

This article has been withdrawn by the authors.

The study’s authors were based out of Shandong University Medical School, Jinan General Hospital of Jinan Command and Duke University Medical Center.

Two of the authors have had previous papers retracted.

Continue reading Authors withdraw immunology study, no reasons given

The worm has turned: Nematode study retracted for misidentification

toxicol patholThe authors of a paper on parasitic nematodes have retracted the article because they misidentified the organism in question, so “the possibility of misleading readers was high.”

The paper, “Histopathological features of Capillaria hepatica infection in laboratory rabbits,” appeared in Toxicologic Pathology in 2009 and came from a lab at Huntingdon Life Sciences, in Cambridgeshire, England.

According to the abstract: Continue reading The worm has turned: Nematode study retracted for misidentification