Category: basic life sciences retractions

Mol bio paper pulled by PLOS following investigation into figures

Screen Shot 2015-11-17 at 11.58.47 AMPLOS Biology has retracted a paper about the molecular details of β-catenin expression following an investigation by the first author’s institution in Italy.

The investigation, by the Istituto Nazionale per la Ricerca sul Cancro, found that there were multiple “figure anomalies.” According to the note:

An explanation of inadvertent error was given for some of the issues identified, while for two issues, a satisfactory explanation could not be provided.

First author Roberto Gherzi says none of his co-authors helped prepare the figures. The authors maintain that the conclusions are unaffected, but that assurance wasn’t enough for the journal. Here’s more from the lengthy retraction note, which provides some backstory on the “serious concerns” regarding the data:

Continue reading Mol bio paper pulled by PLOS following investigation into figures

MD Anderson researcher Aggarwal up to six corrections

cover (2)A highly cited cancer researcher at MD Anderson has notched three major corrections, all associated with problems in figures. One note cites “human error” as the cause.

Bharat Aggarwal is the last author on all three papers. He is now up to six corrections, two unexplained withdrawals, and two Expressions of Concern. He’s also threatened to sue us in the past, and has told us that his institution has been looking into his work.

Only one note specifies that the correction does not affect the paper’s conclusions.

First up: “Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-κB signaling,” published in the International Journal of Cancer and cited 168 times, according to Thomson Scientific’s Web of Knowledge. The issues span two figures, according to the erratum note:

Continue reading MD Anderson researcher Aggarwal up to six corrections

“Carelessness” forces Science to correct paper about immune booster

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Science is fixing images in a paper published online in April that discovered an immune-boosting protein, after the authors mistakenly mixed up similar-looking Western blots.

The paper, which received some press coverage, identified a protein that helped the immune system fight off cancers and infections. Philip Ashton-Rickardt, a scientist at Imperial College London who led the study, told the The Telegraph:

This is exciting because we have found a completely different way to use the immune system to fight cancer.

The editor in chief of Science, Marcia McNutt, told us that the journal contacted the authors once it learned of “irregularities” in some of the figures, which did not affect the conclusions of the paper:

A bacterium may be anti-fungal, but it’s not anti-retraction

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The authors of a paper on an anti-fungal bacterium couldn’t ward off a very common problem: plagiarism. The people credited on the paper, published in Applied Microbiology and Biotechnology, apparently weren’t the original authors, according to the retraction note.

We’re not sure who the original authors are. The retraction note doesn’t elaborate much:

Continue reading A bacterium may be anti-fungal, but it’s not anti-retraction

Genetics paper retracted for using material “without permission and/or proper reference”

Molecular Genetics and GenomicsA review article about a tool used to link genes to traits and behaviors has been retracted for including content “without permission and/or proper reference.”

Corresponding author Ali Masoudi-Nejad at the University of Tehran told us that the retraction occurred mostly because the paper included many figures and tables from other sources, and he didn’t realize they needed to seek permission from both the author and the copyright-holder (ie, the publisher). He added that he doubts he is the only one to make this mistake: Continue reading Genetics paper retracted for using material “without permission and/or proper reference”

Intellectual property issues sink cancer paper in JACS

176 spine minimum. full size. Editor: Lingling JEM: Leslie RTP: Michael ReidThe authors of a paper on a mechanism for potential cancer therapies are retracting it after realizing they published some proprietary findings “without permission and agreement from St. Jude Children’s Research Hospital.”

According to the retraction note in Journal of the American Chemical Society, the authors included an X-ray crystal structure and data that were gathered at St. Jude’s and considered the hospital’s intellectual property. On the paper, the last author, Zhengding Su, listed an affiliation at St. Jude and Hubei University of Technology in China, along with Amersino Biodevelop Inc., based in Waterloo, Canada.

Here’s the note for “Efficient Reactivation of p53 in Cancer Cells by a Dual MdmX/Mdm2 Inhibitor:”  Continue reading Intellectual property issues sink cancer paper in JACS

“Most responsible course of action is to retract:” Duplicated images fell prostate cancer paper

International Journal of CancerA study on the cellular interactions underlying prostate cancer has been retracted after a whistleblower pointed out duplicated images in one of the paper’s figures that were “erroneously presented as unique.”

The International Journal of Cancer posted the notice in June. The authors backed the paper’s conclusions but agreed, “the most responsible course of action is to retract.”

The notice reads:

Continue reading “Most responsible course of action is to retract:” Duplicated images fell prostate cancer paper

Authors withdraw two papers from JBC — and that’s all we know

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Two sets of authors have withdrawn their papers from the Journal of Biological Chemistry. We’re telling you about the both together because, true to JBC form, there’s not too much to say.

The retraction notices for both papers — about the molecular underpinnings of cardiac fibroblasts and melanoma cells — are identical:

Continue reading Authors withdraw two papers from JBC — and that’s all we know

Mega-correction to several images in gastric cancer study

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A journal has issued a rather large correction — what we call “mega-correction” — to a 2014 paper on a gastric cancer biomarker that fixes problems with several of the study’s figures.

The authors write that despite the corrections, “the results and conclusions put forth in the article remain unchanged.”

The paper, “TMEFF2 Deregulation Contributes to Gastric Carcinogenesis and Indicates Poor Survival Outcome” explored the role of TMEFF2 in gastric cancer. The researchers found that the protein acts as a tumor suppressor, and low levels can indicate the presence of cancerous cells.

Here’s the full correction notice, published by Clinical Cancer Research in August:

Continue reading Mega-correction to several images in gastric cancer study

University revokes PhD of first author on retracted STAP stem cell papers

800px-Waseda_University_Logo.svgWaseda University has revoked the doctorate degree of the first author on the now-retracted Nature papers about a technique to create stem cells.

The technique — which claimed to provide a new way to nudge young cells from mice into pluripotency — was initially described in two 2014 Nature papers, both first-authored by Haruko Obokata. However, the papers were soon mired in controversy, corrected, then retracted later that year due to “several critical errors,” some of which were categorized by a RIKEN investigation as misconduct.

Shortly after Nature retracted the two papers, Waseda revoked Obokata’s doctorate degree — on a probationary basis, according to the university: Continue reading University revokes PhD of first author on retracted STAP stem cell papers