Something was fishy at China Normal University. According to the journal Anti-Cancer Drugs, a 2010 paper by researchers at the Beijing school — “3,30′-Diindolylmethane negatively regulates Cdc25A and induces a G2/M arrest by modulation of microRNA21 in human breast cancer cells” — turned out to have suffered from an unfortunate anomaly. According to the retraction notice: Continue reading We wrote what? Breast cancer paper falls to rogue author
Category: by reason for retraction
In retraction notice, Bulfone-Paus “declares” data and conclusions confirmed; journals accept six more retractions
There was more news today about papers co-authored by Silvia Bulfone-Paus, whose lab at Research Centre Borstel has been under investigation for scientific misconduct.
The EMBO Journal, which we reported last month had accepted the retraction of a 2005 Bulfone-Paus paper that has been cited 37 times, published the retraction notice for the study today:
Eight of the authors (ZO, LT, UM, PB, CB, DA, RP and SB-P) wish to retract this paper, following an independent formal investigation initiated by the Research Center Borstel into scientific misconduct (see http://www.fz-borstel.de/cms/index.php?id=1). The investigation concluded that multiple figures contained PCR and western blot duplications and possible other manipulations (Figures 2A, 3A, 4A, 5, 7A and 7C, Supplementary Figures S1A, S2A and S2B, unconfirmed: Figure 1C). The above signed declare that Vadim Budagian and Elena Bulanova conducted these experiments and generated the figures. The authors declare that key experiments presented in the majority of these figures were recently reproduced and that the results confirmed the experimental data and the conclusions drawn from them. However, due to these unacceptable irregularities, the listed authors retract this paper in its entirety and regret any adverse consequences that may have resulted from its publication. Vadim Budagian and Elena Bulanova declined to sign the retraction.
As retraction notices go, this is better than average, we must say. It’s certainly better than the many opaque notices we’ve seen. But there’s a line in there that Karin Wiebauer and David Hardman, both of whom brought the notice to our attention, found curious: Continue reading In retraction notice, Bulfone-Paus “declares” data and conclusions confirmed; journals accept six more retractions
No Potti retractions on the horizon from JAMA, NEJM
With the third retraction of a paper by Anil Potti this weekend, plus details of various investigations dribbling out, we decided to check in with the world’s two leading medical journals about whether they planned to retract the papers of Potti’s they’d published.
JAMA published two papers by Potti and colleagues: One, “Gene Expression Signatures, Clinicopathological Features, and Individualized Therapy in Breast Cancer,” appeared in 2008. It has been cited 51 times, according to Thomson Scientific’s Web of Knowledge, and was the subject of two letters. In one, a correspondent expressed concerns about the lack of information in the study about Continue reading No Potti retractions on the horizon from JAMA, NEJM
Lancet Oncology retracts previously questioned Anil Potti paper
Early in December, as the house of cards that is Anil Potti‘s publication record started to really collapse, we called attention to a paper in The Lancet Oncology that had already been the subject of a correction and Expression of Concern in July of last year. Today, the journal officially retracted the paper, “Validation of gene signatures that predict the response of breast cancer to neoadjuvant chemotherapy: a substudy of the EORTC 10994/BIG 00-01 clinical trial.” The paper was cited more than 100 times, according to Google Scholar.
The retraction notice: Continue reading Lancet Oncology retracts previously questioned Anil Potti paper
Georgia (well, the Medical College there, anyway) on our minds for a mysterious retraction
We’re watching a case which appears to involve more than meets the eye.
Molecular Endocrinology has retracted a 2010 study by researchers at the Medical College of Georgia. According to the Spartan retraction notice (we added a link): Continue reading Georgia (well, the Medical College there, anyway) on our minds for a mysterious retraction
And that’s 14: More (and more) Mori retractions, as Japanese cancer journal pulls three papers
The steady drip-drip-dripping sound you hear from the cancer literature these days comes from the stream of retractions involving studies by Naoki Mori, the now jobless scientist whose work on cancer viruses appears to be evaporating before our eyes.
Cancer Science, which used to be called the Japanese Journal of Cancer Research, has retracted three more of Mori’s papers, each of which, according to the journal, contained multiple unreliable images. That brings the tally of retractions involving Mori’s articles to 14 by our count, an impressive number by any measure. Mori has more than 50 papers to his name, however, so it’s possible that the number of retractions will grow.
Here are the latest retractions: Continue reading And that’s 14: More (and more) Mori retractions, as Japanese cancer journal pulls three papers
Inability to reproduce Dutch grad student’s data prompts two retractions from the cancer lit
We are watching an intriguing case out of the Netherlands, involving a young researcher whose dubious results have led to the retraction of a pair of papers.
The retracted articles, which appeared in 2008 in Cancer Research and the British Journal of Cancer, come from the lab of the prominent Dutch scientist Ed Roos, of the Netherlands Cancer Institute in Amsterdam. Both papers addressed the actions of certain chemokine receptors — molecules on cell surfaces that interact with blood proteins involved in the immune response — on the behavior of tumor cells.
The first author on each paper was Joost Meijer, at the time a graduate student in Roos’ shop.
The retraction notices contain essentially the same information, although in the case of the BJC article — “Effect of the chemokine receptor CXCR7 on proliferation of carcinoma cells in vitro and in vivo” — the letter is quite personal. Dated Jan. 4, 2011, it reads: Continue reading Inability to reproduce Dutch grad student’s data prompts two retractions from the cancer lit
Clinical Infectious Diseases retracts antibiotic guidelines after posting uncorrected version
A few days after Clinical Infectious Diseases published a set of guidelines for using antibiotics in patients with cancer and dangerously compromised immune systems, we noticed that they had retracted the paper. The Medline notice read: Continue reading Clinical Infectious Diseases retracts antibiotic guidelines after posting uncorrected version
Sixth Bulfone-Paus retraction accepted
A journal has accepted the sixth retraction of a paper co-authored by Silvia Bulfone-Paus, the Research Centre Borstel announced late last week. Borstel has been investigating allegations that two of Bulfone-Paus’s former postdocs manipulated images.
The paper, in the Scandinavian Journal of Immunology, is titled Continue reading Sixth Bulfone-Paus retraction accepted
Cracking the Mori case: A reviewer describes how manipulated images came to light
We’ve had two questions since learning of the fraud case involving Naoki Mori: Who discovered the manipulations? And how?
We now have answers. We recently received an e-mail from a researcher who specializes in Mori’s field — cancer viruses — and who claims to have been a reviewer of a paper he submitted early last year to a journal in his field. (We’re obscuring some details to maintain our source’s anonymity.)
During what turned out to be a “painful” review of the manuscript: Continue reading Cracking the Mori case: A reviewer describes how manipulated images came to light