Paper on GI cancers linked to AIDS pulled for errors that upped tumor incidence

gastroGastroenterology has retracted a 2012 article on GI cancers associated with AIDS after the authors, from the National Cancer Institute, acknowledged that a “programming” error led them to overestimate the incidence of the tumors.

The paper, “Increased Risk of Stomach and Esophageal Malignancies in People With AIDS,” received a significant amount of attention when it first appeared, including a press release from the American Gastroenterological Association and several news articles. Here are its primary findings, according to the abstractContinue reading Paper on GI cancers linked to AIDS pulled for errors that upped tumor incidence

Scientists call for retraction of “seriously misleading” paper with asbestos industry ties

EBPHEleven scientists are asking a journal to consider retracting an asbestos paper with industry ties for including “seriously misleading information,” “several wrong statements,” and thrice citing a journal that doesn’t appear to exist.

Editors of the journal, Epidemiology Biostatistics and Public Health, however, say they will not retract the article, based on the advice of two external reviewers.

An earlier correction for the paper,  “Further Studies of Bolivian Crocidolite – Part IV: Fibre Width, Fibre Drift and their relation to Mesothelioma Induction: Preliminary Findings,” cited previously undisclosed competing interests for four of the paper’s five authors.

Earlier this year, scientists criticized “gross mistakes” in another paper from three of the same authors: Edward Ilgren, Yumi Kamiya, and John Hoskins. EBPH subsequently issued two corrections but did not retract that paper. Read our full coverage here. Continue reading Scientists call for retraction of “seriously misleading” paper with asbestos industry ties

Neuroscience journal retracts paper for lack of “scientific soundness”

Screen Shot 2016-03-03 at 9.21.12 AMAn unusual article that considered the concept of change from a systems perspective — including change in medicine, economics, and decision-making, for instance — has, well, changed from “published” to “retracted.”

After commenters on PubPeer called the 2014 paper “gibberish” and even suggested it might be computer-generated, Frontiers in Computational Neuroscience retracted it, noting it “does not meet the standards of editorial and scientific soundness” for the journal, according to the retraction notice. The paper’s editor and author maintain there was nothing wrong with the science in the paper.

Here’s the full note for “Sensing risk, fearing uncertainty: systems science approach to change:” Continue reading Neuroscience journal retracts paper for lack of “scientific soundness”

Family squabble over safety of eye therapy forces journal to pull paper

Screen Shot 2016-03-11 at 5.41.35 PM

A father and son are fighting over whether a laser therapy they describe as co-authors of a 2015 paper could be harmful to patients, prompting the journal to retract the article.

The small study suggested that the therapy could safely treat patients with glaucoma. But Tomislav Ivandic — the father — alleges that errors in how the study was reported could lead to harmful doses of laser light for patients receiving the therapy. His son and co-author, Boris Ivandic, maintains that the article is accurate.

To err on the side of patient safety, Photomedicine and Laser Surgery retracted “Effects of Photobiomodulation Therapy on Patients with Primary Open Angle Glaucoma: A Pilot Study.”

The retraction note explains the dispute:

Continue reading Family squabble over safety of eye therapy forces journal to pull paper

Poll: If authors don’t address mistakes, is that misconduct?

cover_natureIn an interesting letter printed in today’s Nature, biologists Sophien Kamoun and Cyril Zipfel suggest that “failure by authors to correct their mistakes should be classified as scientific misconduct.”

They note that this policy is already in place at their institute, The Sainsbury Laboratory (TSL).

We contacted Kamoun to ask what constituted a mistake, given that numerous papers have received queries, such as on sites like PubPeer, but it’s not clear whether those are legitimate mistakes. He told us: Continue reading Poll: If authors don’t address mistakes, is that misconduct?

We’re using a common statistical test all wrong. Statisticians want to fix that.

ASA-newlogoAfter reading too many papers that either are not reproducible or contain statistical errors (or both), the American Statistical Association (ASA) has been roused to action. Today the group released six principles for the use and interpretation of p values. P-values are used to search for differences between groups or treatments, to evaluate relationships between variables of interest, and for many other purposes.  But the ASA says they are widely misused. Here are the six principles from the ASA statement:  Continue reading We’re using a common statistical test all wrong. Statisticians want to fix that.

Molecular self-assembly paper fell apart

1049_soft_matter_f2c-900Authors are retracting a 2014 paper about how liquid-crystalline materials self-organize in low temperature conditions after realizing they had measured the temperatures incorrectly.

The error affected three figures and a table in “Milestone in the NTB phase investigation and beyond: direct insight into molecular self-assembly.” The paper, published in Soft Matter, has been cited three times, according to Thomson Reuters Web of Science.

The retraction note, published in August, offers more detail as to exactly what went wrong:

Continue reading Molecular self-assembly paper fell apart

Top journals give mixed response to learning published trials didn’t proceed as planned

Ben Goldacre
Ben Goldacre

Ben Goldacre has been a busy man. In the last six weeks, the author and medical doctor’s Compare Project has evaluated 67 clinical trials published in the top five medical journals, looking for any “switched outcomes,” meaning the authors didn’t report something they said they would, or included additional outcomes in the published paper, with no explanation for the change. The vast majority – 58 – included such discrepancies. Goldacre talked to us about how journals – New England Journal of Medicine (NEJM), JAMA, The Lancet, BMJ, and Annals of Internal Medicine — have responded to this feedback.

Retraction Watch: When you discover a published trial has switched outcomes, what do you do? Continue reading Top journals give mixed response to learning published trials didn’t proceed as planned

CDC fixes major error in flooring risk report: Not converting to metric

CDCThe U.S. Centers for Disease Control and Prevention issued a correction notice to a report about formaldehyde in laminate flooring, saying a mistake had caused them to significantly underestimate the health risks.

The mistake: According to CBS’s 60 Minutes, the CDC sometimes didn’t convert feet to meters. Ouch.

In the corrected report, the agency estimates the health risks of the laminate flooring — by irritating the ear, nose and throat — to be three-fold higher than what they suggested in the original report, published February 10.

Here’s the note that now appears in the link to the original CDC report: Continue reading CDC fixes major error in flooring risk report: Not converting to metric

Why publishing negative findings is hard

Jean-Luc Margot
Jean-Luc Margot

When a researcher encountered two papers that suggested moonlight has biological effects — on both plants and humans — he took a second look at the data, and came to different conclusions. That was the easy part — getting the word out about his negative findings, however, was much more difficult.

When Jean-Luc Margot, a professor in the departments of Earth, Planetary & Space Sciences and Physics & Astronomy at the University of California, Los Angeles, tried to submit his reanalysis to the journals that published the original papers, both rejected it; after multiple attempts, his work ended up in different publications.

Disagreements are common but crucial in science; like they say, friction makes fire. Journals are inherently disinterested in negative findings — but should it take more than a year, in one instance, to publish an alternative interpretation to somewhat speculative findings that, at first glance, seem difficult to believe? Especially when they contain such obvious methodological issues such as presenting only a handful of data points linking biological activity to the full moon, or ignore significant confounders?

Margot did not expect to have such a difficult experience with the journals — including Biology Letters, which published the study suggesting that a plant relied on the full moon to survive: Continue reading Why publishing negative findings is hard